Physiopathology, Diagnosis, and Treatment of GH Deficiency

  • Fatih Tanriverdi
  • Fahrettin Kelestimur
Reference work entry
Part of the Endocrinology book series (ENDOCR)


Growth hormone deficiency (GHD) in adults arises due to decreased secretion of GH from the pituitary gland. Until two decades ago, GHD in adults was not accepted as a clinical syndrome, and it was supposed that GH has little physiologic effects after adolescence. However after the advent of recombinant GH, physiologic role of GH becomes clearer in the adult life, and the studies during the last two decades revealed GHD as a real disease associated with a plenty of clinical manifestations. GHD is one of the most common hormonal deficiencies in adults with hypopituitarism due to variety of causes. In the present chapter, acquired causes, pathophysiology, diagnosis, and treatment of GHD in adults will be discussed based on the recent advances in the literature.


Growth hormone deficiency (GHD) Growth hormone replacement therapy (GHRT) Hypopituitarism Recombinant GH (rhGH) Traumatic brain injury (TBI) Sheehan’s syndrome Pituitary Hypothalamus 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Endocrinology and MetabolismErciyes University Medical SchoolKayseriTurkey

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