Neuroendocrinology of Bone Metabolism

  • Gherardo Mazziotti
  • Mauro Doga
  • Annamaria Formenti
  • Stefano Frara
  • Filippo Maffezzoni
  • Andrea Giustina
Reference work entry
Part of the Endocrinology book series (ENDOCR)


Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. As a matter of fact, skeletal fragility associated with high risk of fractures is a common complication of pituitary diseases characterized by either hypo- or hyperfunction of the pituitary gland. This chapter deals with physiological, pathophysiological, clinical, and therapeutic aspects concerning the effects of pituitary hormones on skeletal health.


Pituitary diseases Osteoporosis Bone mineral density Fractures Growth hormone Prolactin Cortisol Sex steroids 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Gherardo Mazziotti
    • 2
  • Mauro Doga
    • 1
  • Annamaria Formenti
    • 3
  • Stefano Frara
    • 1
  • Filippo Maffezzoni
    • 3
  • Andrea Giustina
    • 1
  1. 1.San Raffaele Vita-Salute UniversityMilanItaly
  2. 2.Endocrine Unit, Department of MedicineA.S.S.T. Carlo PomaMantovaItaly
  3. 3.Department of Molecular and Translational MedicineUniversity of BresciaBresciaItaly

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