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Urethral Carcinoma

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Urologic Oncology
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Abstract

Urethral carcinoma is a rare urogenital malignancy. Therefore, there are currently critical gaps in the understanding of the biology of the disease. Urethral carcinoma is diagnosed either as a primary tumor detected primarily in the urethra (PUC) or secondary one as a recurrence in the urethra after treatment of a urothelial carcinoma elsewhere in the urinary tract. Both primary and secondary urethral carcinomas are predominantly of urothelial histology. Most patients present with symptoms associated with locally advanced disease. Lymph node status is a strong predictor for outcomes in nonmetastatic PUC. In men, risk factors for the development of a SUC after radical cystectomy (RC) include non-muscle-invasive tumor stage at RC, tumor multifocality, non-orthotopic urinary diversion, superficial and invasive prostatic tumor involvement, and a positive urethral margin at RC. In women, risk factors for secondary urethral carcinoma after RC include multifocal or recurrent bladder cancer, bladder neck involvement, and a positive urethral margin at RC. In the absence of metastatic disease, urethral-sparing surgery can be utilized in distal tumors as an alternative to radical surgery provided negative surgical margins can be achieved intraoperatively. Treatment of proximal or advanced tumors most often consists of radical surgery with perioperative chemo- or chemoradiotherapy.

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Correspondence to Georgios Gakis .

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Gakis, G. (2019). Urethral Carcinoma. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42623-5_40

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  • DOI: https://doi.org/10.1007/978-3-319-42623-5_40

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42622-8

  • Online ISBN: 978-3-319-42623-5

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