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Urologic Oncology pp 1–9Cite as

Metastatic Bladder Cancer Disease and Its Treatment

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Abstract

Approximately one third of patients present with muscle-invasive bladder cancer with 50% developing progression after radical cystectomy and up to 15% having metastatic disease upfront. Several independent clinical prognostic factors for first- and for second-line chemotherapy have been identified to predict survival. Since 1980 standard first-line treatment contains a platinum-based combination chemotherapy. In the second-line setting, no clearly established regimen with substantial prolonged survival existed for a long period of time. Quite recently, based on compelling phase II and phase III data with simultaneously favorable safety profiles, several checkpoint inhibitors (PD-1/ PD-L1) have been FDA and EMA approved not only for patients progressing after first-line chemotherapy but also for upfront therapy in platinum-unfit patients.

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Conflicts of Interest

Anja Lorch: advisory role: BMS, Novartis, Ipsen, AstraZeneca

Günter Niegisch: travel expenses: Roche Pharma AG, Pfizer Pharma AG; advisory role: Roche Pharma AG, BMS Health; reserach grant: 4SC AG

Author information

Authors and Affiliations

  1. Department of Urology, Genitourinary Medical Oncology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

    Anja Lorch

  2. Department of Urology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

    Günter Niegisch

Authors
  1. Anja Lorch
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  2. Günter Niegisch
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Corresponding author

Correspondence to Anja Lorch .

Editor information

Editors and Affiliations

  1. Dept. of Urology & Urologic Oncology, Hannover Medical School, Hannover, Germany

    Axel S. Merseburger

  2. Dept. of Urology, University of Regensburg St. Josef Medical Centre, Regensburg, Germany

    Maximilian Burger

Section Editor information

  1. der Universität Regensburg, Oberarzt der Klinik für Urologie, Regensburg, Germany

    Wolfgang Otto

  2. Departement of Urology, Weill Cornell Medical Center, New York, NY, USA

    Shahrokh F. Shariat

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Lorch, A., Niegisch, G. (2018). Metastatic Bladder Cancer Disease and Its Treatment. In: Merseburger, A., Burger, M. (eds) Urologic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-42603-7_26-1

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  • DOI: https://doi.org/10.1007/978-3-319-42603-7_26-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42603-7

  • Online ISBN: 978-3-319-42603-7

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