Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Basal Cell Carcinoma of the Anal Margin

  • Denis ChatelainEmail author
  • Jean-François Fléjou
Reference work entry


Basal cell carcinoma of the anal margin is a malignant epithelial neoplasm. It consists of basaloid cells, and on microscopic examination, it is similar to conventional basal cell carcinoma of the skin (Gibson and Ahmed 2001).

The etiology of this tumor is unknown, but there is neither an evidence for a role of infection by HPV nor a role of ultraviolet radiation, unlike other basal cell carcinoma occurring in the sun-exposed skin. Some patients have a history of radiotherapy in the pelvic area. For some authors, the occurrence of this tumor could be favored by chronic skin irritation or a local trauma.

Clinical Features

Patients present with a perianal ulcerated tumor and complain of itching or local irritation. Some physicians sometimes initially misdiagnose these cancers as inflammatory or infectious skin lesions. Some patients have multiple basal cell carcinomas at other anatomic sites and the diagnosis of basal cell carcinoma of the anal margin should prompt an...
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References and Further Reading

  1. Gibson, G. E., & Ahmed, I. (2001). Perianal and genital basal cell carcinoma: A clinicopathologic review of 51 cases. Journal of the American Academy of Dermatology, 45, 68–71.CrossRefGoogle Scholar
  2. Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology & Laboratory Medicine, 134, 1601–1611.Google Scholar

Copyright information

© Springer International Publishing 2017

Authors and Affiliations

  1. 1.Service d’Anatomie PathologiqueCentre Hospitalier et Universitaire du NordAmiensFrance
  2. 2.Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie PathologiquesHôpital Saint-AntoineParisFrance