Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Verrucous Carcinoma/Giant Condyloma of Buschke and Löwenstein

  • Denis ChatelainEmail author
  • Jean-François Fléjou
Reference work entry


Verrucous carcinoma and giant condyloma of Buschke and Löwenstein are identical lesions.


Verrucous carcinoma is nowadays assimilated by most authors as giant condyloma described by Buschke and Löwenstein. It is a particular variant of anal and perianal squamous cell carcinoma, characterized by its slow growing, and its tendency to form abscesses and fistulae. It is associated with HPV6 and HPV11 infections.

Clinical Features

Patients usually present with a huge perianal oozing mass. The lesion has usually been present for many years and had a slow growth. Patients may also complain of anal pain, bleeding, pruritus, difficulty in walking and defecation, fistula, or perianal abscess.
  • Incidence

    Anal verrucous carcinoma is a very rare tumor and it is difficult to assess its incidence.

  • Age

    The mean age at presentation is 42 years (16–82 years).

  • Sex

    The incidence in males is significantly higher than in females (ratio 3.2:1).

  • Site

    Verrucous carcinoma often occurs in the...

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References and Further Reading

  1. Longacre, T. A., Kong, C. S., & Welton, M. L. (2008). Diagnostic problems in anal pathology. Advances in Anatomic Pathology, 15, 263–278.CrossRefGoogle Scholar
  2. Safi, F., Bekdache, O., Al-Salam, S., Alashari, M., Mazen, T., & El-Salhat, H. (2013). Management of peri-anal giant condylomaacuminatum – A case report and literature review. Asian Journal of Surgery, 36, 43–52.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Service d’Anatomie PathologiqueCentre Hospitalier et Universitaire du NordAmiensFrance
  2. 2.Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie PathologiquesHôpital Saint-AntoineParisFrance