Esophageal Squamous Columnar Junction
Esophageal squamous-columnar junction
The Z-line or squamous-columnar junction (SCJ) is the point of the esophagus where the stratified squamous esophageal lining meets the columnar epithelium (Spechler 2004). The esophagus is normally lined by a stratified squamous epithelium, whereas the gastric body and fundus exhibit a columnar lining with abundant mucous cells at the foveolar surface and numerous parietal and chief cells at the deep glands. These two types of epithelia normally meet together in an abrupt transition that is endoscopically and histologically recognized. Though the Z-line or SCJ is a very well-defined anatomical structure, its precise anatomical location and histological features are still disputed.
The Z-line is located at the body of the esophagus.