Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Gastric Xanthelasma

  • Xiaogang WenEmail author
Reference work entry


Gastric xanthoma


Gastric xanthelasma is a sharply demarcated yellowish accumulation of lipid-containing macrophages (xanthomatous cells) within the gastric mucosa. They may develop in the setting of cholestasis and hypercholesterolemia.

Clinical Features

  • Prevalence

    The reported prevalence of upper gastrointestinal xanthelasma is 0.23%. Approximately 76% of the lesions are located in the stomach, particularly in the antrum and the pyloric region (70%).

  • Age

    The incidence increases with age, reaching the highest values between 40 and 60 years of age.

  • Sex

    Xanthelasma seems to be more frequent in women, though there are some discrepancies in the literatures regarding gender predilection.

  • Site

    Most lesions localize in the antrum and the pylorus.

  • Treatment

    The lesion itself does not cause symptoms and does not need treatment. However, it is often associated with duodenal reflux, chronic gastritis, gastric surgery, or even cancer. The treatment of the primary...

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References and Further Reading

  1. Gürsoy, S., Yurci, A., Torun, E., Soyuer, I., Güven, K., Ozbakir, O., & Yücesoy, M. (2005). An uncommon lesion: gastric xanthelasma. The Turkish Journal of Gastroenterology, 16(3), 167–170.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Centro hospitalar de Vila Nova de Gaia/EspinhoInstitute of Molecular Pathology and Immunology of the University of PortoPortoPortugal