Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Tubular Adenocarcinoma

  • Chella R. S. van der PostEmail author
  • Fátima Carneiro
Reference work entry


Intestinal-type adenocarcinoma


Tubular adenocarcinoma is one of the five main types of gastric adenocarcinoma in the WHO classification scheme and represents the most common type of gastric adenocarcinoma. Together with papillary carcinoma and (part of) mucinous carcinoma, tubular carcinoma represents intestinal-type adenocarcinoma in the Laurén classification. Tubular adenocarcinomas are made up of simple or branching tubules resembling colorectal carcinoma and less commonly small, acinar structures sometimes resembling antral glands.

Gastric cancer has a complex pathogenesis, in which several factors are involved including a familial risk and environmental factors, with the strongest known risk factor being chronic gastritis induced by H. pylori infection. In 1994, the WHO classified H. pylorias a class I carcinogen based mainly on epidemiological evidence for its role in the pathogenesis of gastric adenocarcinoma. Several bacterial virulence factors define the...

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References and Further Reading

  1. Allum, W. H., Blazeby, J. M., Griffin, S. M., Cunningham, D., Jankowski, J. A., & Wong, R. (2011). Guidelines for the management of oesophageal and gastric cancer. Gut, 60(11), 1449–1472.CrossRefGoogle Scholar
  2. Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2010). WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.Google Scholar
  3. Cancer Genome Atlas Research, N. (2014). Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 513(7517), 202–209.Google Scholar
  4. Ferlay, J., Soerjomataram, I., Ervik, M., et al. (2013). GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide. IARC CancerBase 11. International Agency for Research on Cancer (
  5. Price, T. J., Shapiro, J. D., Segelov, E., Karapetis, C. S., Pavlakis, N., Van Cutsem, E., et al. (2012). Management of advanced gastric cancer. Expert Review of Gastroenterology & Hepatology, 6(2), 199–208. quiz 209.CrossRefGoogle Scholar
  6. Wong, H., & Yau, T. (2013). Molecular targeted therapies in advanced gastric cancer: Does tumor histology matter? Therapeutic Advances in Gastroenterology, 6(1), 15–31.CrossRefGoogle Scholar
  7. Zang, Z. J., Cutcutache, I., Poon, S. L., Zhang, S. L., McPherson, J. R., Tao, J., et al. (2012). Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature Genetics, 44(5), 570–574.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
    Email author
  • Fátima Carneiro
    • 2
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Faculty of Medicine of Porto UniversityCentro Hospitalar São João and Ipatimup/i3SPortoPortugal