Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Squamous Papilloma, Upper Gastrointestinal Tract

  • Rita Canas MarquesEmail author
  • Paula Chaves
Reference work entry


Benign papillomata; Malpighian papilloma


The upper gastrointestinal tract squamous papilloma described in this section will address exclusively the esophageal squamous papilloma. Anatomically, one could argue if pharyngeal squamous papilloma could also be included in this section, but it will be discussed in the squamous papilloma of the upper respiratory tractsection.

Esophageal squamous papilloma is a benign polypoid lesion that usually presents with a wart-like configuration at upper endoscopy. In general, the microscopic appearance of esophageal squamous papilloma is composed of a stromal core of lamina propria lined by mature stratified squamous epithelium.

Clinical Features

  • Incidence

    Esophageal squamous papilloma is an uncommon lesion with less than 200 cases described in the worldwide literature.

    The estimated incidence varies between 0.01% and 0.45%, in endoscopic series, while studies based on autopsies series reveal a prevalence of 0.006–0.04% of the...

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References and Further Reading

  1. Attila, T., et al. (2009). Esophageal papillomatosis complicated by squamous cell carcinoma. Canadian Journal of Gastroenterology, 23, 415–419.CrossRefGoogle Scholar
  2. Bohn, O. L., et al. (2008). Identification of human papillomavirus in esophageal squamous papillomas. World Journal of Gastroenterology, 14, 7107–7111.CrossRefGoogle Scholar
  3. Brandt, L. J. (2011). Esophageal squamous papilloma. Gastrointestinal Endoscopy, 73, 1035.CrossRefGoogle Scholar
  4. Gomez, N. A., et al. (1997). Esophageal squamous papilloma: A case report and a review of the literature. Acta Gastroenterologica Latinoamericana, 27, 131–133.PubMedGoogle Scholar
  5. Kanth, P., & Go, F. (2011). Squamous papilloma: An unusual esophageal entity. Endoscopy, 53, E405–E406.CrossRefGoogle Scholar
  6. Lewin, K. J., & Appelman, H. D. (1995). Tumors of theesophagus & stomach: Atlas of tumor pathology. In American registry of pathology (pp. 31–32). Washington, DC: Armed Forced Institute of Pathology.Google Scholar
  7. Mosca, S., et al. (2001). Squamous papilloma of the esophagus: Long-term follow up. Journal of Gastroenterology and Hepatology, 16, 857–861.CrossRefGoogle Scholar
  8. Odze, R., & Goldblum, J. (2009). Surgical pathology of the GU tract, liver, billiary tract and pancreas (pp. 406–407). Philadelphia: Saunders Elsevier.Google Scholar
  9. Odze, R., et al. (1993). Esophageal squamous papillomas: A clinicopathological study of 38 lesions and analysis for human papillomavirus by the polymerase chain reaction. American Journal of Surgical Pathology, 17, 803–812.CrossRefGoogle Scholar
  10. Rebeuh, J., et al. (2011). Esophageal squamous papilloma in children. Endoscopy, 43, E256.CrossRefGoogle Scholar
  11. Tabatabaei, S. A., et al. (2009). Giant esophageal squamous papilloma: A case report. Journal of Digestive Diseases, 10, 228–230.CrossRefGoogle Scholar
  12. Takeshita, K., et al. (2006). Clinicopathological characteristics of esophageal squamous papillomas in japonese patients – With comparison of findings from western countries. Acta Hitochemistry Cytochemistry, 39, 23–30.CrossRefGoogle Scholar
  13. Waterfall, W. E., et al. (1978). Benign oesophagealpapillomatosis. A case report with a review of the literature. Journal of Clinical Pathology, 31, 111–115.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil and Faculdade de Ciências MédicasUniversidade Nova de LisboaLisbonPortugal
  2. 2.Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco GentilLisbonPortugal
  3. 3.Faculdade de Ciências da Saúde, Universidade da Beira InteriorCovilhãPortugal