Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Sarcoidosis, Gastrointestinal

  • Susana RodriguesEmail author
Reference work entry


Abdominal sarcoidosis; Gastrointestinal manifestations of sarcoidosis; Granulomatous gastroenteritis


Sarcoidosis is a noncaseating granulomatous disease, likely of autoimmune etiology, that causes inflammation and tissue damage in multiple organs, most commonly the lung, but also skin, and lymph nodes, characterized by the formation of noncaseating granulomas. The infiltration of CD4 + −activated T-cells represents the immunological hallmark of sarcoidosis. If persistent, this inflammatory process is followed by the formation of granulomas. The accumulated inflammatory cells and granulomas result in distortion of the architecture of the affected tissue and, ultimately, organ dysfunction. Constitutional symptoms include weight loss, myalgias, night sweats, and fever and are most frequent early in the disease. A common acute presentation is erythema nodosum with arthralgias and hilar adenopathy (Lofgren’s syndrome). Over 90% of patients have lung involvement. The...

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References and Further Reading

  1. 1.
    Akdogan, M., Ulas, M., Kayhan, B., Orug, T., & Aydog, G. (2008). Gastrointestinal sarcoidosis mimicking colonic cancer. Turkish Journal of Gastroenterology, 19(2), 136–138.PubMedGoogle Scholar
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    Kchaou Ouakaa, A., Kochlef, A., Kilani, A., Kharrat, J., Romani, M., Gargouri, D., Belhadj, N., Ghorbel, A., Khayat, O., & Ben Ayed, M. (2003). Gastric and colonic sarcoidosis. A case report. La Tunisie Médicale, 81(11), 902–906.PubMedGoogle Scholar
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    Maàmouri, N., Guellouz, S., Ben Hariz, F., Ketari, S., Belkahla, N., Ouerghi, H., Chelly-Enneifer, I., Chouaib, S., Moncef Zitouna, M., & Ben Mami, N. (2010). Gastrointestinal sarcoidosis. La Revue de Médecine Interne, 31(4), 262–267.CrossRefGoogle Scholar
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    Vahid, B., Spodik, M., Braun, K. N., Ghazi, L. J., & Esmaili, A. (2007). Sarcoidosis of gastrointestinal tract: a rare disease. Digestive Diseases and Sciences, 52(12), 3316–3320.CrossRefGoogle Scholar
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    Ushiki, A., Koizumi, T., Kubo, K., Suzawa, K., Arakura, N., & Suzawa, H. (2009). Colonic sarcoidosis presenting multiple submucosal tumor-like lesions. Internal Medicine, 48(20), 1813–1816.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Serviço de Gastrenterologia, Centro Hospitalar de São JoãoAlameda Professor Hernani MonteiroPortoPortugal