Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Pseudoepitheliomatous Hyperplasia, Esophageal

  • Ricardo FonsecaEmail author
  • Paula Chaves
Reference work entry


Atypical regenerative hyperplasia; Reactive hyperplasia


Pseudoepitheliomatous hyperplasia (PEH) is a morphologic pattern of reactive squamous epithelial proliferation that occurs in response to underlying infections, inflammations, or neoplasms (Kune 2012; Noffsinger 2007). It is characterized by parallel, elongated, and occasionally irregular columns of highly reactive squamous cells, with prominent nucleoli and abundant mitoses that may extend deep into the lamina propria. Its appearance may simulate invasive squamous cell carcinoma. On occasion, this reaction may be endoscopically visible, and this may cause diagnostic confusion with a malignant lesion (Odze 2009).

Clinical Features

As PEH is a reactive epithelial proliferation, and so its clinical features (incidence, age, sex, site, or macroscopic features) are mostly dependent on the underlying infectious, inflammatory, or neoplastic conditions.
  • Treatment

    No specific treatment for this condition is required,...

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References and Further Reading

  1. Bouquot, J. E. (2001). Diagnostic surgical pathology of the head and neck (pp. 205–207). Philadelphia: WB Saunders.Google Scholar
  2. Kune, Y. T. (2012). The Korean Journal of Pathology, 46(4), 331–340.CrossRefGoogle Scholar
  3. Lamps, L. (2010). Diagnostic pathology: Gastrointestinal. Salt Lake City, UT: Amirsys.Google Scholar
  4. Noffsinger, A. (2007). Gastrointestinal diseases. Atlas of non tumour pathology. Washington, DC: American Registry of Pathology.Google Scholar
  5. Odze, R. (2009). Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia, PA: Saunders Elsevier.Google Scholar
  6. Zarovnaya, E. (2005). Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck. Archives of Pathology & Laboratory Medicine, 129, 1032–1036.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaInstituto Português de Oncologia de Lisboa Francisco GentilLisboaPortugal
  2. 2.Serviço de Anatomia PatológicaInstituto Português de Oncologia de Lisboa de Francisco GentilLisbonPortugal
  3. 3.Faculdade de Ciências da SaúdeUniversidade da Beira InteriorCovilhãPortugal