Synonyms
Varioliform gastritis
Definition
Lymphocytic gastritis is a pathological reaction pattern common to a variety of entities (Lash et al.2009). It is characterized by an intense lymphocytic infiltrate in the gastric mucosa with permeation of the foveolar epithelium. It is mainly associated with celiac disease and H. pylori infection but it also complicates Crohn’s disease, HIV infection, Menétrier disease, hypersensitivity reactions, autologous hematopoietic cell transplantation, lymphoma, and esophageal carcinoma (Fenoglio-Preiser et al.2008).
The etiology is still unknown. The strong association with celiac disease and the fact that the intraepithelial lymphocytes are CD8+ T cells have raised the hypothesis of an allergic or autoimmune pathogenesis (Lash et al. 2009).
The most common symptoms are weight loss and anorexia (Lash et al. 2009).
Clinical Features
Incidence
It is seen in 1–4% of patients who undergo upper endoscopy (Lash et al. 2009).
Age
The most frequently affected...
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References and Further Reading
Carmack, S. W., Lash, R. H., Gulizia, J. M., & Genta, R. M. (2009). Lymphocytic disorders of the gastrointestinal tract: A review for the practicing pathologist. Advances in Anatomic Pathology, 16(5), 290–306.
Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). The nonneoplastic stomach. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 197–199). Philadelphia: Lippincott Williams & Wilkins.
Lash, R. H., Lauwers, G. Y., Odze, R. D., & Genta, R. M. (2009). Inflammatory disorders of the stomach. In R. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Saunders.
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Baldaia, H. (2017). Lymphocytic Gastritis. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1648
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1648
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