Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Inflammatory Fibroid Polyp, Upper Gastrointestinal Tract

  • José Manuel LopesEmail author
Reference work entry


Eosinophilic granuloma; Eosinophilic pseudotumor; Granuloblastoma; Submucosal granuloma with eosinophilic infiltration; Vanek’s polyp/tumor


Inflammatory fibroid polyp is a benign submucosal tumor composed of bland spindle and/or stellate mesenchymal cells and edematous/myxoid stroma with prominent vasculature and inflammatory cells comprising eosinophils, lymphocytes, plasma cells, and mast cells (Bhattacharya 2012; Turner and Odze 2009). Despite many ultrastructural and immunohistochemical studies suggesting dendritic, fibroblastic, fibrohistiocytic, histiocytic, myofibroblastic, neural, and vascular differentiation, an origin of spindle cells comprising these polyps remains controversial. The consistent PDGFRA (platelet-derived growth factor receptor alpha) expression seen in gastric and small intestinal inflammatory fibroid polyps points to the fact that these tumors might develop from a subset of PDGFRA-positive mesenchymal cells (Lasota et al. 2009).


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References and Further Reading

  1. Bhattacharya, B. (2012). Non-neoplastic disorders of the stomach. In C. A. Iacobuzio-Doahue & E. Montgomery (Eds.), Gastrointestinal and liver pathology (pp. 130–133). Philadelphia: Saunders Elsevier.Google Scholar
  2. Daum, O., Hatlova, J., Mandys, V., Grossmann, P., Mukensnabl, P., Benes, Z., & Michal, M. (2010). Comparison of morphological, immunohistochemical, and molecular genetic features of inflammatory fibroid polyps (Vanek’s tumors). Virchows Archiv, 456, 491–497.CrossRefGoogle Scholar
  3. Huss, S., Wardelmann, E., Goltz, D., Binot, E., Wolfgang Hartmann, W., Merkelbach-Bruse, S., Buttner, R., & Schildhaus, H.-U. (2012). Activating PDGFRA mutations in inflammatory fibroid polypsoccur in exons 12, 14 and 18 and are associated with tumour localization. Histopathology, 61, 59–68.CrossRefGoogle Scholar
  4. Lasota, J., Wang, Z.-F., Sobin, L. H., & Miettinen, M. (2009). Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases. Modern Pathology, 22, 1049–1056.CrossRefGoogle Scholar
  5. Schildhaus, H.-U., Cavlar, T., Binot, E., Buttner, R., Wardelmann, E., & Merkelbach-Bruse, S. (2008). Inflammatory fibroid polyps harbour mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene. Journal of Pathology, 216, 176–182.CrossRefGoogle Scholar
  6. Solte, M., & Finkenzeller, G. (1990). Inflammatory fibroid polyp of the stomach. Endoscopy, 22, 203–207.CrossRefGoogle Scholar
  7. Turner, J. R., & Odze, R. D. (2009). Polyps of stomach. In R. D. Odze & J. R. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract, and pancreas (pp. 439–441). Philadelphia: Saunders Elsevier.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of PortoPortoPortugal