Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Hyperplastic Polyps (Stomach)

  • Chella R. S. van der PostEmail author
  • Fátima Carneiro
Reference work entry


Gastritis polyposa; Hyperplasiogenic polyp; Inflammatory polyp; Regenerative polyp


Hyperplastic polyps are localized, non-neoplastic mucosal expansions consisting of elongated, tortuous, and cystically dilated foveolae supported by an edematous lamina propria and distended vessels. Hyperplastic polyps arise probably as a result of reparative and regenerative responses to mucosal injury. First there is ongoing healing and a reparative response in the form of foveolar hyperplasia after mucosal injury and erosion. This hyperplastic reaction can end or persist and progress with the formation of a hyperplastic polyp. The common causative agents of mucosal injury are Helicobacter pylori and autoimmune gastritis leading to chronic gastritis, although any agent causing chronic gastritis may be a predisposing condition. H. pylorihas been shown to increase the expression of cyclo-oxygenase-2 (COX-2), interleukin 1-beta, and hepatocyte growth factor in stromal cells, which...

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References and Further Reading

  1. Abraham, S. C., Singh, V. K., Yardley, J. H., & Wu, T. T. (2001). Hyperplastic polyps of the stomach: Associations with histologic patterns of gastritis and gastric atrophy. American Journal of Surgical Pathology, 25(4), 500–507.CrossRefGoogle Scholar
  2. Carneiro, F., David, L., Seruca, R., Castedo, S., Nesland, J. M., & Sobrinho-Simões, M. (1993). Hyperplastic polyposis and diffuse carcinoma of the stomach. A study of a family. Cancer, 72, 323–329.CrossRefGoogle Scholar
  3. Carneiro, F., Santos, L., & Sobrinho-Simões, M. (1995). Carcinoma arising in gastric hyperplastic polyps. Gastrointestinal Endoscopy, 41, 178–179.CrossRefGoogle Scholar
  4. Goddard, A. F., Badreldin, R., Pritchard, D. M., Walker, M. M., Warren, B., & British Society of Gastroenterology. (2010). The management of gastric polyps. Gut, 59(9), 1270–1276.CrossRefGoogle Scholar
  5. Hattori, T. (1985). Morphological range of hyperplastic polyps and carcinomas arising in hyperplastic polyps of the stomach. Journal of Clinical Pathology, 38(6), 622–630.CrossRefGoogle Scholar
  6. Jain, R., & Chetty, R. (2009). Gastric hyperplastic polyps: A review. Digestive Diseases and Sciences, 54(9), 1839–1846.CrossRefGoogle Scholar
  7. Yao, T., Kajiwara, M., Kuroiwa, S., Iwashita, A., Oya, M., Kabashima, A., et al. (2002). Malignant transformation of gastric hyperplastic polyps: Alteration of phenotypes, proliferative activity, and p53 expression. Human Pathology, 33(10), 1016–1022.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
    Email author
  • Fátima Carneiro
    • 2
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands
  2. 2.Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3SPortoPortugal