Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Helicobacter heilmannii Infection

  • Ceu FigueiredoEmail author
Reference work entry


Gastrospirillum hominis; Gastric non-Helicobacter pylori Helicobacter species; “Helicobacter heilmannii”-like organisms (HHLO)


The name “Helicobacter heilmannii” has been used for many years referring to uncultivable, long, spiral-shaped bacteria, morphologically distinct from H. pylori, observed in the stomach of humans and animals. These bacteria were initially designated as “Gastrospirillum hominis” and, based on sequence analysis of the 16S rRNA gene, were provisionally named “Helicobacter heilmannii,” in honor of the German pathologist Konrad Heilmann who first studied the pathology associated with these microorganisms.

H. heilmannii” was further subdivided into two taxa, as phylogenetic analysis of the 16S rRNA gene revealed two types that differed by more than 3% in their nucleotide sequence: “H. heilmannii” type 1, which are morphologically and genetically identical to H. suis (formerly designated “Gastrospirillum suis”), a species that colonizes the...

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References and Further Reading

  1. Haesebrouck, F., Pasmans, F., Flahou, B., Chiers, K., Baele, M., Meyns, T., Decostere, A., & Ducatelle, R. (2009). Gastric Helicobacters in domestic animals and nonhuman primates and their significance for human health. Clinical Microbiology Reviews, 22, 202–223.CrossRefGoogle Scholar
  2. Haesebrouck, F., Pasmans, F., Flahou, B., Smet, A., Vandamme, P., & Ducatelle, R. (2011). Non-Helicobacter pylori Helicobacter species in the human gastric mucosa: A proposal to introduce the terms H. heilmannii sensu lato and sensu stricto. Helicobacter, 16, 339–340.CrossRefGoogle Scholar
  3. Heilmann, K. L., & Borchard, F. (1991). Gastritis due to spiral shaped bacteria other than Helicobacter pylori: Clinical, histological, and ultrastructural findings. Gut, 32, 137–140.CrossRefGoogle Scholar
  4. O’Rourke, J. L., Grehan, M., & Lee, A. (2001). Non-pylori Helicobacter species in humans. Gut, 49, 601–606.CrossRefGoogle Scholar
  5. Stolte, M., Kroher, G., Meining, A., Morgner, A., Bayerdorffer, E., & Bethke, B. (1997). A comparison of Helicobacter pylori and H. heilmannii gastritis. A matched control study involving 404 patients. Scandinavian Journal of Gastroenterology, 32, 28–33.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Pathology, Faculty of Medicine of the University of PortoInstitute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)PortoPortugal