Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Granular Cell Tumor, Gastrointestinal

  • José Manuel LopesEmail author
Reference work entry


Abrikossoff tumor; Granular cell myoblastoma; Granular cell nerve sheath tumor; Granular cell schwannoma


Granular cell tumors comprise a group of variable etiological and clinical tumors characterized by large cells with granular eosinophilic cytoplasm. Myoblasts, Schwann cells, histiocytes, perineural fibroblasts, and undifferentiated mesenchymal cells have been postulated as the origin of the tumor, while theories of the nonneoplastic nature of the lesion resulting from trauma, as a degenerative process or as a storage disorder involving histiocytes, have also been claimed. Recent reports support a peripheral nerve-related cell of origin for the majority of these tumors based on the findings of cytoplasmic granules with numerous membrane-bound vacuoles containing myelin-like tubules and “angulate bodies” that show close relation with preexistent axons at the ultrastructural level, found between granular cells. The expression of nestin in granular cell tumors...

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References and Further Reading

  1. Johnston, J. M., & Helwig, E. B. (1981). Granular cell tumors of the gastrointestinal tract and perianal region. A study of 74 cases. Digestive Diseases and Sciences, 26, 807–816.PubMedGoogle Scholar
  2. Miettinen, M., Fletcher, C. D. M., Kindblom, L.- G., & Tsui, W. M. S. (2010). Mesenchymal tumours of the oesophagus, and colon and rectum. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. E. Theise. (Eds.), WHO classification of tumours of the digestive system (pp. 35–36, and 182, respectively). Lyon: International Agency for Research on Cancer (IARC).Google Scholar
  3. Parfitt, J. R., McLean, C. A., Joseph, M. G., Streutker, C. J., Al-Haddad, S., & Driman, D. K. (2006). Granular cell tumours of the gastrointestinal tract: Expression of nestin and clinicopathological evaluation of 11 patients. Histopathology, 48, 424–430.PubMedGoogle Scholar
  4. Radaeli, F., & Minoli, G. (2009). Granular cell tumors of the gastrointestinal tract: Questions and answers. Gastroenterology and Hepatology, 5, 798–800.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine of the University of Porto and Institute of Molecular Pathology and Immunology of the University of PortoPortoPortugal