Gastric Antral Vascular Ectasia (GAVE)
GAVE was firstly described in 1984, in a report of three cases, as referring to a condition with a characteristic endoscopic antral appearance in which the longitudinal antral folds had visible reddened vessels radiating from the pylorus and therefore resembling the stripes on a watermelon (Jabbari et al. 1984). Usual presentation ranges from occult bleeding (with possible transfusion-dependent anemia) to severe acute GI bleeding. Although etiology remains largely unknown, most patients with GAVE have chronic medical conditions with up to 30% of patients suffering from liver cirrhosis. In case of non-cirrhotic patients, autoimmune diseases have consistently been reported (Selinger and Ang 2008), being autoimmune connective tissue disorders, Raynaud’s phenomenon, and sclerodactyly the most common.
GAVE is considered a rare medical condition that accounts up to 4% of all non-variceal upper GI bleedings.
The mean age...
References and Further Reading
- Montgomery, E. A., & Voltagio, L. (2012). Chapter 2, Stomach. In: Biopsy interpretation of the gastrointestinal tract mucosa. Vol 1: Non-neoplastic. 2nd ed. (pp. 88–89). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
- Westerhoff, M., Tretiakova, M., Hovan, L., Miller, J., Noffsinger, A., & Hart, J. (2010). CD61, CD31, and CD34 improve diagnostic accuracy in gastric antral vascular ectasia and portal hypertensive gastropathy: An immunohistochemical and digital morphometric study. The American Journal of Surgical Pathology, 34(4), 494–501.PubMedGoogle Scholar