Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Granulomatous Gastritis

  • Wen-Yih LiangEmail author
  • Gregory Y. Lauwers
Reference work entry


Granulomatous gastritis is a descriptive diagnosis that encompasses a broad range of conditions characterized by the development of mucosal or submucosal granulomas.

Clinical Features


The development of granulomatous gastritis can be associated with multiple etiologies, including infectious, immune-related, and foreign material, among others (Table 1).
Granulomatous Gastritis, Table 1

Etiologies of granulomatous gastritis



Infectious agents

Tuberculosis (Mycobacterium tuberculosis)

Histoplasma capsulatum

Anisakis (Anisakis simplex)

Taeniasis and Strongyloides stercoralis

Syphilis (Treponema pallidum)

Systemic conditions


Crohn disease

Langerhans cell histiocytosis

Chronic granulomatous disease

Common variable immunodeficiency

Wegener granulomatosis

Foreign bodies

Impacted food, drug coatings

Suture material, barium


Periphery of neoplastic process



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References and Further Reading

  1. Daniels, J. A., et al. (2007). Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): A clinicopathologic study and review. The American Journal of Surgical Pathology, 31(12), 1800–1812.PubMedGoogle Scholar
  2. Ectors, N. L., et al. (1993). Granulomatous gastritis: A morphological and diagnostic approach. Histopathology, 23(1), 55–61.PubMedGoogle Scholar
  3. Koyama, S., et al. (2003). Idiopathic granulomatous gastritis with multiple aphthoid ulcers. Internal Medicine, 42(8), 691–695.PubMedGoogle Scholar
  4. Maeng, L., et al. (2004). Granulomatous gastritis: A clinicopathologic analysis of 18 biopsy cases. The American Journal of Surgical Pathology, 28(7), 941–945.PubMedGoogle Scholar
  5. Sato, Y., et al. (2002). Gastric sarcoid without other sarcoid lesions. Journal of Clinical Gastroenterology, 35(4), 359.PubMedGoogle Scholar
  6. Srivastava, A., et al. (2007). Pathology of non-infective gastritis. Histopathology, 50(1), 15–29.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyTaipei Veterans General HospitalTaipeiTaiwan
  2. 2.Department of PathologyMassachusetts General Hospital, Harvard Medical SchoolBostonUSA