Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Autoimmune Gastritis

  • Chella R. S. van der PostEmail author
  • J. Han van Krieken
Reference work entry


Autoimmune chronic gastritis; Autoimmune metaplastic atrophic gastritis (AMAG); Autoimmune-associated gastritis; Type A gastritis


Autoimmune gastritis is an immune-mediated gastritis, and in its development, anti-parietal cell and anti-intrinsic factor antibodies are involved. There is typical loss of oxyntic cells in the gastric corpus and fundus. Autoimmune gastritis is characterized by hypochlorhydria or achlorhydria, hypergastrinemia, low pepsinogen I/pepsinogen II ratio, and vitamin B12 deficiency that can lead to pernicious anemia. The declining incidence of Helicobacter pylori gastritis parallels a growing clinical focus on autoimmune gastritis.

Hypochlorhydria results from loss of oxyntic mucosa and possibly from the disruption of normal parietal cell maturation. This can already occur in patients with a large number of preserved parietal cells, suggesting that there may be a role for anti-proton pump antibodies or inhibitory lymphokines released by...

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References and Further Reading

  1. Annibale, B., Lahner, E., & Fave, G. D. (2011). Diagnosis and management of pernicious anemia. Current Gastroenterology Reports, 13(6), 518–524.PubMedGoogle Scholar
  2. Odze, R. D., & Goldblum, J. R. (2009). Surgical pathology of the GI tract, liver, biliary tract, and pancreas (2nd ed.). Philadelphia: Saunders.Google Scholar
  3. Rugge, M., Fassan, M., Pizzi, M., Zorzetto, V., Maddalo, G., Realdon, S., et al. (2012). Autoimmune gastritis: Histology phenotype and OLGA staging. Alimentary Pharmacology & Therapeutics, 35(12), 1460–1466.Google Scholar
  4. Torbenson, M., Abraham, S. C., Boitnott, J., Yardley, J. H., & Wu, T. T. (2002). Autoimmune gastritis: Distinct histological and immunohistochemical findings before complete loss of oxyntic glands. Modern Pathology, 15(2), 102–109.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Chella R. S. van der Post
    • 1
    Email author
  • J. Han van Krieken
    • 1
  1. 1.Department of PathologyRadboud University Medical CenterNijmegenThe Netherlands