Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Juvenile Polyp, Upper Gastrointestinal Tract

  • Helena BaldaiaEmail author
Reference work entry


Juvenile polyps are hamartomatous polyps of the gastrointestinal (GI) tract. As such, they are composed of indigenous elements to the site of origin, although arranged in a malformed manner.

Juvenile polyps can appear as solitary sporadic polyps of the colon or, less frequently, in the context of a generalized polyposis syndrome, juvenile polyposis (JP). The diagnostic criteria established for juvenile polyposis are:
  1. 1.

    More than three to five juvenile polyps of the colorectum

  2. 2.

    Juvenile polyps throughout the gastrointestinal tract

  3. 3.

    Any number of juvenile polyps with a family history of juvenile polyposis (Offerhaus and Howe 2010)


JP can be clinically divided into three subtypes. The rare juvenile polyposis of infancyis a generalized polyposis syndrome usually diagnosed before the age of 2. These infants suffer from diarrhea, hemorrhage, malnutrition, and intussusception. Death occurs at an early age, and many of these patients have associated congenital anomalies...

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References and Further Reading

  1. Brosens, L. A., Langeveld, D., van Hattem, W., et al. (2011). Juvenile polyposis syndrome. World Journal of Gastroenterology, 28(17), 4839–4844.CrossRefGoogle Scholar
  2. Calva, D., & Howe, J. (2008). Hamartomatous polyposis syndromes. The Surgical Clinics of North America, 88(4), 779.CrossRefGoogle Scholar
  3. Fenoglio-Preiser, C. M., Noffsinger, A. E., Stemmermann, G. N., Lantz, P. E., & Isaacson, P. G. (2008). Polyposis and hereditary cancer syndromes. In J. McGouh & J. Pine (Eds.), Gastrointestinal pathology an atlas and text (pp. 704–724). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  4. Gammon, A., Jasperson, K., Kohlmann, W., & Burt, R. W. (2009). Hamartomatous polyposis syndromes. Best Practice & Research Clinical Gastroenterology, 23(2), 219–231.CrossRefGoogle Scholar
  5. Hornick, J. L., & Odze, R. D. (2009). Polyps of the large intestine. In R. Odze & J. Goldblum (Eds.), Surgical pathology of the GI tract, liver, biliary tract and pancreas. Philadelphia: Saunders.Google Scholar
  6. Iacobuzio-Donahue, C. A. (2012). Gastrointestinal polyposis syndromes. In C. A. Iacobuzio-Donahue, E. Montgomary, & J. R. Golblum (Eds.), Gastrointestinal and liver pathology (pp. 399–402). Philadelphia: Saunders.Google Scholar
  7. Offerhaus, G. J. A., & Howe, J. R. (2010). Juvenile polyposis. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 166–167). Lyon: IARC.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal