Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Solitary Rectal Ulcer Syndrome

  • Andrzej MrózEmail author
Reference work entry


Mucosal prolapse syndrome – part of; SRUS


Solitary rectal ulcer syndrome (SRUS) is the part of the spectrum of mucosal prolapse syndrome. It affects mainly young females with defecation problems and changed bowel habits. Excessive and prolonged straining on defecation leads to rectal mucosal prolapse with secondary ulceration and polypoid lesions development. Anterior wall of the rectum is particularly vulnerable to prolapse on straining, since it is physiologically redundant. Most of SRUS cases locate at the anterior wall of the rectum. While the mucosa is impacted to anal canal, it may become ischemic due to obliteration of mucosal vessels. Patients with SRUS have rectal bleeding, diarrhea, anorectal pain, pruritus, abdominal pain, and difficulty in defecating. These include constipation, straining, increased laxative use, and incomplete rectal evacuation.

SRUS is a misnomer – patients may have no ulceration and the lesions may be multiple.

Clinical Features

  • Incidence...

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References and Further Reading

  1. Iacobuzio-Donahue, C. A., & Montgomery, E. (2005). Gastrointestinal and liver pathology. Philadelphia: Elsevier.Google Scholar
  2. Noffsinger, A., et al. (2007). Gastrointestinal diseases. Washington, DC: The American Registry of Pathology.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Gastroenterology and HepatologyHistopathology Unit, Medical Center for Postgraduate EducationWarsawPoland