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Pathology of the Gastrointestinal Tract pp 538–541Cite as

Neuroendocrine Tumor, Colon and Rectum

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Carcinoid tumor; Endocrine neoplasm; Neuroendocrine carcinoma; Neuroendocrine neoplasm

Definition

Neuroendocrine neoplasia (NEN) is a general term including broad family of neoplasms originating in neural and endocrine structures. NEN may be localized in pure endocrine organs (thyroid, parathyroid, and adrenal glands), nerve plexuses, extraadrenal paraganglia (paragangliomas), and diffuse endocrine system in different organs including gastrointestinal tract. Fourteen different cell types, producing variety of hormones, have been described as components of diffuse endocrine system. Neuroendocrine cells of diffuse endocrine system that give rise to gastrointestinal NENs are endodermally derived and originate from gastrointestinal stem cells. Neuroendocrine cells and their neoplastic counterparts secrete peptide hormones and biogenic amines. Besides, with electron microscopy, typical large neurosecretory granules and small synaptic like vesicles are shown in their cytoplasm....

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References and Further Reading

  • Caplin, M., Sundin, A., Nillson, O., Baum, R. P., Klose, K. J., Kelestimur, F., Plöckinger, U., Papotti, M., Salazar, R., Pascher, A., all other Barcelona Consensus Conference participants. (2012). ENETS consensus guidelines for the management of patients with digestive neuroendocrine neoplasms: Colorectal neuroendocrine neoplasms. Neuroendocrinology, 95, 88–97.

    Article  CAS  Google Scholar 

  • Klimstra, D. S. (2016). Pathologic classification of neuroendocrine neoplasms. Hematology/Oncology Clinics of North America, 30, 1–19.

    Article  Google Scholar 

  • Klimstra, D. S., Arnold, R., Capella, C., Kloppel, G., Komminoth, P., Solcia, E., & Rind, G. (2010). Neuroendocrine neoplasms of the colon and rectum. In T. F. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumors of the digestive system (pp. 174–177). Lyon: International Agency for Research on Cancer.

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  • Kloppel, G. (2011). Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms. Endocrine-Related Cancer, 18, S1–S16.

    Article  Google Scholar 

  • Kloppel, G., Rindi, G., Anlauf, M., Perren, A., & Komminoth, P. (2007). Site specific biology and pathology of gastroenteropancreatic neuroendocrine tumors. Virchows Archiv, 451(suppl 1), S9–S27.

    Article  Google Scholar 

  • Rindi, G., & Wiedenmann, B. (2012). Neuroendocrine neoplasms of the gut and pancreas: New insights. Nature Reviews Endrocrinology, 8, 54–64.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Dokuz Eylul University Medical School, Inciralti, Izmir, Turkey

    Ozgul Sagol

Authors
  1. Ozgul Sagol
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Corresponding author

Correspondence to Ozgul Sagol .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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Sagol, O. (2017). Neuroendocrine Tumor, Colon and Rectum. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1516

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1516

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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