Synonyms
High-grade mucinous adenocarcinoma; Well-differentiated mucinous adenocarcinoma
Definition
An appendiceal adenocarcinoma is a malignant epithelial neoplasm of the appendix with invasion beyond the muscularis mucosae.
In the current UICC/AJCC TNM staging (7th edition, 2010), appendiceal adenocarcinomas are separated into mucinous and non-mucinous types (UICC/AJCC TNM staging 2010). Indeed, the 5-year survival of appendiceal mucinous adenocarcinomas with distant metastasis is significantly better than those of non-mucinous carcinomas. This is reflected in the staging considerations for metastatic tumors.
Macroscopically, mucinous adenocarcinomas of the appendix can be cystic or not. The term “mucinous cystadenocarcinoma” may be used for well-differentiated mucinous adenocarcinomas with cystic structures. However, the distinction between a cystic carcinoma (i.e., cystadenocarcinoma) and one that is not cystic has not been shown to be of biologic significance. Therefore, this...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Carr, N. J., & Sobin, L. H. (2010). Tumours of the appendix. In F. T. Bosman, F. Carneiro, R. H. Hruban, & N. D. Theise (Eds.), WHO classification of tumours of the digestive system (pp. 122–125). Lyon: IARC Press.
Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., & Trotti, A. (2010). Appendix. In AJCC Cancer Staging Handbook, from the AJCC cancer staging manuel, (7th ed., pp. 161–171). New York: Springer.
National Cancer Institute Monograph 57. (1981). Surveillance, epidemiology, and end results: Incidence and mortality data, 1973–77 (NIH Publication No. 81–2330). Bethesda: US. Department of Health and Human Services.
Sugarbaker, P. H. (2009). Comprehensive management of peritoneal surface malignancy using cytoreductive surgery and perioperative intraperitoneal chemotherapy: The Washington Cancer Institute approach. Expert Opin Pharmacother, 10, 1965–1977.
Thomas, R. M., & Sobin, L. H. (1995). Gastrointestinal cancer. Cancer, 75, 154–170.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this entry
Cite this entry
Svrcek, M. (2017). Mucinous Cystadenocarcinoma, Appendix. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1512
Download citation
DOI: https://doi.org/10.1007/978-3-319-40560-5_1512
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40559-9
Online ISBN: 978-3-319-40560-5
eBook Packages: MedicineReference Module Medicine