Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Intestinal Atresia

  • Andrzej MrózEmail author
Reference work entry


Intestinal atresia and stenosis


Intestinal atresia is a complete blockage of intestinal passage caused by mucosal diaphragm which totally occludes the lumen. Stenosis is formed by narrowed segment of the intestine or the mucosal diaphragm with small opening. Intestinal atresia and stenosis are responsible for most cases of bowel obstruction in newborns.

There are three major theories explaining development of intestinal atresia:
  1. (i)

    Failed recanalization of the intestine during 12-th fetal week

  2. (ii)

    Retarded epithelial growth during intestinal elongation which is slower than mesenchymal growth

  3. (iii)

    Vascular abnormalities in utero leading to ischemia and segmental necrosis with subsequent scaring and development of atresia

Intestinal atresia differs in its clinical picture, diagnosis, and treatment methods, depending on the site of the involvement, which can be divided in duodenal, ileojejunal, and colon atresia. This condition is connected with prematurity in...
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References and Further Reading

  1. Dalla Vecchia, L. K., Grosfeld, J. L., et al. (1998). Intestinal atresia and stenosis: 25-year experience with 277 cases. Archives of Surgery, 133, 490.CrossRefGoogle Scholar
  2. Fenoglio-Preiser, C., et al. (1999). Gastrointestinal pathology plus: An atlas and text. Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  3. Prasad, T. R., & Bajpai, M. (2000). Intestinal atresia. Indian Journal of Pediatrics, 67, 671–678.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Gastroenterology and Hepatology, Histopathology UnitMedical Center for Postgraduate EducationWarsawPoland