Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Inflammatory Fibroid Polyp, Lower Gastrointestinal Tract

  • Berna SavaşEmail author
Reference work entry


Eosinophilic submucosal granuloma; Vanek’s tumor


Inflammatory fibroid polyp (IFP) is a rare mesenchymal lesion of the gastrointestinal tract first described by Vanek in 1949. In 1953, Helwig and Ranier proposed the term “inflammatory fibroid polyp,” which is generally accepted at present. IFPs are most commonly found in the stomach but can occur throughout the GI tract and in one series were more prevalent in the small bowel. IFPs have been reported in different sites, such as the esophagus, duodenum, and ileoanal pouch, but they occur relatively rare in colorectum.

Presenting symptoms can vary and may include abdominal pain, weight loss, and symptoms of GI obstruction or intussusception. IFP may also present as an incidental finding on routine endoscopic examination. IFPs may be associated with concurrent neoplastic (carcinoma, adenomatous polyps) and non-neoplastic (usually inflammatory) lesions of the GI tract.

Clinical Features

  • Incidence

    IFPs are very rare...

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References and Further Reading

  1. Daum, O., Hes, O., Vanecek, T., et al. (2003). Vanek’s tumor (inflammatory fibroid polyp). Report of 18 cases and comparison with three cases of original Vanek’s series. Annals of Diagnostic Pathology, 7, 337–347.CrossRefGoogle Scholar
  2. Daum, O., Hatlova, J., Mandys, V., et al. (2010). Comparison of morphological, immunohistochemical, and molecular genetic features features of inflammatory fibroid polyp (Vanek’s polyp). Virchows Archiv, 426, 491–496.CrossRefGoogle Scholar
  3. Miettinen, M., Fletcher, C. D. M., Kindblom, L. -G., & Tsui, W. M. S. (2010). World Health Organization classification of tumours. Pathology & genetics. Tumours of the digestive system. In F. T. Bosman, F. Carnerio, R. H. Hruban, & N. D. Theise (Eds.), Mesencymal tumours of the small intestine (pp. 115–118). Lyon: International Agency for research on cancer (IARC).Google Scholar
  4. Ozolek, J. A., Sasatomi, E., Swalsky, P. A., et al. (2004). Inflammatory fibroid polyps of the gastrointestinal tract clinical, pathologic, and molecular characteristics. Applied Immunohistochemistry & Molecular Morphology, 12, 59–66.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of PathologyAnkara University Medical SchoolAnkaraTurkey