Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Inflammatory Cloacogenic Polyp

  • Chatelain DenisEmail author
  • Jean-François Fléjou
Reference work entry


Polypoid variant of solitary rectal ulcer


The inflammatory cloacogenic polyp is a benign polypoid lesion of the anal transitional zone (ATZ). It is included into the mucosal prolapse syndrome with other conditions, with which it shares some histological and pathogenic features, such as the solitary rectal ulcer, the colitis cystic profunda, the inflammatory myoglandular polyp, and the cap polyp and polyposis.

Cloacogenic polyp is considered as a result of nonspecific regenerative changes of the anorectal mucosa caused by recurrent prolapse, or mucosal injury. It could result from mucosal ischemia and regenerative changes secondary to anal mucosal prolapse, caused by constipation, chronic disorders of defecation, and inappropriate puborectalis muscle contractions. The same type of changes can also be seen in other situations with mucosal prolapse, such as colonic intussusceptions, prolapsed colostomies, prolapsed hemorrhoids, prolapsing polyps in association with...

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References and Further Reading

  1. Du Boulay, C. E., Fairbrother, J., & Isaacson, P. G. (1983). Mucosal prolapse syndrome – A unifying concept for solitary ulcer syndrome and related disorders. Journal of Clinical Pathology, 36, 1264–1268.CrossRefGoogle Scholar
  2. Hanson, I. M., & Armstrong, G. R. (1999). Anal intraepithelial neoplasia in an inflammatory cloacogenic polyp. Journal of Clinical Pathology, 52, 393–594.CrossRefGoogle Scholar
  3. Lobert, P. F., & Appelman, H. D. (1981). Inflammatory cloacogenic polyp. A unique inflammatory lesion of the anal transitional zone. The American Journal of Surgical Pathology, 5, 761–766.CrossRefGoogle Scholar
  4. Saul, S. H. (1987). Inflammatory cloacogenic polyp: Relationship to solitary rectal ulcer syndrome/mucosal prolapse and other bowel disorders. Human Pathology, 18, 1120–1125.CrossRefGoogle Scholar
  5. Singh, B., Mortensen, N. J., & Warren, B. F. (2007). Histopathological mimicry in mucosal prolapse. Histopathology, 50, 97–102.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Service d’Anatomie PathologiqueCentre Hospitalier et Universitaire du NordAmiensFrance
  2. 2.Faculté de Médecine Pierre et Marie Curie, Service d’Anatomie et Cytologie PathologiquesHôpital Saint-AntoineParisFrance