Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Inflammatory Bowel Disease

  • Karel GeboesEmail author
Reference work entry


Chronic idiopathic inflammatory bowel diseases; IBD


Inflammatory bowel diseases (IBD) is a group of chronic idiopathic inflammatory conditions that affect mainly the small intestine and the colon. The two major types are ulcerative colitis (UC) and Crohn’s disease (CD). There is a genetic predisposition for IBD, and patients with this condition are more prone to the development of malignancy. Further types to be considered are indeterminate colitis (IC) and inflammatory bowel disease unclassified (IBDU). These are essentially “temporary diagnoses” when the difference between UC and CD cannot be established definitely at the time of presentation. IC should be used when examination of surgical samples is available together with clinical, serological, and imaging data, while IBDU is used for patients from whom only endoscopic biopsy samples are available. Many of the patients classified as “Indeterminate Colitis” present clinically with severe disease. Other chronic...

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References and Further Reading

  1. Binder, V. (2004). Epidemiology of IBD during the twentieth century: An integrated view. Best Practice & Research Clinical Gastroenterology, 18, 463–479.CrossRefGoogle Scholar
  2. Geboes, K., Colombel, J. F., Greenstein, A., Jewell, D., Sandborn, W., Vatn, M., Warren, B., & Riddell, R. H. (2008). Indeterminate colitis: A review of the concept – What’s in a name? Inflammatory Bowel Diseases, 14, 860–867.CrossRefGoogle Scholar
  3. Jenkins, D., Balsitis, M., Gallivan, S., Dixon, M. F., Gilmour, H. M., Shepherd, N. A., Theodossi, A., & Williams, G. T. (1997). Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative. Journal of Clinical Pathology, 50, 93–105.CrossRefGoogle Scholar
  4. Münch, A., Aust, D., Bohr, J., Bonderup, O., Fernandez Banares, F., Hjortswang, H., Madisch, A., Munck, L. K., Ström, M., Tysk, C., & Miehlke, S. (2012). Microscopic colitis: Current status, present and futures challenges. Journal of Crohn’s and Colitis, 8, 932–945.CrossRefGoogle Scholar
  5. Silverberg, M., Satsangi, J., Ahmad, T., Arnott, I. D. R., Bernstein, C. N., Brant, S. R., Caprilli, R., Colombel, J. F., Gasche, C., Geboes, K., Jewell, D., Karban, A., Loftus, E. V., Pena, A. S., Riddell, R. H., Sachar, D. B., Schreiber, S., Steinhart, A. H., Targan, S. R., Vermeire, S., & Warren, B. F. (2005). Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a working party of the 2005 Montreal World congress of Gastroenterology. Canadian Journal of Gastroenterology, 19(Suppl A), 5–36.CrossRefGoogle Scholar
  6. Vermeire, S. (2012). Towards a novel molecular classification of IBD. Digestive Diseases, 30, 425–427.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Pathology, N. Goormaghtig InstituteUniversity GentGentBelgium
  2. 2.Department of PathologyKU LeuvenLeuvenBelgium