Abstract
Specific skin changes in severe acute malnutrition have been known since the earliest publication on the subject in 1933. They vary from mild dryness or pigmentary changes to severe and widespread erosions. A common standardized way to document the skin changes observed in severe acute malnutrition is still under development. Currently five specific skin changes, characteristic to severe acute malnutrition, have been identified in African children. There is no knowledge of the global prevalence, but most reports on severe skin affections are from sub-Saharan countries.
The etiology is still unknown and the recommendations on treatment are mostly based on expert opinion. Skin changes in severe acute malnutrition have proven to be a prognostic marker for the risk of death. The mortality rate for patients treated for severe acute malnutrition is persistently high and thus the skin is a target for new treatment approaches. The skin is easily accessible for administration of treatment and assessment and is potentially a good additional target to the existing treatment protocols.
Similar content being viewed by others
Abbreviations
- BSA:
-
Body surface area
- SCORDoK:
-
Clinical score for SAM specific skin changes
- EFAD:
-
Essential Fatty Acid Deficiency
- HR:
-
Hazard ratio
- MUAC:
-
Mid Upper Arm Circumference
- F75 and F100:
-
Milk based therapeutic diets
- SAM:
-
Severe acute malnutrition
References
Amadi B, Fagbemi AO, Kelly P, Mwiya M, Torrente F, Salvestrini C, Day R, Golden MH, Eklund EA, Freeze HH, Murch SH (2009) Reduced production of sulfated glycosaminoglycans occurs in Zambian children with kwashiorkor but not marasmus. Am J Clin Nutr 89:592–600
Ashworth A (2005) Pocket book of hospital care for children: guidelines for the management of common illnesses with limited resources. World Health Organization, Geneva
Ashworth A, Khanum S, Jackson A, Schofield C (2003) Guidelines for the inpatient treatment of severely malnourished children. World Health Organization, Geneva
Becker K, Pons-Kühnemann J, Fechner A, Funk M, Gromer S, Gross H-J, Grünert A, Schirmer RH (2005) Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor -a pilot study. Redox Rep 10(4):215–226
Bradfield RB (1972) A rapid tissue technique for the field assessment of protein-caloric malnutrition. Am J Clin Nutr 25(7):720–729
Bradfield RB, Bailey MA, Cordano A (1968) Hair-root changes in Andean Indian children during marasmic kwashiorkor. Lancet 30(2):1169–1170
Braun-Falco O, Plewig G, Wolff HH, Burgdorf WHC (2009) Dermatology, 3rd edn. Springer, Heidelberg
Collins F, Sinclair A, Royle J, Coats D, Maynard A, Leonard R (1971) Plasma lipids in human linoleic acid deficiency. Nutr Metab 1971(13):150–167
Giovanni V, Bourdon C, Wang DX, Seshadri S, Senga E, Versloot CJ, Voskuijl W, Semba RD, Trehan I, Moaddel R, Ordiz MI, Zhang L, Parkinson J, Manary M, Bandsma RHJ (2016) Metabolomic changes in serum of children with different clinical diagnoses of malnutrition. J Nutr 146(12):2436–2444
Golden BE, Golden MH (1979) Plasma zinc and the clinical features of malnutrition. Am J Clin Nutr 32(12):2490–2494
Golden M, Grellety Y (2012) Protocol -Integrated management of acute malnutrition version 6.6.2
Golden MH, Golden BE, Jackson AA (1980) Skin breakdown in kwashiorkor responds to zinc. Lancet 1(8180):1256
Ground KEU (1957) The dermatosis associated with kwashiorkor in Basutoland. Trans R Soc Trop Med Hyg 51(5):433–438
Hegyi J, Schwartz RA, Hegyi (2004) Pellagra: dermatitis, dementia, and diarrhea. Int J Derm 43:1–5
Heilskov S, Rytter MJH, Vestergaard C, Briend A, Babirekere E, Deleuran MS (2014) Dermatosis in children with oedematous malnutrition (kwashiorkor): a review of the literature. J Eur Acad Dermatol Venereol 28(8):995–1001
Heilskov S, Vestergaard C, Babirekere E, Namusoke H, Rytter MJH, Deleuran MS (2015) Characterization and scoring of skin changes in severe acute malnutrition in children between 6 months and 5 years of age. J Eur Acad Dermatol Venereol 29(12):2463–2469
Jahoor F (2012) Effects of decreased availability of sulfur amino acids in severe childhood undernutrition. Nutr Rev 70(3):176–187
Jahoor F, Badaloo A, Reid M, Forrester T (2008) Protein metabolism in severe childhood malnutrition. Ann Trop Paediatr 28(2):87–101
Leichsenring M, Sütterlin N, Less S, Bäumann K, Anninos A, Becker K (1995) Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta Paediatr 84(5):516–520
Maltos AL, Portari GV, Moraes GV, Monteiro MCR, Vanucchi H, da Cunha DF (2015) Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis. Nutrition 31:890–892
McLaren DS, Shirajian E, Loshkajian H, Shadarevian S (1969) Short-term prognosis in protein-calorie malnutrition. Am J Clin Nutr 22(7):863–870
Milner JA (1979) Assessment of the essentiality of methionine, threonine, tryptophan, histidine and isoleucine in immature dogs. J Nutr 109(8):1351–1357
Proksch E, Feingold KR, Man MQ, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87(5):1668–1673
Rangam CM, Bhagwat AG, Gupta JC (1962) Cutaneous lesions in kwashiorkor. A histopathological and histochemical study. Indian J Med Res 50:184–190
Roediger WE (1995) New views on the pathogenesis of kwashiorkor: methionine and other amino acids. J Pediatr Gastroenterol Nutr 21(2):130–136
Salam RA, Das JK, Darmstadt GL, Bhutta ZA (2013) Emollient therapy for preterm newborn infants – evidence from the developing world. BMC Public Health 13(Suppl3):S31
Sims RT (1968) The ultrastructure of depigmented skin in kwashiorkor. Br J Dermatol 80(12):822–832
Stannus H (1935) Kwashiorkor. Lancet 2:1207
Thavaraj V, Sesikeran B (1989) Histopathological changes in skin of children with clinical protein energy malnutrition before and after recovery. J Trop Pediatr 35(3):105–108
Trowell HC (1954) Clinical aspects of the treatment of kwashiorkor. Ann N Y Acad Sci 57(6):722–733
Vasantha L (1969) Labile collagen content in the skin in kwashiorkor. Clin Chim Acta 26(2):277–280
Vasantha L, Srikantia SG, Gopalan C (1970) Biochemical changes in the skin in kwashiorkor. Am J Clin Nutr 23(1):78–82
Waterlow JC, Tomkins A, Grantham-McGregor SM (2006) Protein-energy malnutrition. Smith-Gordon, New Barnet
WHO (2013) Updates on the management of severe acute malnutrition in infants and children. World Health Organization, Geneva
WHO, UNICEF (2009) WHO child growth standards and the identification of severe acute malnutrition in infants and children -a joint statement by the World Health Organization and the United Nations Children’s fund. World Health Organization, Geneva
Williams CD (1933) A nutritional disease of childhood associated with a maize diet. Arch Dis Child 8(48):423–433
Williams ML (1992) Ichthyosis: mechanisms of disease. Pediatr Derm 9(4):365–368
Wolff JA, Margolis S, Bujdoso-Wolff K, Matusick E, MacLean WC Jr (1984) Plasma and red blood cell fatty acid composition in children with protein-calorie malnutrition. Pediatr Res 18(2):162–167
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this entry
Cite this entry
Heilskov, S., Vestergaard, C., Deleuran, M.S. (2017). Defining and Assessing Skin Changes in Severe Acute Malnutrition (SAM). In: Preedy, V., Patel, V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-40007-5_12-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-40007-5_12-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40007-5
Online ISBN: 978-3-319-40007-5
eBook Packages: Springer Reference MedicineReference Module Medicine