Definition
In its original, and most widely used form, isotope dilution is a method for determining elemental concentrations in samples of minerals, rocks, and fluids. It involves adding a known quantity of an enriched isotope “spike” to the (usually dissolved) sample, followed by isotopic analysis of the resulting spike-sample mixture in an isotope ratio mass spectrometer. One of the main applications of the technique is in radiometric age determinations (geochronology ) where the concentrations of parent and daughter isotopes must be measured in order to calculate the geological age of a sample. The concept has evolved further, with the development of double- and triple-spikes composed of multiple enriched isotopes. These more complex variants are designed to allow the monitoring and correction of instrumental mass bias effects encountered during mass spectrometric isotope ratio measurements of many different elements, allowing the...
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References
Alonso JIG, Rodriguez-Gonzalez P (2013) Isotope dilution mass spectrometry. Royal Society of Chemistry, Cambridge
Creech JB, Paul B (2014) IsoSpike: improved double spike inversion software. Geostand Geoanal Res 39:7–15
Dodson MH (1963) A theoretical study of the use of internal standards for precise isotopic analysis by the surface ionization technique: part I – general first-order algebraic solutions. J Sci Instrum 40:289–295
Hamelin B, Manhes G, Albarede F, Allegre CJ (1985) Precise lead isotope measurements by the double spike technique: a reconsideration. Geochim Cosmochim Acta 49:173–182
Hevesy G, Hofer E (1934) Elimination of water from the human body. Nature 134:879
Rittenberg D, Foster GJ (1940) A new procedure for quantitative analysis by isotope dilution with application to the determination of amino acids and fatty acids. J Biol Chem 133:737–744
Rudge JF, Reynolds BC, Bourdon B (2009) The double spike toolbox. Chem Geol 148:95–104
Stracke A, Scherer EE, Reynolds BC (2014) Application of isotope dilution in geochemistry. Treatise Geochem 2nd edition 15:71–86. doi:10.1016/B978-0-08-095975-7.01404-2
Taylor RN, Ishizuka O, Michalik A, Milton JA, Croudace IW (2015) Evaluating the precision of Pb-isotope measurement by mass spectrometry. J Anal At Spectros 30:198–213
Webster RK (1960) Mass spectrometric isotope dilution analysis. In: Smales AA, Wager LR (eds) Methods in geochemistry. Interscience Publishers, New York, pp 202–246
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Woodhead, J. (2017). Isotope Dilution. In: White, W. (eds) Encyclopedia of Geochemistry. Encyclopedia of Earth Sciences Series. Springer, Cham. https://doi.org/10.1007/978-3-319-39193-9_241-1
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DOI: https://doi.org/10.1007/978-3-319-39193-9_241-1
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