Neuroendocrinology of Bone Metabolism
Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. As a matter of fact, skeletal fragility associated with high risk of fractures is a common complication of pituitary diseases characterized by either hypo- or hyperfunction of the pituitary gland. This chapter deals with physiological, pathophysiological, clinical, and therapeutic aspects concerning the effects of pituitary hormones on skeletal health.
KeywordsPituitary diseases Osteoporosis Bone mineral density Fractures Growth hormone Prolactin Cortisol Sex steroids
- Biller BMK, Sesmilo G, Baum HBA, Hayden D, Schoenfeld D, Klibanski A. Withdrawal of long-term physiological growth hormone (GH) administration: differential effects on bone density and body composition in men with adult-onset GH deficiency. J Clin Endocrinol Metab. 2000;85:970–6.PubMedGoogle Scholar
- Mazziotti G, Sorvillo F, Piscopo M, et al. Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma. J Bone Miner Res. 2005;20:480–6.PubMedCrossRefGoogle Scholar
- Ueland T, Bollerslev J, Flyvbjerg A, et al. Effects of 12 months of growth hormone (GH) treatment on cortical and trabecular bone content of insulin like growth factors (IGF) and osteoprotegerin in adults with acquired GH deficiency: a double-blind, randomized, placebo-controlled study. J Clin Endocrinol Metab. 2002;87:2760–3.PubMedCrossRefGoogle Scholar