Mild Cognitive Impairment (MCI)
Currently it is accepted that the DSM-5 mild neurocognitive dementia (NCD) is derived from research on mild cognitive impairment (MCI). Several labels have been used to categorise non-disabling memory deficits in the elderly. Unlike age-associated memory decline (AAMI), MCI is assumed to have a pathological basis and is at high risk of developing dementia, more than half progressing to dementia within 5 years. MCI has now been expanded to include other cognitive domains and other potential causes like normal ageing, frontotemporal dementia and vascular dementia. Nonamnestic forms may be due to cerebrovascular disease, Parkinson’s disease, Lewy body dementia and frontotemporal dementia amongst others.
KeywordsMild neurocognitive dementia Mild cognitive impairment Age-associated memory decline Nonamnestic forms Amnestic forms
- 9.Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz US, Boeve BF, et al. The incidence of mild cognitive impairment differs by subtype and is higher in men. Neurology. 2012. WNL 0b013e3182452862.Google Scholar
- 10.Larrabee GJ, Crook T. Estimated prevalence of ageassociated memory impairment, derived from standardised tests of memory function. Int Psychogeriatr. 1994;6:95–104.Google Scholar
- 22.Defrancesco M, Marksteiner J, Deisenhammer EA, Hinterhuber H, Weiss EM. Associated mild cognitive impairment (MCI) and depression. Neuropsychiatry. 2009;23(3):144–50.Google Scholar
- 25.Koivistok K, Reinkainen KJ, Hanninen T, Vanhanan M, Helkala EL, Mykkanen L, et al. Prevalence of age associated memory impairment in a randomly selected population from eastern Finland. Neurology 1995;45:745–74.Google Scholar
- 27.Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004;256183–194.194.Google Scholar
- 30.Risacher SL, Saykin AJ, West JD, Shen L, Firpi HA, McDonald BC, Alzheimer Disease Neuroimaging Initiative (ADNI). Baseline MRI prediction of conversion of from mild cognitive impairment to probable Alzheimer’s disease in the ADNI cohorts. Curr Alzheimer Res. 2009;6(4):347–361.CrossRefPubMedPubMedCentralGoogle Scholar
- 34.Jeon SY, Han SJ, Jeong JH, Felipe F. Effect of exercise on balance in persons with mild cognitive impairment. Neurorehab 2004;35(2):271–278.Google Scholar
- 35.Bahureksa L, Najafi B, Salen A, Sabbagh M, Coon D, Monier MJ, et al. The impact of mild cognitive impairment on gait balance: a systematic review and meta-analysis of studies using instrumental assessment. Gerontology. 2007;63:678336.Google Scholar
- 36.Girdwain J. The gait and cognitive decline connection. Aging well.6(1). p6. www.todaysgeriatricmedicine.com/archive/011613pdf.shtml. Accessed 13 January 2017.
- 38.Shin BM, Han SJ, Jung JH, Kim JE, Fregni I. Effect of mild cognitive impairment on balance. DOI: https://doi.org/10.1016/j.ins.2011.02.031. Accessed 13 January 2017.
- 39.Sarabo-Cobo CM, Garcia-Rodriguez D, Navas J, Ellgrng H. Emotional processing in patients with mild cognitive impairment: influence of the balance and intensity of emotional stimuli. https://doi.org/10.1016/j.ins.2015.07.034.
- 40.Rusconi ML, Suardi A, Zanetti M, Rozeini L. Spatial navigation in elderly healthy subjects, amnestic and nonamnestic mild cognitive impairment patients. https://doi.org/10.1016/j.ins.2015.10.010. Accessed 13 January2017.