• Nages Nagaratnam
  • Kujan Nagaratnam
  • Gary Cheuk
Reference work entry


Their clinical features include spinal symptoms, peripheral arthritis and enthesopathic lesions. Severe spinal disease is more often seen in males and peripheral joint involvement in females. Late-onset peripheral spondyloarthropathy (LOPS) is characterised by severe disease, markedly raised inflammatory markers, oligoarthritis and oedema of the extremities, and HLA-B27 is positive. Late-onset psoriatic spondyloarthropathy shares a number of characteristics with late-onset spondyloarthropathy not seen in spondyloarthropathy patients of younger onset.


Spondyloarthropathy Late-onset peripheral spondyloarthropathy Late-onset psoriatic spondyloarthropathy Enthesopathic lesions 


  1. 1.
    Hmamouchi I, Bahiri R, Hajjaj-Hassouni N. Clinical and radiological presentation of late-onset spondyloarthritis. Rheumatology. Volume 2011.
  2. 2.
    Kahn MA, van der Linden SM: A wider spectrum of spondyloarthropathies. Semin Arthritis Rheum. 1990;20:107–43.CrossRefGoogle Scholar
  3. 3.
    Olivieri L, Van Tubergen A, Salvarani C, van der Linden S. Seronegative spondyloarthritides. Best Pract Recs Clin Rheumatol. 2002;16:723–39.CrossRefGoogle Scholar
  4. 4.
    Toussirot E, Wendling D. Late-onset ankylosing spondylitis and related spondyloarthropathies: clinical and radiological characteristics and pharmacological treatment options. Drugs Aging. 2005;22(6):451–69.CrossRefPubMedGoogle Scholar
  5. 5.
    Dougados, van der Linden S, Juhlin R, Huitfedt B, Amor B, Calin A, et al. The European Spondyloarthropathy Study Group preliminary criteria for the classification of spondyloarthropathy. Arthritis Rheum. 1991;34:1218–27.CrossRefPubMedGoogle Scholar
  6. 6.
    Haglund E, Bremander A, Petersson I, Strombeck B, Bergman S, Jacobsson L, et al. Prevalence of spondyloarthritis and its subtypes in southern Sweden. Annals Rheumatic Dis. 2011;70:943–948.CrossRefGoogle Scholar
  7. 7.
    Queiro R, Tejon P, Coto P, Alonso S, Alperi M, Sarasqueta C, et al. Clinical differences between men and women with psoriatic arthritis: relevance of the analysis of genes and polymorphisms in the major histocompatibility complex region and of the age at onset of psoriasis. Clin Dev Imunol. 2013. accessed on 28 January 2016.
  8. 8.
    Van der Linden SM, Valkenburg HA, de Jongh BM, Cats A. The risk of developing ankylosing spondylitis inHKA-B27 positive individuals. A comparison of relatives of spondylitis patients with general population. Arthrtis Rheum. 1984;27:241–9.CrossRefGoogle Scholar
  9. 9.
    Feldtkeller E, Bruckel J, Kahn MA. Scientific contributions of ankylosing spondylitis patient advocacy groups. Curr Opin Rheumatol. 2000;12:239–47.CrossRefPubMedGoogle Scholar
  10. 10.
    Kay LJ, Walker DJ. Late onset spondyloarthropathy: comparison with early onset patients. Ann Rheum Dis 1997;56:572. Scholar
  11. 11.
    Caplanne D, Tubach F, Le Parc JM. Late-onset spondyloarthropathy: Clinical and biological comparison with early onset patients. Ann Rheum Dis. 1997;56:176–9.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Olivieri I, Padula A, Ciancio G, Cantini F, Salvarani C, Gonzalez-Gay MA. Late- onset HLA-B27-positive undifferentiated spondyloarthropathy: a new series of 20 patients. Arthritis Rheum. 2001;44(Suppl):S94.Google Scholar
  13. 13.
    Dubost JJ, Sauvezie B. Actualites des rhumatismes inflmmatories du sujet age. Rev Rheum Ma1 Osteoartic 1992:59(6bis):S37–42.Google Scholar
  14. 14.
    Dubost JJ, Sauvezie B. Late onset peripheral spondyloarthropathy. J Rheumatol. 1989;16:1214–17.PubMedGoogle Scholar
  15. 15.
    Olivieri N, Pipitone N, D’Angelo S, Padula A, Salvarani C. Late-onset rheumatoid arthritis and late-onset spondyloarthritis. Clin Exp Rheumatol 2009; 27(Suppl55):S139-S145.PubMedGoogle Scholar
  16. 16.
    Rudwaleit M, Van Der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of Spondyloarthritis International Society (ASAS) classification criteria for axial spondyloarthritis (prt II): validation and final selection. Annals Rheum Dis. 2009;68(6):777–783.CrossRefGoogle Scholar
  17. 17.
    Rudwaleit M. New approaches to diagnosis and classification of axial and peripheral spondyloarthritis. Curr Opin Rheumatol. 2010;22(4):375–80.CrossRefPubMedGoogle Scholar
  18. 18.
    Toussirot E. Diagnosis and management of late onset spondyloarthritis; implications of treat-to-target recommendations. Drugs Aging. 2015;32(7):515–24.CrossRefPubMedGoogle Scholar
  19. 19.
    Salvarani C, Gabriel S, Hunder GG,. Distal extremity swelling with pitting oedema in polymyalgia rheumatica. Report on nineteen cases. Arthritis Rheum. 1996;39:73–80. Salvarani C, Gabriel S, Hunder GG,. Distal extremity swelling with pitting oedema in polymyalgia rheumatica. Report on nineteen cases. Arthritis Rheum. 1996;39:73–80.Google Scholar
  20. 20.
    Salvarani C, Hunder GG. Musculoskeletal manifestations in a population –based cohort of patients with giant cell arthritis. Arthritis Rheum. 1999;42:1259–66.CrossRefPubMedGoogle Scholar
  21. 21.
    Davis JC Jr, Van der Heij de D, Braun J, Dougados M, Cush J, Clegg DU, et al. Recombinant human tumour necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized controlled trial. Arthrtis Rheum 2003;48:3230–3236.CrossRefGoogle Scholar
  22. 22.
    Bevan S. Spondyloarthropathy and wok.: A review of UK evidence.
  23. 23.
    Boonen A, Chorus A, Miedema H, van der Heijde L, Schauten H, van der Tempel, Van der Linden S. Withdrawal from labour force due to work disability in patients with ankylosing spondylitis. Ann Rheum Dis. 2001;60:1038–1039.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Nages Nagaratnam
    • 1
  • Kujan Nagaratnam
    • 1
  • Gary Cheuk
    • 2
  1. 1.The University of SydneyWestmead Clinical SchoolWestmeadAustralia
  2. 2.Rehabilitation and Aged Care ServiceBlacktown-Mt Druitt HospitalMount DruittAustralia

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