Disorders of Calcium Metabolism
Malignancy and hyperparathyroidism are the most common causes of hypercalcaemia, and malignancy accounts for about 65% in the hospital. Patients with acute hypercalcaemia usually present with gastrointestinal symptoms such as nausea, vomiting, anorexia and dehydration. Hypercalcaemia may produce ECG changes. Hypocalcaemia has a prevalence of 85% in ICU and 18% of all hospital patients. Patients with hypocalcaemia are symptomatic (tetany, seizures) or at high risk of developing complications. The chapter discusses the mechanisms underlying the disorders of calcium metabolism, their clinical manifestations and management.
KeywordsHypercalcaemia Hypocalcaemia Hyperparathyroidism Malignancy
- 2.Sexton TB,Cohen C. Hypercalcaemia and calcium metabolism in the elderly. Contemporary Geriatric Medicine. 198;3:437–453.Google Scholar
- 4.Lafferty FW. Differential diagnosis of hypercalcaemia. J Bone Miner Res. 1991;Suppl 2:S51–9.Google Scholar
- 5.Raymakers JA. Hypercalcaemia in the elderly Tijdschi Gerontol Geriatr. 1990;21(1):11–6.Google Scholar
- 7.Chia BL,Thai AC. Electrocardiographic abnormalities in combined hypercalcaemia and hypokalaemia-Case Report. Ann Acad Med Singapore. 1998;227:567–9.Google Scholar
- 8.Turhan S, Kilickap M, Kiline S. ST segment elevations mimicking acute myocardial infarction in hyperkalaemia. Health. 2005;91(8):999.Google Scholar
- 14.Shah AB, Foo YN. A retrospective study of serum calcium levels in hospital population in Malaysia. Med J Malaysia.1995;50:246–9.Google Scholar
- 16.Beach CB. Hypocalcaemia emedicine http://emedicine.midscape.com/activity/767260-overview. accessed 13.12.08.
- 17.Urbano FL. Signs of hypocalcaemia. Chvostek’s and Trousseau’s Hosp Physician. 2000;36:43–5.Google Scholar