Myeloproliferative Neoplasms

  • Nages Nagaratnam
  • Kujan Nagaratnam
  • Gary Cheuk
Reference work entry


Myeloproliferative neoplasms (MPNs) formerly known as chronic myeloproliferative disorders are clonal haemopoietic stem cell disorders characterised by excessive production of mature blood cells. The classic MPNs are polycythaemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF) (Phi-negative) and chronic myelogenous leukaemia (CML), and the central role of protein tyrosine kinases in their pathogenesis have been identified. The hallmark for diagnosis of CML is demonstrating the presence of Philadelphia (Ph) chromosome in the bone marrow cells. This review provides an overview of the myeloproliferative neoplasms, their classification and their management.


Myeloproliferative neoplasms Chronic myelogenous leukaemia Polycythaemia vera Primary myelofibrosis Essential thrombocythaemia 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Nages Nagaratnam
    • 1
  • Kujan Nagaratnam
    • 1
  • Gary Cheuk
    • 2
  1. 1.The University of SydneyWestmead Clinical SchoolWestmeadAustralia
  2. 2.Rehabilitation and Aged Care ServiceBlacktown-Mt Druitt HospitalMount DruittAustralia

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