Peptic Ulcer Disease in the Elderly
The prevalence of H. pylori increases with age , and the prevalence of H. pylori infection in patients with peptic ulcer has been reported to range from 58% to 78% in patients aged over 65 years. In the old-aged population worldwide, the incidence of peptic ulcer disease and their bleeding complications are increasing. Peptic ulcer disease is associated with hyperfunction of the G cell, increased gastric secretion and pepsinogen, impaired bicarbonate secretion and the presence of inflammatory indicators. There is strong evidence that smoking, regular use of aspirin and prolonged use of steroids are associated with the development of peptic ulcers.
KeywordsH. pylori infection Peptic ulcer disease Gastrointestinal bleeding Proton-pump inhibitor [PPI] Cigarette smoking
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