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Acinic Cell Carcinoma, Cytological Findings

  • Reference work entry
  • First Online:
Cytopathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 534 Accesses

Synonyms

Acinic cell adenocarcinoma. The term acinic cell tumor is no longer appropriate.

Definition

Acinic cell carcinoma (AcCC) is one of the three most common primary salivary malignancies with adenoid cystic carcinoma and mucoepidermoid carcinoma (Barnes et al. 2005; Ellis 2008). AcCC is an adenocarcinoma showing acinic cell differentiation with zymogen-type secretory granules. The new entity called mammary analogue of secretory carcinoma (MASC) was described in 2010 (Skálová et al. 2010).

Clinical Features

  • Incidence

    AcCC represents approximately 3% of salivary gland tumors and 8% of malignant major salivary gland tumors.

  • Age

    AcCC may occur at any age (including pediatric age), and the peak of incidence is localized between 20 and 70 years.

  • Sex

    A slight female incidence is observed.

  • Site

    The parotid gland is the predominant (80%) site and around 10% arise in the minor salivary glands.

  • Treatment

    Surgery is usually an initial treatment of AcCC.

  • Outcome

    Recurrences are possible....

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References and Further Reading

  • Barnes, L., Eveson, J. W., Reichert, P., & Sidransky, D. (Eds.). (2005). World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. Lyon: IARC Press.

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  • Bishop, J. A., Yonescu, R., Batista, D. A., Westra, W. H., & Ali, S. Z. (2013). Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathology, 121, 228–233.

    Article  CAS  PubMed  Google Scholar 

  • Ellis, G. L., & Auclair, P. L.(2008). Tumors of the salivary glands. AFIP atlas of tumor pathology. Fourth Series, Fascicle 9. Washington, DC: American Registry of Pathology, ARP Press.

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  • Gupta, S., & Sodhani, P. (1998). Sialadenosis of parotid gland: A cytomorphologic and morphometric study of four cases. Analytical and Quantitative Cytology and Histology, 20, 225–228.

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  • Klijanienko, J., & Vielh, P. (1997a). Fine-needle sample of salivary gland lesions. V: Cytology of 22 cases of acinic cell carcinoma with histologic correlation. Diagnostic Cytopathology, 17, 347–352.

    Article  CAS  PubMed  Google Scholar 

  • Klijanienko, J., & Vielh, P. (1997b). Fine-needle sampling of salivary gland lesions. II. Cytology and histology correlation of 71 cases of Warthin’s tumor (adenolymphoma). Diagnostic Cytopathology, 16, 221–225.

    Article  CAS  PubMed  Google Scholar 

  • Klijanienko, J., & Vielh, P. (1998). Fine-needle sampling of salivary gland lesions. VII. Cytology and histology correlation of five cases of epithelial-myoepithelial carcinoma. Diagnostic Cytopathology, 19, 405–409.

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  • Mrena, R., Leivo, I., Passador-Santos, F., Hagström, J., & Mäkitie, A. A. (2008). Histopathological findings in parotid gland metastases from renal cell carcinoma. European Archives of Oto-Rhino-Laryngology, 265, 1005–1009.

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  • Pisharodi, L. (2013). Mammary analog secretory carcinoma of salivary gland: Cytologic diagnosis and differential diagnosis of an unreported entity. Diagnostic Cytopathology, 41, 239–241.

    Article  PubMed  Google Scholar 

  • Skálová, A., Vanecek, T., Sima, R., Laco, J., Weinreb, I., Perez-Ordonez, B., Starek, I., Geierova, M., Simpson, R. H., Passador-Santos, F., Ryska, A., Leivo, I., Kinkor, Z., & Michal, M. (2010). Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity. The American Journal of Surgical Pathology, 34, 599–608.

    PubMed  Google Scholar 

  • Weinreb, I. (2013). Translocation-associated salivary gland tumors: A review and update. Advances in Anatomic Pathology, 20, 367–377.

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Author information

Authors and Affiliations

  1. Institut Curie, 26, rue d’Ulm, 75005, Paris, France

    Jerzy Klijanienko

  2. Department of Biopathology, Gustave Roussy Cancer Campus, 114, rue Edouard Vaillant, 94805, Villejuif, France

    Philippe Vielh

Authors
  1. Jerzy Klijanienko
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  2. Philippe Vielh
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Corresponding author

Correspondence to Jerzy Klijanienko .

Editor information

Editors and Affiliations

  1. Laboratoire national de santé, Luxembourg City, Luxembourg

    Fernando Schmitt

  2. Medical Faculty of Porto University and IPATIMUP, Porto, Portugal

    Fernando Schmitt

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Klijanienko, J., Vielh, P. (2017). Acinic Cell Carcinoma, Cytological Findings. In: Schmitt, F. (eds) Cytopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-33286-4_808

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  • DOI: https://doi.org/10.1007/978-3-319-33286-4_808

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33285-7

  • Online ISBN: 978-3-319-33286-4

  • eBook Packages: MedicineReference Module Medicine

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