Abstract
Between the dermis (syn: cutis) and the underlying bones, muscles, or fasciae lies a tissue of uneven thickness according to body sites and individuals, called subcutaneous tissue or subcutis (syn: hypodermis). The term “subcutaneous fascia” is sometimes used as a synonym for subcutaneous tissue, although this definition is the subject of current debate as outlined below. From an anatomical and physiological viewpoint, subcutaneous tissue contains two components which, although intricate, have different functions: the interstitial tissue and the adipose tissue.
Keywords
- subcutaneous tissue
- adipose tissue
- subcutis connective tissue
Pierre Agache: deceased.
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Abu-Hijleh MF, Roshier AL, Al-Shboul Q, Dharap AS, Harris PF. The membranous layer of superficial fascia: evidence for its widespread distribution in the body. Surg Radiol Anat. 2006;28(6):606–19.
Benjamin M. The fascia of the limbs and back – a review. J Anat. 2009;214(1):1–18.
Black MM, Cunliffe WJ. Subcutaneous fat. In: Champion RH, Burton JL, Burns DA, Breathnagh SM, editors. Textbook of dermatology. 6th ed. Oxford: Blackwell; 1998. p. 2403–7.
Brace RA, Guyton AC. Interstitial fluid pressure: capsule, free fluid, gel fluid, and gel absorption pressure in subcutaneous tissue. Microvasc Res. 1979;18:217–28.
Cao H. Adipocytokines in obesity and metabolic disease. J Endocrinol. 2014;220(2):T47–59. doi:10.1530/JOE-13-0339. Print 2014 Feb.
Corey SM, Vizzard MA, Badger GJ, Langevin HM. Sensory innervation of the nonspecialized connective tissues in the low back of the rat. Cells Tissues Organs. 2011;194(6):521–30.
Exton-Smith AN. Pressure problems in the elderly. In: Barbenel JC, Forbes CD, Lowe GDO, editors. Pressure sores. Bath: The Pitman Press; 1983. p. 81–90.
Fried SK, Kral JG. Sex differences in regional distribution of fat cell size and lipoprotein lipase activity in morbidly obese patients. Int J Obes. 1987;11:129–40.
Friedman JM. Obesity in the new millennium. Nature. 2000;404:632–4.
Hoheisel U, Taguchi T, Treede RD, Mense S. Nociceptive input from the rat thoracolumbar fascia to lumbar dorsal horn neurons. Eur J Pain. 2011;15(8):810–5.
Houdas Y, Guieu JD. Physiologie humaine: la fonction thermique. Villeurbanne: Simep-editions; 1977.
Iatridis JC, Wu J, Yandow JA, Langevin HM. Subcutaneous tissue mechanical behavior is linear and viscoelastic under uniaxial tension. Connect Tissue Res. 2003;44(5):208–17.
Jungermann K, Barth CA. Energy metabolism and nutrition. In: Greger R, Windhorst U, editors. Comprehensive human physiology, vol. 2. Berlin: Springer; 1996. p. 1425–57.
Lancerotto L, Stecco C, Macchi V, Porzionato A, Stecco A, De Caro R. Layers of the abdominal wall: anatomical investigation of subcutaneous tissue and superficial fascia. Surg Radiol Anat. 2011;33(10):835–42.
Langevin HM, Bouffard NA, Badger GJ, Iatridis JC, Howe AK. Dynamic fibroblast cytoskeletal response to subcutaneous tissue stretch ex vivo and in vivo. Am J Physiol Cell Physiol. 2005;288(3):C747–56.
Langevin HM, Bouffard NA, Fox JR, Palmer BM, Wu J, Iatridis JC, Barnes WD, Badger GJ, Howe AK. Fibroblast cytoskeletal remodeling contributes to connective tissue tension. J Cell Physiol. 2011;226(5):1166–75.
Langevin HM, Nedergaard M, Hhowe AK. Cellular control of connective tissue matrix tension. J Cell Biochem. 2013a;114:1714–9.
Langevin HM, Fujita T, Bouffard NA, Takano T, Koptiuch C, Badger GJ, Nedergaard M. Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling. J Cell Physiol. 2013b;228(9):1922–6.
Lee YH, Mottillo EP, Granneman JG. Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta. 2014;1842(3):358–69.
Lever WF, Schaumburg-Lever G, editors. Histopathology of the skin. 6th ed. Philadelphia: Lippincott; 1983. p. 655.
Levine JA, Ray A, Jensen MD. Relation between chubby cheeks and visceral fat. N Engl J Med. 1998;339:1946–7.
Mauriege P, Galitzky J, Berlan M, Lafontan M. Heterogeneous distribution of bet and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur J Clin Invest. 1987;17:156–65.
Mauriege P, De Pergola G, Berlan M, Lafontan M. Human fat cell beta-adrenergic receptors: beta-agonist-dependent lipolytic responses and characterization of beta-adrenergic binding sites on human fat cell membranes with highly selective beta 1-antagonists. J Lipid Res. 1988;29:587–601.
Patel P, Abate N. Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance. J Obes. 2013;2013:489187.
Peirce V, Carobbio S, Vidal-Puig A. The different shades of fat. Nature. 2014;510(7503):76–83.
Rebuffé-Scrive M. Regional adipose tissue metabolism in women during and after reproductive life and in men. In: Berry EM, Blondheim SH, Eliahou HE, Shafrir E, editors. Recent advances in obesity research: proc. 5th international congress on obesity, 14–19 September 1986. Jerusalem: Westport, Food & Nutrition Press; 1987. p. 82–91.
Rebuffé-Scrive M. Stéroid hormones and distribution of adipose tissue. Acta Med Scand. 1988;723(Suppl):143–6.
Rebuffé-Scrive M, Enk L, Crona N, Lonnroth P, Abrahamssor L, Smith U, Bjorntop P. Fat cell metabolism in different regions in women: effect of menstrual cycle, pregnancy and lactation. J Clin Invest. 1985;75:1973–6.
Reed RK, Rubin K. Transcapillary exchange: role and importance of the interstitial fluid pressure and the extracellular matrix. Cardiovasc Res. 2010;87(2):211–7.
Renkin EM, Crone C. Microcirculation and capillary exchange. In: Greger R, Windhorst U, editors. Comprehensive human physiology. From cellular mechanisms to integration, vol. 2. Berlin: Springer; 1996. p. 1965–79.
Richelsen B. Increased alpha 2- but similar beta-adrenergic receptor activities in subcutaneous gluteal adipocytes from females compared with males. Eur J Clin Invest. 1986;16:302–9.
Scott JE. Physiological function and chemical composition of pericellular proteoglycan (an evolutionary view). Proc R Soc Lond Ser B. 1975;271:235–42.
Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z. A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation. Nat Cell Biol. 2001;3:267–75.
Sjostrom L, Björntorp P, Vrana J. Microscopic fat cell size measurements on frozen-cut adipose tissue in comparison with automatic determinations of osmium fixed fat cells. J Lipid Res. 1971;12:521.
Sudan N, Payan H. Ultrastructure du tissu adipeux blanc. Vie Med (Paris). 1974;37:4533–44.
Tesarz J, Hoheisel U, Wiedenhöfer B, Mense S. Sensory innervation of the thoracolumbar fascia in rats and humans. Neuroscience. 2011;194:302–8.
Vague J, Rubin P, Jubelin J, Vague P. Topographie des adipocytes chez l’homme. Vie Med (Paris). 1974;37:4547–58.
Vague J, Meignen JM, Negrin JF, Thomas M, Tramoni M, Jubelin J. Androgènes, oestrogènes et cortisol dans la physiopathologie du tissu adipeux. Sem Hôp Paris. 1984;60:1465–76.
Wahner HW, Fogelman I. Total body mineral and body composition by absorbtiometry. In Wahner HW, Fogelman I, (eds). The evaluation of osteoporosis: Dual energy X-ray absortiometry in clinical practice. Martin-Dunitz, London, 1994, 196–218.
Wiig H, Rubin K, Reed RK. New and active role of the interstitium in control of interstitial fluid pressure: potential therapeutic consequences. Acta Anaesthesiol Scand. 2003;47(2):111–21. Review.
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Langevin, H.M., Agache, P. (2017). Subcutaneous Tissue Histophysiology. In: Humbert, P., Fanian, F., Maibach, H., Agache, P. (eds) Agache's Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-32383-1_88
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DOI: https://doi.org/10.1007/978-3-319-32383-1_88
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