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In Vivo Magnetic Resonance Imaging of the Skin

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Agache's Measuring the Skin

Abstract

MRI of the skin is a recent imaging technique that has several advantages over other noninvasive imaging techniques of the skin. MRI is a non-radiating imaging modality that is also reproducible and non-operator dependent. Because of its wider field of view than ultrasound, its spatial resolution under 100 μm, and its excellent contrast, MRI allows high-quality imaging of every skin layers. In addition to morphological analysis, it is also able to study some physical and biochemical properties of the skin.

The objectives of this article are to remind technical aspect of MRI of the skin, to describe the normal features of the skin, to discuss challenges in diagnosis of skin disorders, and to present the principal applications of MRI for the in vivo characterization of its biochemical properties.

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Abbreviations

BCC:

Basal cell carcinoma

FIESTA:

Fast imaging employing steady-state acquisition

MRI:

Magnetic resonance imaging

SCC:

Squamous cell carcinoma

T1w :

T1 weighted

T2W :

T2 weighted

US:

Ultrasound

References

  • Aubry S, Leclerc O, Tremblay L, Rizcallah E, Croteau F, Orfali C, et al. 7-tesla MR imaging of non-melanoma skin cancer samples: correlation with histopathology. Skin Res Technol. 2012;18(4):413–20.

    Google Scholar 

  • Aubry S, Casile C, Humbert P, Jehl J, Vidal C, Kastler B. Feasibility study of 3-T MR imaging of the skin. Eur Radiol. 2009;19(7):1595–603.

    Article  PubMed  Google Scholar 

  • Baek HJ, Lee SJ, Cho KH, Choo HJ, Lee SM, Lee YH, et al. Subungual tumors: clinicopathologic correlation with US and MR imaging findings. Radiographics. 2010; 30(6):1621–36.

    Google Scholar 

  • Barral JK, Bangerter NK, Hu BS, Nishimura DG. In vivo high-resolution magnetic resonance skin imaging at 1.5 T and 3 T. Magn Reson Med. 2010;63(3):790–6.

    Google Scholar 

  • Bittoun J, Saint-Jalmes H, Querleux BG, Darrasse L, Jolivet O, Idy-Peretti I, et al. In vivo high-resolution MR imaging of the skin in a whole-body system at 1.5 T. Radiology. 1990;176(2):457–60.

    Article  CAS  PubMed  Google Scholar 

  • Bittoun J, Querleux B, Darrasse L. Advances in MR imaging of the skin. NMR Biomed. 2006;19(7):723–30.

    Article  PubMed  Google Scholar 

  • Chen Y, Richards TL, Izenberg S, Golden RN, Williams DL, Nelson JA, et al. In vivo phosphorus NMR spectroscopy of skin using a crossover surface coil. Magn Reson Med. 1992;23(1):46–54.

    Article  CAS  PubMed  Google Scholar 

  • Collier SW, Sardon S, Ruiz-Cabello J, Johnson WA, Cohen JS, Schwartz SL. Measurement of pharmacodynamic effects of dexamethasone on epidermis by phosphorus nuclear magnetic resonance spectroscopy in vitro. J Pharm Sci. 1994;83(9):1339–44.

    Article  CAS  PubMed  Google Scholar 

  • Corcuff P, Bertrand C, Leveque JL. Morphometry of human epidermis in vivo by real-time confocal microscopy. Arch Dermatol Res. 1993;285(8):475–81.

    Article  CAS  PubMed  Google Scholar 

  • Denis A, Loustau O, Chiavassa-Gandois H, Vial J, Lalande Champetier de Ribes C, Railhac JJ, et al. High resolution MR imaging of the skin: normal imaging features. J Radiol. 2008;89(7–8 Pt 1):873–9.

    Article  CAS  PubMed  Google Scholar 

  • Drape JL, Wolfram-Gabel W, Idy-Peretti I, Baran R, Goettmann S, Sick H, et al. The lunula: a magnetic resonance imagining approach to the subnail matrix area. J Invest Dermatol. 1996;106(5):1081–5.

    Article  CAS  PubMed  Google Scholar 

  • Edwards C, Al-Aboosi MM, Marks R. The use of A-scan ultrasound in the assessment of small skin tumours. Br J Dermatol. 1989;121(3):297–304.

    Article  CAS  PubMed  Google Scholar 

  • Fornage BD, McGavran MH, Duvic M, Waldron CA. Imaging of the skin with 20-MHz US. Radiology. 1993;189(1):69–76.

    Article  CAS  PubMed  Google Scholar 

  • Goettmann S, Drape JL, Idy-Peretti I, Bittoun J, Thelen P, Arrive L, et al. Magnetic resonance imaging: a new tool in the diagnosis of tumours of the nail apparatus. Br J Dermatol. 1994;130(6):701–10.

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez S, Duarte I. Benign fibrous histiocytoma of the skin. A morphologic study of 290 cases. Pathol Res Pract. 1982;174(4):379–91.

    Article  CAS  PubMed  Google Scholar 

  • Gufler H, Franke FE, Rau WS. High-resolution MRI of basal cell carcinomas of the face using a microscopy coil. AJR Am J Roentgenol. 2007;188(5):W480–4.

    Article  PubMed  Google Scholar 

  • Harland CC, Bamber JC, Gusterson BA, Mortimer PS. High frequency, high resolution B-scan ultrasound in the assessment of skin tumours. Br J Dermatol. 1993;128(5):525–32.

    Article  CAS  PubMed  Google Scholar 

  • Hawnaur JM, Dobson MJ, Zhu XP, Watson Y. Skin: MR imaging findings at middle field strength. Radiology. 1996;201(3):868–72.

    Article  CAS  PubMed  Google Scholar 

  • Hayashi K, Koga H, Uhara H, Saida T. High-frequency 30-MHz sonography in preoperative assessment of tumor thickness of primary melanoma: usefulness in determination of surgical margin and indication for sentinel lymph node biopsy. Int J Clin Oncol. 2009;14(5):426–30.

    Article  PubMed  Google Scholar 

  • Hyde JS, Jesmanowicz A, Kneeland JB. Surface coil for MR imaging of the skin. Magn Reson Med. 1987;5(5):456–61.

    Article  CAS  PubMed  Google Scholar 

  • James W. Andrews’ diseases of the skin: clinical dermatology. 10th ed. Philadelphia: Saunders Elsevier; 2006.

    Google Scholar 

  • Kim YH, Orenberg EK, Faull KF, Wade-Jardetzky NG, Jardetzky O. 1H NMR spectroscopy: an approach to evaluation of diseased skin in vivo. J Invest Dermatol. 1989;92(2):210–6.

    Article  CAS  PubMed  Google Scholar 

  • Kim JH, Kim JY, Chun KA, Jee WH, Sung MS. MR imaging manifestations of skin tumors. Eur Radiol. 2008;18(11):2652–61.

    Article  PubMed  Google Scholar 

  • Kinsey ST, Moerland TS, McFadden L, Locke BR. Spatial resolution of transdermal water mobility using NMR microscopy. Magn Reson Imaging. 1997;15(8):939–47.

    Article  CAS  PubMed  Google Scholar 

  • Kransdorf MJ. Benign fibrous and fibrohistiocytic tumors. In: Kransdorf MJ et al., editors. Imaging of soft tissue tumors. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 195–6.

    Google Scholar 

  • Kransdorf MJ, Meis-Kindblom JM. Dermatofibrosarcoma protuberans: radiologic appearance. AJR Am J Roentgenol. 1994;163(2):391–4.

    Article  CAS  PubMed  Google Scholar 

  • Kwon Song H, Wehrli FW, Ma J. In vivo MR microscopy of the human skin. Magn Reson Med. 1997;37:185–91.

    Article  Google Scholar 

  • Lassau N, Chami L, Peronneau P. Imaging of melanoma: accuracy of ultrasonography before and after contrast injection for diagnostic and early evaluation of treatments. Bull Cancer. 2007;94(1):93–8.

    PubMed  Google Scholar 

  • Calzolari L, Kastler A, Mac-Mary S, Humbert P, Kastler B, Aubry S.3T-MRI analysis of epidermis and dermis moisturizing using the T2-mapping sequence. Skin Res Technol. 2013 May;19(2):152-4

    Google Scholar 

  • Lee D, Kim J, Lee H. Investigation of biochemical changes in skin layers by NMR microscopy. Skin Res Technol. 1998;4:142–6.

    Article  CAS  PubMed  Google Scholar 

  • Marghoob AA, Swindle LD, Moricz CZ, Sanchez Negron FA, Slue B, Halpern AC, et al. Instruments and new technologies for the in vivo diagnosis of melanoma. J Am Acad Dermatol. 2003;49(5):777–97; quiz 98–9.

    Article  PubMed  Google Scholar 

  • Masters BR, Gonnord G, Corcuff P. Three-dimensional microscopic biopsy of in vivo human skin: a new technique based on a flexible confocal microscope. J Microsc. 1997;185(Pt 3):329–38.

    Article  CAS  PubMed  Google Scholar 

  • McDonald PJ, Akhmerov A, Backhouse LJ, Pitts S. Magnetic resonance profiling of human skin in vivo using GARField magnets. J Pharm Sci. 2005;94(8):1850–60.

    Article  CAS  PubMed  Google Scholar 

  • Miller S. The National Comprehensive Cancer Network (NCCN) guidelines of care for nonmelanoma skin cancers. Dermatol Surg. 2000;26:289–92.

    Article  CAS  PubMed  Google Scholar 

  • Mirrashed F, Sharp JC. In vivo quantitative analysis of the effect of hydration (immersion and Vaseline treatment) in skin layers using high-resolution MRI and magnetisation transfer contrast. Skin Res Technol. 2004a;10(1):14–22.

    Article  PubMed  Google Scholar 

  • Mirrashed F, Sharp JC. In vivo morphological characterisation of skin by MRI micro-imaging methods. Skin Res Technol. 2004b;10(3):149–60.

    Article  PubMed  Google Scholar 

  • Mordon S. les techniques photoniques de l’UV aux IR. [cited 17/12/07]; Available from: e2phyin2p3fr/2002/actes/mordondoc. 2002.

    Google Scholar 

  • Ono I, Kaneko F. Magnetic resonance imaging for diagnosing skin tumors. Clin Dermatol. 1995;13(4):393–9.

    Article  CAS  PubMed  Google Scholar 

  • Pennasilico GM, Arcuri PP, Laschena F, Potenza C, Ruatti P, Bono R, et al. Magnetic resonance imaging in the diagnosis of melanoma: in vivo preliminary studies with dynamic contrast-enhanced subtraction. Melanoma Res. 2002;12(4):365–71.

    Article  CAS  PubMed  Google Scholar 

  • Psaty EL, Halpern AC. Current and emerging technologies in melanoma diagnosis: the state of the art. Clin Dermatol. 2009;27(1):35–45.

    Article  PubMed  Google Scholar 

  • Querleux B. Caractérisation de la peau humaine in vivo par imagerie et spectroscopie par résonance magnétique. In: Humbert P, Zaouani H, editors. Actualités en Ingénierie Cutanée. Paris: ESKA; 2001. p. 11–9.

    Google Scholar 

  • Querleux B. Magnetic resonance imaging and spectroscopy of skin and subcutis. J Cosmet Dermatol. 2004;3(3):156–61.

    Article  PubMed  Google Scholar 

  • Querleux B, Leveque JL, de Rigal J. In vivo cross-sectional ultrasonic imaging of human skin. Dermatologica. 1988;177(6):332–7.

    Article  CAS  PubMed  Google Scholar 

  • Querleux B, Richard S, Bittoun J, Jolivet O, Idy-Peretti I, Bazin R, et al. In vivo hydration profile in skin layers by high-resolution magnetic resonance imaging. Skin Pharmacol. 1994;7(4):210–6.

    Article  CAS  PubMed  Google Scholar 

  • Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol. 1995;104(6):946–52.

    Article  CAS  PubMed  Google Scholar 

  • Richard S, Querleux B, Bittoun J, Idy-Peretti I, Jolivet O, Cermakova E, et al. In vivo proton relaxation times analysis of the skin layers by magnetic resonance imaging. J Invest Dermatol. 1991;97(1):120–5.

    Article  CAS  PubMed  Google Scholar 

  • Richard S, Querleux B, Bittoun J, Jolivet O, Idy-Peretti I, de Lacharriere O, et al. Characterization of the skin in vivo by high resolution magnetic resonance imaging: water behavior and age-related effects. J Invest Dermatol. 1993;100(5):705–9.

    Article  CAS  PubMed  Google Scholar 

  • Sandby-Moller J, Wulf HC. Ultrasonographic subepidermal low-echogenic band, dependence of age and body site. Skin Res Technol. 2004;10(1):57–63.

    Article  PubMed  Google Scholar 

  • Sans N, Faruch M, Chiavassa-Gandois H, de Ribes CL, Paul C, Railhac JJ. High-resolution magnetic resonance imaging in study of the skin: normal patterns. Eur J Radiol. 2011;80(2):e176–81.

    Google Scholar 

  • Smith L, Macneil S. State of the art in non-invasive imaging of cutaneous melanoma. Skin Res Technol. 2011;17(3):257-69.

    Google Scholar 

  • Stefanowska J, Zakowiecki D, Cal K. Magnetic resonance imaging of the skin. J Eur Acad Dermatol Venereol. 2010; 24(8):875–80.

    Google Scholar 

  • Takahashi M, Kohda H. Diagnostic utility of magnetic resonance imaging in malignant melanoma. J Am Acad Dermatol. 1992;27(1):51–4.

    Article  CAS  PubMed  Google Scholar 

  • Torreggiani WC, Al-Ismail K, Munk PL, Nicolaou S, O’Connell JX, Knowling MA. Dermatofibrosarcoma protuberans: MR imaging features. AJR Am J Roentgenol. 2002;178(4):989–93.

    Article  PubMed  Google Scholar 

  • Vilana R, Puig S, Sanchez M, Squarcia M, Lopez A, Castel T, et al. Preoperative assessment of cutaneous melanoma thickness using 10-MHz sonography. AJR Am J Roentgenol. 2009;193(3):639–43.

    Article  PubMed  Google Scholar 

  • Weis J, Ericsson A, Astrom G, Szomolanyi P, Hemmingsson A. High-resolution spectroscopic imaging of the human skin. Magn Reson Imaging. 2001;19(2):275–8.

    Article  CAS  PubMed  Google Scholar 

  • Welzel J. Optical coherence tomography. In: Agache P, Humbert P, editors. Measuring the skin. Berlin: Springer; 2004. p. 222–9.

    Chapter  Google Scholar 

  • Zemtsov A, Lorig R, Bergfield WF, Bailin PL, Ng TC. Magnetic resonance imaging of cutaneous melanocytic lesions. J Dermatol Surg Oncol. 1989;15(8):854–8.

    Article  CAS  PubMed  Google Scholar 

  • Zemtsov A, Dixon L, Cameron G. Human in vivo phosphorus 31 magnetic resonance spectroscopy of psoriasis. A noninvasive tool to monitor response to treatment and to study pathophysiology of the disease. J Am Acad Dermatol. 1994;30(6):959–65.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Sébastien Aubry .

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Kechidi, R., Aubry, S. (2017). In Vivo Magnetic Resonance Imaging of the Skin. In: Humbert, P., Fanian, F., Maibach, H., Agache, P. (eds) Agache's Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-32383-1_51

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  • DOI: https://doi.org/10.1007/978-3-319-32383-1_51

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