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Gene Expression and Genetic Evaluation of the Skin

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Agache's Measuring the Skin

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Abstract

In this chapter, our purpose is to provide some clues on what can or cannot be expected from gene expression and genetic testing to investigate skin physiopathology using DNA microarrays. The use of these technologies has dramatically increased during the past years, and several studies have been performed for various dermatological diseases, such as malignant melanoma, psoriasis, and lupus erythematosus (reviewed in Kunz et al. (Exp Dermatol 13(10):593–606, 2004)). Identification of key target genes and pathways involved in such diseases provides enormous perspectives for dermatologists. The first section of this chapter will describe the main features of the available DNA microarray technologies and methodologies to be mastered in order to get meaningful data. In the second section, we choose to show how gene expression profiling can contribute to increase our basic knowledge on psoriasis as a case study as well as to identify diagnostic/prognostic markers. In the last section, the impact of combined discoveries issued from the analyses of gene expression and genetic testing based on single nucleotide polymorphism (SNP) in dermatology will be discussed. We hope that the present chapter will provide the basic understanding of these technologies to dermatologists, helping them to deal with the complexity of what is called functional genomics.

If our brains were simple enough for us to understand them, we’d be so simple that we couldn’t. (Ian Stewart, The Collapse of Chaos: Discovering Simplicity in a Complex World)

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Authors and Affiliations

  1. Faculté de Médecine Secteur Nord, UMR 7259 (NICN) CNRS – Aix-Marseille Université, CS80011, 51 Bd Pierre Dramard, 13344, CEDEX 15, Marseille, France

    Philippe Benech

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  1. Philippe Benech
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Correspondence to Philippe Benech .

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Editors and Affiliations

  1. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Philippe Humbert

  2. Center for Study and Research on the Integuments, Department of Dermatology, University Hospital of Besançon, Besançon, France

    Ferial Fanian

  3. Department of Dermatology, School of Medicine, University of California, San Francisco, California, USA

    Howard I. Maibach

  4. Department of Dermatology, University Hospital of Besançon, Besançon, France

    Pierre Agache

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Benech, P. (2017). Gene Expression and Genetic Evaluation of the Skin. In: Humbert, P., Fanian, F., Maibach, H., Agache, P. (eds) Agache's Measuring the Skin. Springer, Cham. https://doi.org/10.1007/978-3-319-32383-1_126

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  • DOI: https://doi.org/10.1007/978-3-319-32383-1_126

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-32381-7

  • Online ISBN: 978-3-319-32383-1

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