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Palliative Care in Heart Failure

  • James M. Beattie
  • Jillian P. Riley
Living reference work entry

Abstract

Heart failure is a life limiting cardiovascular condition, frequently encountered in the increasingly aged population. People affected endure a symptomatic burden and mortality risk at least equivalent to those associated with common cancers. However, the clinical scenario is usually more complicated in that heart failure tends to occur in multimorbid older individuals who exhibit an unpredictable disease trajectory. In most patients, cardiac function tends to decline inexorably, with a mortality of about 50% in the 5 years following diagnosis. An ever more complex evidence-based therapy, which likely materially benefits less than half of those with this clinical diagnosis, involves polypharmacy, implanted cardiac devices, and consideration for surgical intervention including cardiac transplantation. Acknowledging its prognostic ambiguity, the capricious nature of the heart failure state, and the relatively onerous treatment protocol may undermine care coordination, patient autonomy, and ultimately conflict with patients’ and families’ preferences for care along a progressively declining clinical course to the end of life. This chapter describes the challenges and opportunities in providing palliative care to this burgeoning clinical population.

References

  1. Aaronson KD, Schwartz JS, Chen TM, Wong KL, Goin JE, Mancini DM. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation. 1997;95(12):2660–7.PubMedCrossRefGoogle Scholar
  2. Adams J, Kuchibhatla M, Christopher EJ, Alexander JD, Clary GL, Cuffe MS, et al. Association of depression and survival in patients with chronic heart failure over 12 years. Psychosomatics. 2012;53(4):339–46.  https://doi.org/10.1016/j.psym.2011.12.002.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Agård A, Löfmark R, Edvardsson N, Ekman I. Views of patients with heart failure about their role in the decision to start implantable cardioverter defibrillator treatment: prescription rather than participation. J Med Ethics. 2007;33(9):514–8.  https://doi.org/10.1136/jme.2006.017723.PubMedPubMedCentralCrossRefGoogle Scholar
  4. Alagiakrishnan K, Mah D, Ahmed A, Ezekowitz J. Cognitive decline in heart failure. Heart Fail Rev. 2016;21(6):661–73.  https://doi.org/10.1007/s10741-016-9568-1.PubMedCrossRefGoogle Scholar
  5. Aliti GB, Rabelo ER, Clausell N, Rohde LE, Biolo A, Beck-da-Silva L. Aggressive fluid and sodium restriction in acute decompensated heart failure: a randomized clinical trial. JAMA Intern Med. 2013;173(12):1058–64.  https://doi.org/10.1001/jamainternmed.2013.552.PubMedCrossRefGoogle Scholar
  6. Allen LA, Yager JE, Funk MJ, Levy WC, Tulsky JA, Bowers MT, et al. Discordance between patient-predicted and model predicted life expectancy among ambulatory patients with heart failure. JAMA. 2008;299:2533–42.  https://doi.org/10.1001/jama.299.21.2533.PubMedPubMedCentralCrossRefGoogle Scholar
  7. Allen LA, Stevenson LW, Grady KL, Goldstein NE, Matlock DD, Arnold RM, American Heart Association; Council on Quality of Care and Outcomes Research, Council on Cardiovascular Nursing; Council on Clinical Cardiology, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular Surgery and Anesthesia, et al. Decision making in advanced heart failure: a scientific statement from the American Heart Association. Circulation. 2012;125(15):1928–52.  https://doi.org/10.1161/CIR.0b013e31824f2173.PubMedPubMedCentralCrossRefGoogle Scholar
  8. Allen LA, Matlock DD, Shetterly SM, Xu S, Levy WC, Portalupi LB, et al. Use of risk models to predict death in the next year among individual ambulatory patients with heart failure. JAMA Cardiol. 2017;2(4):435–41.  https://doi.org/10.1001/jamacardio.2016.5036.PubMedCrossRefGoogle Scholar
  9. Allida SM, Inglis SC, Davidson PM, Lal S, Hayward CS, Newton PJ. Thirst in chronic heart failure: a review. Clin Nurs. 2015;24(7–8):916–26.  https://doi.org/10.1111/jocn.12732.CrossRefGoogle Scholar
  10. Alonso W, Hupcey JE, Kitko L. Caregivers’ perceptions of illness severity and end of life service utilization in advanced heart failure. Heart Lung. 2017;46:35–9.  https://doi.org/10.1016/j.hrtlng.2016.09.001.PubMedCrossRefGoogle Scholar
  11. Ampadu J, Morley JE. Heart failure and cognitive dysfunction. Int J Cardiol. 2015;178:12–23.  https://doi.org/10.1016/j.ijcard.2014.10.087.PubMedCrossRefGoogle Scholar
  12. Atwater BD, Daubert JP. Implantable cardioverter defibrillators: risks accompany the life-saving benefits. Heart. 2012;98(10):764–72.  https://doi.org/10.1136/heartjnl-2012-301853.PubMedCrossRefGoogle Scholar
  13. Banner NR, Bonser RS, Clark AL, Clark S, Cowburn PJ, Gardner RS, et al. UK guidelines for referral and assessment of adults for heart transplantation. Heart. 2011;97(18):1520–7.  https://doi.org/10.1136/heartjnl-2011-300048.PubMedCrossRefGoogle Scholar
  14. Barclay S, Momen N, Case-Upton S, Kuhn I, Smith E. End-of-life care conversations with heart failure patients: a systematic literature review and narrative synthesis. Br J Gen Pract. 2011;61(582):e49–62.  https://doi.org/10.3399/bjgp11X549018.PubMedCrossRefGoogle Scholar
  15. Barra S, Providencia R, Paiva L, Heck P, Agarwal S. Implantable cardioverter-defibrillators in the elderly: rationale and specific age-related considerations. Europace. 2015;17:174–86.  https://doi.org/10.1093/europace/euu296.PubMedCrossRefGoogle Scholar
  16. Bayoumi E, Sheikh F, Groninger H. Palliative care in cardiac transplantation: an evolving model. Heart Fail Rev. 2017;22(5):605–10.  https://doi.org/10.1007/s10741-017-9613-8.PubMedCrossRefGoogle Scholar
  17. Beattie JM, Johnson MJ. Subcutaneous furosemide in advanced heart failure: has clinical practice run ahead of the evidence base? BMJ Support Palliat Care. 2012;2(1):5–6.  https://doi.org/10.1136/bmjspcare-2011-000199.PubMedCrossRefGoogle Scholar
  18. Beattie JM, Butler J, MacCallum A, Fuller A, Johnson MJ. A national survey of the management of implantable cardioverter defibrillators in specialist palliative care settings. BMJ Support Palliat Care. 2012;2(Suppl 1):A101.CrossRefGoogle Scholar
  19. Becnel MF, Ventura HO, Krim SR. Changing our approach to stage D heart failure. Prog Cardiovasc Dis. 2017;60(2):205–14.  https://doi.org/10.1016/j.pcad.2017.08.003.PubMedCrossRefGoogle Scholar
  20. Bekelman DB, Rumsfeld JS, Havranek EP, Yamashita TE, Hutt E, Gottlieb SH, et al. Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients. J Gen Intern Med. 2009;24:592–8.  https://doi.org/10.1007/s11606-009-0931-y.PubMedPubMedCentralCrossRefGoogle Scholar
  21. Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, American Heart Association Statistics Committee and Stroke Statistics Subcommittee, et al. Heart disease and stroke Statistics-2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146–603.  https://doi.org/10.1161/CIR.0000000000000485.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Berlacher K, Arnold RM, Reitschuler-Cross E, Teuteberg J, Teuteberg W. The impact of communication skills training on cardiology fellows’ and attending physicians’ perceived comfort with difficult conversations. J Palliat Med. 2017;20:767–9.  https://doi.org/10.1089/jpm.2016.0509.PubMedCrossRefGoogle Scholar
  23. Bevan J, Pen L-A, Mitchell ARJ. Permanent catheter drainage system for palliation of diuretic-resistant ascites. ESC Heart Fail. 2016;3:60–2.  https://doi.org/10.1002/ehf2.12074.CrossRefGoogle Scholar
  24. Blinderman CD, Homel P, Billings A, Porenoy RK, Tennstedt SL. Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manag. 2008;35:594–603.  https://doi.org/10.1016/j.jpainsymman.2007.06.007.CrossRefGoogle Scholar
  25. Borlaug BA, Paulus WJ. Heart failure with preserved ejection fraction: pathophysiology, diagnosis and treatment. Eur Heart J. 2011;32:670–9.  https://doi.org/10.1093/eurheartj/ehq426.PubMedCrossRefGoogle Scholar
  26. Boudoulas KD, Triposkiadis F, Parissis J, Butler J, Boudoulas H. The cardio-renal interrelationship. Prog Cardiovasc Dis. 2017;59(6):636–48.  https://doi.org/10.1016/j.pcad.2016.12.003.PubMedCrossRefGoogle Scholar
  27. Brännström M, Boman K. Effects of person-centred and integrated chronic heart failure and palliative home care. PREFER: a randomized controlled study. Eur J Heart Fail. 2014;16:1142–51.  https://doi.org/10.1002/ejhf.151.PubMedCrossRefGoogle Scholar
  28. Braun LT, Grady KL, Kutner JS, Adler E, Berlinger N, Boss R, American Heart Association Advocacy Coordinating Committee, et al. Palliative care and cardiovascular disease and stroke: a policy statement from the American Heart Association/American Stroke Association. Circulation. 2016;134(11):e198–225.  https://doi.org/10.1161/CIR.0000000000000438.PubMedCrossRefGoogle Scholar
  29. Braunwald E. The war against heart failure: the lancet lecture. Lancet. 2015;385(9970):812–24.  https://doi.org/10.1016/S0140-6736(14)61889-4.PubMedCrossRefGoogle Scholar
  30. Brunner-La Rocca HP, Rickenbacher P, Muzzarelli S, Schindler R, Maeder MT, Jeker U, TIME-CHF Investigators, et al. End-of-life preferences of elderly patients with chronic heart failure. Eur Heart J. 2012;33(6):752–9.  https://doi.org/10.1093/eurheartj/ehr404.PubMedCrossRefGoogle Scholar
  31. Campbell RT, Jackson CE, Wright A, Gardner RS, Ford I, Davidson PM, et al. Palliative care needs in patients hospitalized with heart failure (PCHF) study: rationale and design. ESC Heart Fail. 2015;2:25–36.  https://doi.org/10.1002/ehf2.12027.PubMedCentralCrossRefGoogle Scholar
  32. Cannon JA, Moffitt P, Perez-Moreno AC, Walters MR, Broomfield NM, McMurray JJV, et al. Cognitive impairment and heart failure: systematic review and meta-analysis. J Card Fail. 2017;23(6):464–75.  https://doi.org/10.1016/j.cardfail.2017.04.007.PubMedCrossRefGoogle Scholar
  33. Carone L, Oxberry SG, Twycross R, Charlesworth S, Mihalyo M, Wilcock A. Furosemide. J Pain Symptom Manag. 2016;52(1):144–50.  https://doi.org/10.1016/j.jpainsymman.2016.05.004.CrossRefGoogle Scholar
  34. Carrasco JM, Lynch TJ, Garralda E, Woitha K, Elsner F, Filbet M, et al. Palliative care medical education in European universities: a descriptive study and numerical scoring system proposal for assessing educational development. J Pain Symptom Manag. 2015;50(4):516–23.  https://doi.org/10.1016/j.jpainsymman.2015.04.019.CrossRefGoogle Scholar
  35. Carroll SL, Strachan PH, de Laat S, Schwartz L, Arthur HM. Patients’ decision making to accept or decline an implantable cardioverter defibrillator for primary prevention of sudden cardiac death. Health Expect. 2013a;16(1):69–79.  https://doi.org/10.1111/j.1369-7625.2011.00703.x.PubMedCrossRefGoogle Scholar
  36. Carroll SL, McGillion M, Stacey D, Healey JS, Browne G, Arthur HM, et al. Development and feasibility testing of decision support for patients who are candidates for a prophylactic implantable defibrillator: a study protocol for a pilot randomized controlled trial. Trials. 2013b;14:346.  https://doi.org/10.1186/1745-6215-14-346.PubMedPubMedCentralCrossRefGoogle Scholar
  37. Centers for Medicare & Medicaid Services, Dept of Health and Human Services. MLN matters: ventricular assist devices for bridge-to-transplant and destination therapy. https://www.cms.gov/Outreach-and-Education/Medicare-Learning-Network-MLN/MLNMattersArticles/Downloads/MM8803.pdf. Published 29 Aug 2014. Accessed 10 Oct 2017.
  38. Chamsi-Pasha H, Chamsi-Pasha MA, Albar MA. Ethical challenges of deactivation of cardiac devices in advanced heart failure. Curr Heart Fail Rep. 2014;11(2):119–25.  https://doi.org/10.1007/s11897-014-0194-8.PubMedCrossRefGoogle Scholar
  39. Chan MM, Lam CS. How do patients with heart failure with preserved ejection fraction die? Eur J Heart Fail. 2013;15:604–13.  https://doi.org/10.1093/eurjhf/hft062.PubMedCrossRefGoogle Scholar
  40. Chaudhry SI, McAvay G, Chen S, Whitson H, Newman AB, Krumholz HM, et al. Risk factors for hospital admission among older persons with newly diagnosed heart failure: findings from the cardiovascular health study. J Am Coll Cardiol. 2013;61:635–42.  https://doi.org/10.1016/j.jacc.2012.11.027.PubMedPubMedCentralCrossRefGoogle Scholar
  41. Cheang MH, Rose G, Cheung CC, Thomas M. Current challenges in palliative care provision for heart failure in the UK: a survey on the perspectives of palliative care professionals. Open Heart. 2015;2(1):e000188.  https://doi.org/10.1136/openhrt-2014-000188.PubMedPubMedCentralCrossRefGoogle Scholar
  42. Cheung WY, Schaefer K, May CW, Glynn RJ, Curtis LH, Stevenson LW, et al. Enrolment and events of hospice patients with heart failure vs. cancer. J Pain Symptom Manag. 2013;45(3):552–60.  https://doi.org/10.1016/j.jpainsymman.2012.03.006.CrossRefGoogle Scholar
  43. Clark AM, Jaarsma T, Strachan P, Davidson PM, Jerke M, Beattie JM, et al. Effective communication and ethical consent in decisions related to ICDs. Nat Rev Cardiol. 2011;8(12):694–705.  https://doi.org/10.1038/nrcardio.2011.101.PubMedCrossRefGoogle Scholar
  44. Clark AM, Dryden D, Hartling L. Systematic review of decision tools and their suitability for patient-centered decision making regarding electronic cardiac devices. Rockville: Agency for Healthcare Research and Quality; 2012.Google Scholar
  45. Clark AL, Johnson M, Fairhurst C, Torgerson D, Cockayne S, Rodgers S, et al. Does home oxygen therapy (HOT) in addition to standard care reduce disease severity and improve symptoms in people with chronic heart failure? A randomised trial of home oxygen therapy for patients with chronic heart failure. Health Technol Assess. 2015;19(75):1–120.  https://doi.org/10.3310/hta19750.CrossRefGoogle Scholar
  46. Cleland JG, McDonagh T, Rigby AS, Yassin A, Whittaker T, Dargie HJ. The national heart failure audit for England and Wales 2008–2009. Heart. 2011;97(11):876–86.  https://doi.org/10.1136/hrt.2010.209171.PubMedCrossRefGoogle Scholar
  47. Collett D, Mumford L, Banner NR, Neuberger J, Watson C. Comparison of the incidence of malignancy in recipients of different types of organ: a UK registry audit. Am J Transplant. 2010;10(8):1889–96.  https://doi.org/10.1111/j.1600-6143.2010.03181.x.PubMedCrossRefGoogle Scholar
  48. Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, et al. Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet. 2017.  https://doi.org/10.1016/S0140-6736(17)32520-5.
  49. Cook C, Cole G, Asaria P, Jabbour R, Francis DP. The annual global economic burden of heart failure. Int J Cardiol. 2014;171(3):368–76.  https://doi.org/10.1016/j.ijcard.2013.12.028.PubMedCrossRefGoogle Scholar
  50. Davidson PM, Johnson MJ. Update on the role of palliative oxygen. Curr Opin Support Palliat Care. 2011;5(2):87–91.  https://doi.org/10.1097/SPC.0b013e3283463cd3.PubMedCrossRefGoogle Scholar
  51. Davidson PM, Paull G, Introna K, Cockburn J, Davis JM, Rees D, et al. Integrated, collaborative palliative care in heart failure: the St. George heart failure service experience 1999–2002. Cardiovasc Nurs. 2004;19:68–75.CrossRefGoogle Scholar
  52. Davidson PM, Dracup K, Phillips J, Padilla G, Daly J. Maintaining hope in transition. A theoretical framework to guide interventions for people with heart failure. J Cardiovasc Nurs. 2007;22(1):58–64.PubMedCrossRefGoogle Scholar
  53. Denfeld QE, Winters-Stone K, Mudd JO, Hiatt SO, Lee CS. Identifying a relationship between physical frailty and heart failure symptoms. J Cardiovasc Nurs. 2018;33(1):E1–7.  https://doi.org/10.1097/JCN.0000000000000408.PubMedCrossRefGoogle Scholar
  54. Diop MS, Rudolph JL, Zimmerman KM, Richter MA, Skarf LM. Palliative care interventions for patients with heart failure: a systematic review and meta-analysis. J Palliat Med. 2017;20(1):84–92.  https://doi.org/10.1089/jpm.2016.0330.PubMedPubMedCentralCrossRefGoogle Scholar
  55. Dunbar SB, Dougherty CM, Sears SF, Carroll DL, Goldstein NE, Mark DB, American Heart Association Council on Cardiovascular Nursing, Council on Clinical Cardiology, and Council on Cardiovascular Disease in the Young, et al. Educational and psychological interventions to improve outcomes for recipients of implantable cardioverter defibrillators and their families: a scientific statement from the American Heart Association. Circulation. 2012;126(17):2146–72.  https://doi.org/10.1161/CIR.0b013e31825d59fd.PubMedCrossRefGoogle Scholar
  56. Dunlay SM, Roger VL. Understanding the epidemic of heart failure: past, present, and future. Curr Heart Fail Rep. 2014;11(4):404–15.  https://doi.org/10.1007/s11897-014-0220-x.PubMedPubMedCentralCrossRefGoogle Scholar
  57. Dunlay SM, Swetz KM, Mueller PS, Roger VL. Advance directives in community patients with heart failure. Circ Cardiovasc Qual Outcomes. 2012;5(3): 283–9.  https://doi.org/10.1161/CIRCOUTCOMES.112.966036.PubMedPubMedCentralCrossRefGoogle Scholar
  58. Dunlay SM, Strand JJ, Wordingham SE, Stulak JM, Luckhardt AJ, Swetz KM. Dying with a left ventricular assist device as destination therapy. Circ Heart Fail. 2016;9(10):e003096.  https://doi.org/10.1161/CIRCHEARTFAILURE.116.003096.PubMedPubMedCentralCrossRefGoogle Scholar
  59. Eckerblad J, Theander K, Ekdahl A, Unosson M, Wirehn AB, Milberg A, et al. Symptom burden in community-dwelling older people with multimorbidity: a cross-sectional study. BMC Geriatr. 2015;15:1.  https://doi.org/10.1186/1471-2318-15-1.PubMedPubMedCentralCrossRefGoogle Scholar
  60. Epstein AE, DiMarco JP, Ellenbogen KA, Estes NA 3rd, Freedman RA, Gettes LS, American College of Cardiology Foundation, American Heart Association Task Force on Practice Guidelines, Heart Rhythm Society, et al. 2012 ACCF/AHA/HRS focused update incorporated into the ACCF/AHA/HRS 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2013;61(3):e6–75.  https://doi.org/10.1016/j.jacc.2012.11.007.PubMedCrossRefGoogle Scholar
  61. Etkind SN, Bristowe K, Bailey K, Selman LE, Murtagh FEM. How does uncertainty shape patient experience in advanced illness? A secondary analysis of quantitative data. Palliat Med. 2017;31(2):171–80.  https://doi.org/10.1177/0269216316647610.PubMedCrossRefGoogle Scholar
  62. Evangelista LS, Liao S, Motie M, De Michelis N, Lombardo D. On-going palliative care enhances perceived control and patient activation and reduces symptom distress in patients with symptomatic heart failure: a pilot study. Eur J Cardiovasc Nurs. 2014;13(2):116–23.  https://doi.org/10.1177/1474515114520766.PubMedPubMedCentralCrossRefGoogle Scholar
  63. Ezekowitz JA, Thai V, Hodnefield TS, Sanderson L, Cujec B. The correlation of standard heart failure assessment and palliative care questionnaires in a multidisciplinary heart failure clinic. J Pain Symptom Manag. 2011;42:379–87.  https://doi.org/10.1016/j.jpainsymman.2010.11.013.CrossRefGoogle Scholar
  64. Fan H, Yu W, Zhang Q, Cao H, Li J, Wang J, Shao Y, Hu X. Depression after heart failure and risk of cardiovascular and all-cause mortality: a meta-analysis. Prev Med. 2014;63:36–42.  https://doi.org/10.1016/j.ypmed.2014.03.007.PubMedCrossRefGoogle Scholar
  65. Fang JC, Ewald GA, Allen LA, Butler J, Westlake Canary CA, Heart Failure Society of America Guidelines Committee, et al. Advanced (stage D) heart failure: a statement from the Heart Failure Society of America Guidelines Committee. J Card Fail. 2015;21(6):519–34.  https://doi.org/10.1016/j.cardfail.2015.04.013.PubMedCrossRefGoogle Scholar
  66. Farless LB, Steil N, Williams BR, Bailey FA. Intermittent subcutaneous furosemide: parenteral diuretic rescue for hospice patients with congestive heart failure resistant to oral diuretic. Am J Hosp Palliat Care. 2013;30:791–2.  https://doi.org/10.1177/1049909112465795.PubMedCrossRefGoogle Scholar
  67. Felker GM, Lee KL, Bull DA, Redfield MM, Stevenson LW, Goldsmith SR, NHLBI Heart Failure Clinical Research Network, et al. Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med. 2011;364:797–805.  https://doi.org/10.1056/NEJMoa1005419.PubMedPubMedCentralCrossRefGoogle Scholar
  68. Fendler TJ, Swetz KM, Allen LA. Team-based palliative and end-of-life care for heart failure. Heart Fail Clin. 2015;11(3):479–98.  https://doi.org/10.1016/j.hfc.2015.03.010.PubMedPubMedCentralCrossRefGoogle Scholar
  69. Fluur C, Bolse K, Strömberg A, Thylén I. Spouses’ reflections on implantable cardioverter defibrillator treatment with focus on the future and the end-of-life: a qualitative content analysis. J Adv Nurs. 2014;70(8):1758–69.  https://doi.org/10.1111/jan.12330.PubMedCrossRefGoogle Scholar
  70. Fried LP, Borhani NO, Enright P, Furberg CD, Gardin JM, Kronmal RA, et al. The cardiovascular health study: design and rationale. Ann Epidemiol. 1991;1:263–76.PubMedCrossRefGoogle Scholar
  71. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Cardiovascular Health Study Collaborative Research Group, et al. Frailty in older adults evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56:M146–56.PubMedCrossRefGoogle Scholar
  72. Fromme EK, Stewart TL, Jeppesen M, Tolle SW. Adverse experiences with implantable defibrillators in Oregon hospices. Am J Hosp Palliat Care. 2011;28(5):304–9.  https://doi.org/10.1177/1049909110390505.PubMedCrossRefGoogle Scholar
  73. Galbraith S, Fagan P, Perkins P, Lynch A, Booth S. Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manag. 2010;39:831–8.  https://doi.org/10.1016/j.jpainsymman.2009.09.024.CrossRefGoogle Scholar
  74. Gandesbery B, Dobbie K, Gorodeski EZ. Outpatient palliative cardiology service embedded within a heart failure clinic: experiences with an emerging model of care. Am J Hosp Palliat Care. 2017.  https://doi.org/10.1177/1049909117729478.
  75. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta. 2012;1823(9):1434–43.  https://doi.org/10.1016/j.bbamcr.2012.01.014.PubMedPubMedCentralCrossRefGoogle Scholar
  76. Gelfman LP, Kavalieratos D, Teuteberg WG, Lala A, Goldstein NE. Primary palliative care for heart failure: what is it? How do we implement it? Heart Fail Rev. 2017a;22(5):611–20.  https://doi.org/10.1007/s10741-017-9604-9.PubMedCrossRefGoogle Scholar
  77. Gelfman LP, Bakitas M, Warner Stevenson L, Kirkpatrick JN, Goldstein NE, and on behalf of the Improving Palliative Care for Patients with Heart Failure and Their Families (IMPACT-HF) Working Group. The state of the science on integrating palliative care in heart failure. J Palliat Med. 2017b;20(6):592–603.PubMedCrossRefGoogle Scholar
  78. Gerber Y, Weston SA, Redfield MM, Chamberlain AM, Manemann SM, Jiang R, et al. A contemporary appraisal of the heart failure epidemic in Olmsted County, Minnesota, 2000 to 2010. JAMA Intern Med. 2015;175(6):996–1004.  https://doi.org/10.1001/jamainternmed.2015.0924.PubMedPubMedCentralCrossRefGoogle Scholar
  79. Goldstein NE, Lampert R, Bradley E, Lynn J, Krumholz HM. Management of implantable cardioverter defibrillators in end-of-life care. Ann Intern Med. 2004;141(11):835–8.PubMedCrossRefGoogle Scholar
  80. Goldstein NE, Mehta D, Siddiqui S, Teitelbaum E, Zeidman J, Singson M, et al. “That’s like an act of suicide” patients’ attitudes toward deactivation of implantable defibrillators. J Gen Intern Med. 2008a;23(Suppl 1):7–12.  https://doi.org/10.1007/s11606-007-0239-8.PubMedCrossRefGoogle Scholar
  81. Goldstein NE, Mehta D, Teitelbaum E, Bradley EH, Morrison RS. “It’s like crossing a bridge” complexities preventing physicians from discussing deactivation of implantable defibrillators at the end of life. J Gen Intern Med. 2008b;23(Suppl 1):2–6.  https://doi.org/10.1007/s11606-007-0237-x.PubMedCrossRefGoogle Scholar
  82. Goldstein N, Carlson M, Livote E, Kutner JS. Brief communication: management of implantable cardioverter defibrillators in hospice: a nationwide survey. Ann Intern Med. 2010;152:296–9.  https://doi.org/10.7326/0003-4819-152-5-201003020-00007.PubMedPubMedCentralCrossRefGoogle Scholar
  83. Goldstein NE, May CW, Meier DE. Comprehensive care for mechanical circulatory support: a new frontier for synergy with palliative care. Circ Heart Fail. 2011;4:519–27.  https://doi.org/10.1161/CIRCHEARTFAILURE.110.957241.PubMedPubMedCentralCrossRefGoogle Scholar
  84. Goldstein DJ, Naftel D, Holman W, Bellumkonda L, Pamboukian SV, Pagani FD, et al. Continuous-flow devices and percutaneous site infections: clinical outcomes. J Heart Lung Transplant. 2012;31(11):1151–7.  https://doi.org/10.1016/j.healun.2012.05.004.PubMedCrossRefGoogle Scholar
  85. Gómez-Batiste X, Martinez-Muñoz M, Blay C, Amblàs J, Vila L, Costa X, et al. Identifying chronic patients in need of palliative care in the general population: development of the NECPAL tool and preliminary prevalence rates in Catalonia. BMJ Support Palliat Care. 2013;3:300–8.  https://doi.org/10.1136/bmjspcare-2012-000211.PubMedCrossRefGoogle Scholar
  86. Goodlin SJ, Hauptman PJ, Arnold R, Grady K, Hershberger RE, Kutner J, et al. Consensus statement: palliative and supportive care in advanced heart failure. J Card Fail. 2004;10(3):200–9.PubMedCrossRefGoogle Scholar
  87. Gott M, Barnes S, Parker C, Payne S, Seamark D, Gariballa S, et al. Dying trajectories in heart failure. Palliat Med. 2007;21:95–9.  https://doi.org/10.1177/0269216307076348.PubMedCrossRefGoogle Scholar
  88. Green CP, Porter CB, Bresnahan DR, Spertus JA. Development and evaluation of the Kansas City cardiomyopathy questionnaire: a new health status measure for heart failure. J Am Coll Cardiol. 2000;35:1245–55.PubMedCrossRefGoogle Scholar
  89. Green AR, Leff B, Wang Y, Spatz ES, Masoudi FA, Peterson PN, et al. Geriatric conditions in patients undergoing defibrillator implantation for prevention of sudden cardiac death: prevalence and impact on mortality. Circ Cardiovasc Qual Outcomes. 2016;9(1):23–30.  https://doi.org/10.1161/CIRCOUTCOMES.115.002053.PubMedCrossRefGoogle Scholar
  90. Guha K, McDonagh T. Heart failure epidemiology: European perspective. Curr Cardiol Rev. 2013;9(2): 123–7.PubMedPubMedCentralCrossRefGoogle Scholar
  91. Hauptman PJ, Mikolajczak P, George A, Mohr CJ, Hoover R, Swindle J, et al. Chronic inotropic therapy in end-stage heart failure. Am Heart J. 2006;152:1096.e1–8.  https://doi.org/10.1016/j.ahj.2006.08.003.CrossRefGoogle Scholar
  92. Hauptman PJ, Chibnall JT, Guild C, Armbrecht ES. Patient perceptions, physician communication, and the implantable cardioverter-defibrillator. JAMA Intern Med. 2013;173(7):571–7.  https://doi.org/10.1001/jamainternmed.2013.3171.PubMedCrossRefGoogle Scholar
  93. Hill L, McIlfatrick S, Taylor BJ, Dixon L, Cole BR, Moser DK, et al. Implantable cardioverter defibrillator (ICD) deactivation discussions: reality versus recommendations. Eur J Cardiovasc Nurs. 2016;15(1):20–9.  https://doi.org/10.1177/1474515115584248.PubMedCrossRefGoogle Scholar
  94. Hindricks G, Camm J, Merkely B, Raatikainen P, Amar DO. The EHRA White Book, 10th ed. European Heart Rhythm Association. 2017. https://www.escardio.org/static_file/Escardio/Subspecialty/EHRA/Publications/Documents/2017/ehra-white-book-2017.pdf. Accessed 2 Nov 2017.
  95. Hogg KJ, Jenkins SM. Prognostication or identification of palliative needs in advanced heart failure: where should the focus lie? Heart. 2012;98(7):523–4.  https://doi.org/10.1136/heartjnl-2012-301753.PubMedCrossRefGoogle Scholar
  96. Holland R, Rechel B, Stepien K, Harvey I, Brooksby I. Patients’ self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death. J Card Fail. 2010;16(2):150–6.  https://doi.org/10.1016/j.cardfail.2009.08.010.PubMedPubMedCentralCrossRefGoogle Scholar
  97. Hopp FP, Zalenski RJ, Waselewsky D, Burn J, Camp J, Welch RD, et al. Results of a hospital-based palliative care intervention for patients with an acute exacerbation of chronic heart failure. J Card Fail. 2016;22(12): 1033–6.  https://doi.org/10.1016/j.cardfail.2016.04.004.PubMedCrossRefGoogle Scholar
  98. Huffman MD, Berry JD, Ning H, Dyer AR, Garside DB, Cai X, et al. Lifetime risk for heart failure among white and black Americans cardiovascular lifetime risk pooling project. J Am Coll Cardiol. 2013;61:1510–7.  https://doi.org/10.1016/j.jacc.2013.01.022.PubMedPubMedCentralCrossRefGoogle Scholar
  99. Hunt SA, Baker DW, Chin MH, Cinquegrani MP, Feldman AM, Francis GS, American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure), International Society for Heart and Lung Transplantation, Heart Failure Society of America, et al. ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee to revise the 1995 guidelines for the evaluation and management of heart failure): developed in collaboration with the International Society for Heart and Lung Transplantation; endorsed by the Heart Failure Society of America. Circulation. 2001;104(24):2996–3007.  https://doi.org/10.1161/hc4901.102568.PubMedCrossRefGoogle Scholar
  100. Ismail Y, Nightingale AK, Shorthouse K. Trainee experience of delivering end-of-life care in heart failure: key findings of a national survey. Br J Cardiol. 2015;22:26.  https://doi.org/10.5837/bjc.2015.008.Google Scholar
  101. Jaarsma T, Beattie JM, Ryder M, Rutten FH, McDonagh T, Mohacsi P, Advanced Heart Failure Study Group of the HFA of the ESC, et al. Palliative care in heart failure: a position statement from the palliative care workshop of the heart failure Association of the European Society of cardiology. Eur J Heart Fail. 2009;11(5):433–43.  https://doi.org/10.1093/eurjhf/hfp041.PubMedCrossRefGoogle Scholar
  102. Jani B, Blane D, Browne S, Montori V, May C, Shippee N, et al. Identifying treatment burden as an important concept for end of life care in those with advanced heart failure. Curr Opin Support Palliat Care. 2013;7(1):3–7.  https://doi.org/10.1097/SPC.0b013e32835c071f.PubMedCrossRefGoogle Scholar
  103. Jankowska EA, Malyszko J, Ardehali H, Koc-Zorawska E, Banasiak W, von Haehling S, et al. Iron status in patients with chronic heart failure. Eur Heart J. 2013;34(11):827–34.  https://doi.org/10.1093/eurheartj/ehs377.PubMedCrossRefGoogle Scholar
  104. Janssen DJA, Johnson MJ, Spruit MA. Palliative care needs assessment in chronic heart failure. Curr Opin Support Palliat Care. 2018;12(1):25–31.  https://doi.org/10.1097/SPC.0000000000000317.
  105. Jermyn R, Patel S. The biologic syndrome of frailty in heart failure. Clin Med Insights Cardiol. 2015;8(Suppl 1):87–92.  https://doi.org/10.4137/CMC.S15720.PubMedPubMedCentralGoogle Scholar
  106. Jha SR, Ha HS, Hickman LD, Hannu M, Davidson PM, Macdonald PS, et al. Frailty in advanced heart failure: a systematic review. Heart Fail Rev. 2015;20(5):553–60.  https://doi.org/10.1007/s10741-015-9493-8.PubMedCrossRefGoogle Scholar
  107. Johnson MJ, Clark AL. The mechanisms of breathlessness in heart failure as the basis of therapy. Curr Opin Support Palliat Care. 2016;10(1):32–5.  https://doi.org/10.1097/SPC.0000000000000181.PubMedCrossRefGoogle Scholar
  108. Johnson MJ, McDonagh T, Harkness A, MacKay S, Dargie H. Morphine for breathlessness in chronic heart failure. Eur J Heart Fail. 2002;4:753–6.PubMedCrossRefGoogle Scholar
  109. Johnson M, Hogg K, Beattie J. Heart failure: from advanced disease to bereavement. Oxford: Oxford University Press; 2012a.CrossRefGoogle Scholar
  110. Johnson MJ, MacCallum A, Butler J, Rogers A, Sam E, Fuller A, et al. Heart failure specialist nurses’ use of palliative care services: a comparison of surveys across England in 2005 and 2010. Eur J Cardiovasc Nurs. 2012b;11(2):190–6.  https://doi.org/10.1016/j.ejcnurse.2011.03.004.PubMedCrossRefGoogle Scholar
  111. Johnson MJ, Nunn A, Hawkes T, Stockdale S, Daley A. Planning for end of life care in people with heart failure: experience of two integrated cardiology-palliative care teams. Br J Cardiol. 2012c;19:71–5.  https://doi.org/10.5837/bjc.2012.014.CrossRefGoogle Scholar
  112. Johnson MJ, Bland JM, Davidson PM, Newton PJ, Oxberry SG, Abernethy AP, et al. The relationship between two performance scales: New York Heart Association Classification and Karnofsky Performance Status Scale. J Pain Symptom Manag. 2014;47:652–8.  https://doi.org/10.1016/j.jpainsymman.2013.05.006.CrossRefGoogle Scholar
  113. Joyce KE, Lord S, Matlock DD, McComb JM, Thomson R. Incorporating the patient perspective: a critical review of clinical practice guidelines for implantable cardioverter defibrillator therapy. J Interv Card Electrophysiol. 2013;36:185–97.  https://doi.org/10.1007/s10840-012-9762-6.PubMedCrossRefGoogle Scholar
  114. Jurgens CY, Moser DK, Armola R, Carlson B, Sethares K, Riegel B, Heart Failure Quality of Life Trialist Collaborators. Symptom clusters of heart failure. Res Nurs Health. 2009;32:551–60.  https://doi.org/10.1002/nur.20343.PubMedPubMedCentralCrossRefGoogle Scholar
  115. Kane PM, Murtagh FE, Ryan K, Mahon NG, McAdam B, McQuillan R, et al. The gap between policy and practice: a systematic review of patient-centred care interventions in chronic heart failure. Heart Fail Rev. 2015;20:673–87.  https://doi.org/10.1007/s10741-015-9508-5.PubMedPubMedCentralCrossRefGoogle Scholar
  116. Kane PM, Daveson BA, Ryan K, Ellis-Smith CI, Mahon NG, McAdam B, BuildCARE, et al. Feasibility and acceptability of a patient-reported outcome intervention in chronic heart failure. BMJ Support Palliat Care. 2017:7(4):470–9.  https://doi.org/10.1136/bmjspcare-2017-001355.
  117. Kaufman SR, Meuller PS, Ottenberg AL, Koenig BA. Ironic technology: old age and the implantable defibrillator in US health care. Soc Sci Med. 2011;72(1):6–14.  https://doi.org/10.1016/j.socscimed.2010.09.052.PubMedCrossRefGoogle Scholar
  118. Kheirbek RE, Fletcher RD, Bakitas MA, Fonarow GC, Parvtaneni S, Bearden D, et al. Discharge hospice referral and lower 30-day all-cause readmission in Medicare beneficiaries hospitalized for heart failure. Circ Heart Fail. 2015;8:733–40.  https://doi.org/10.1161/CIRCHEARTFAILURE.115.002153.PubMedPubMedCentralCrossRefGoogle Scholar
  119. Kim J, Pressler SJ, Groh WJ. Change in cognitive function over 12 months among patients with an implantable cardioverter-defibrillator. J Cardiovasc Nurs. 2013;28(6):e28–36.  https://doi.org/10.1097/JCN.0b013e31829dfc6e.PubMedCrossRefGoogle Scholar
  120. Kinch Westerdahl A, Sjöblom J, Mattiasson AC, Rosenqvist M, Frykman V. Implantable defibrillator therapy before death. High risk of painful shocks near the end of life. Circulation. 2014;129:422–9.  https://doi.org/10.1161/CIRCULATIONAHA.113.002648.PubMedCrossRefGoogle Scholar
  121. Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Stevenson LW, et al. Seventh INTERMACS annual report: 15,000 patients and counting. J Heart Lung Transplant. 2015;34(12):1495–504.  https://doi.org/10.1016/j.healun.2015.10.003.PubMedCrossRefGoogle Scholar
  122. Kirkpatrick JN, Wieselthaler G, Strueber M, St John Sutton MG, Rame JE. Ventricular assist devices for treatment of acute heart failure and chronic heart failure. Heart. 2015;101(14):1091–6.  https://doi.org/10.1136/heartjnl-2014-306789.PubMedCrossRefGoogle Scholar
  123. Kramer DB, Kesselheim AS, Brock DW, Maisel WH. Ethical and legal views of physicians regarding deactivation of cardiac implantable electrical devices: a quantitative assessment. Heart Rhythm. 2010;7(11): 1537–42.  https://doi.org/10.1016/j.hrthm.2010.07.018.PubMedPubMedCentralCrossRefGoogle Scholar
  124. Kramer DB, Ottenberg AL, Gerhardson S, Mueller LA, Kaufman SR, Koenig BA, et al. “Just because we can doesn’t mean we should”: views of nurses on deactivation of pacemakers and implantable cardioverter-defibrillators. J Interv Card Electrophysiol. 2011;32(3):243–52.  https://doi.org/10.1007/s10840-011-9596-7.PubMedPubMedCentralCrossRefGoogle Scholar
  125. Kramer DB, Matlock DD, Buxton AE, Goldstein NE, Goodwin C, Green AR, et al. Implantable cardioverter-defibrillator use in older adults: proceedings of a Hartford change AGEnts symposium. Circ Cardiovasc Qual Outcomes. 2015;8(4):437–46.  https://doi.org/10.1161/CIRCOUTCOMES.114.001660.PubMedPubMedCentralCrossRefGoogle Scholar
  126. Kramer DB, Reynolds MR, Normand SL, Parzynski CS, Spertus JA, Mor V, et al. Hospice use following implantable cardioverter-defibrillator implantation in older patients: results from the National Cardiovascular Data Registry. Circulation. 2016;133(21):2030–7.  https://doi.org/10.1161/CIRCULATIONAHA.115.020677.PubMedPubMedCentralCrossRefGoogle Scholar
  127. Kute VB, Vanikar AV, Patel HV, Gumber MR, Shah PR, Engineer DP, et al. Significant benefits after renal transplantation in patients with chronic heart failure and chronic kidney disease. Ren Fail. 2014;36(6):854–8.  https://doi.org/10.3109/0886022X.2014.899474.PubMedCrossRefGoogle Scholar
  128. Lam CS, Solomon SD. The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%). Eur J Heart Fail. 2014;16(10):1049–55.  https://doi.org/10.1002/ejhf.159.PubMedCrossRefGoogle Scholar
  129. Lampert R, Hayes DL, Annas GJ, Farley MA, Goldstein NE, Hamilton RM, American College of Cardiology, American Geriatrics Society, American Academy of Hospice and Palliative Medicine, American Heart Association, European Heart Rhythm Association, Hospice and Palliative Nurses Association, et al. HRS expert consensus statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm. 2010;7(7):1008–26.  https://doi.org/10.1016/j.hrthm.2010.04.033.PubMedCrossRefGoogle Scholar
  130. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2015;28(1):1–39.e14.  https://doi.org/10.1016/j.echo.2014.10.003.PubMedCrossRefGoogle Scholar
  131. Lauck S, Garland E, Achtem L, Forman J, Baumbusch J, Boone R, et al. Integrating a palliative approach in a transcatheter heart valve program: bridging innovations in the management of severe aortic stenosis and best end-of-life practice. Eur J Cardiovasc Nurs. 2014;13:177–84.  https://doi.org/10.1177/1474515114520770.PubMedCrossRefGoogle Scholar
  132. Lee KS, Moser DK. Heart failure symptom measures: critical review. Eur J Cardiovasc Nurs. 2013;12(5): 418–28.  https://doi.org/10.1177/1474515112473235.PubMedCrossRefGoogle Scholar
  133. Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS. The last six months of life for patients with congestive heart failure. J Am Geriatr Soc. 2000;48(5 Suppl):S101–9.PubMedCrossRefGoogle Scholar
  134. Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, et al. The Seattle heart failure model: prediction of survival in heart failure. Circulation. 2006;113(11):1424–33.  https://doi.org/10.1161/CIRCULATIONAHA.105.584102.PubMedCrossRefGoogle Scholar
  135. Lewin WH, Cheung W, Horvath AN, Haberman S, Patel A, Sullivan D. Supportive cardiology: moving palliative care upstream for patients living with advanced heart failure. J Palliat Med. 2017;20(10): 1112–9.  https://doi.org/10.1089/jpm.2016.0317.PubMedCrossRefGoogle Scholar
  136. Lewis KB, Stacey D, Carroll SL, Boland L, Sikora L, Birnie D. Estimating the risks and benefits of implantable cardioverter defibrillator generator replacement: a systematic review. Pacing Clin Electrophysiol. 2016;39(7):709–22.  https://doi.org/10.1111/pace.12850.PubMedCrossRefGoogle Scholar
  137. Light-McGroary K, Goodlin SJ. The challenges of understanding and managing pain in the heart failure patient. Curr Opin Support Palliat Care. 2013;7:14–20.  https://doi.org/10.1097/SPC.0b013e32835c1f2f.PubMedCrossRefGoogle Scholar
  138. Lokker ME, Gwyther L, Riley JP, van Zuylen L, van fer Heide A, Harding R. The prevalence and associated distress of physical and psychological symptoms in patients with advanced heart failure attending a South African medical center. J Cardiovasc Nurs. 2016;31:313–22.  https://doi.org/10.1097/JCN.0000000000000256.PubMedCrossRefGoogle Scholar
  139. Low J, Pattenden J, Candy B, Beattie JM, Jones L. Palliative care in advanced heart failure: an international review of the perspectives of recipients and health professionals on care provision. J Card Fail. 2011;17(3):231–52.  https://doi.org/10.1016/j.cardfail.2010.10.003.PubMedCrossRefGoogle Scholar
  140. Luckett T, Phillips J, Agar M, Virdun C, Green A, Davidson PM. Elements of effective palliative care models: a rapid review. BMC Health Serv Res. 2014;14:136.  https://doi.org/10.1186/1472-6963-14-136.PubMedPubMedCentralCrossRefGoogle Scholar
  141. Lum HD, Jones J, Lahoff D, Allen LA, Bekelman DB, Kutner JS, et al. Unique challenges of hospice for patients with heart failure: a qualitative study of hospice clinicians. Am Heart J. 2015;170(3):524–30.  https://doi.org/10.1016/j.ahj.2015.06.019.PubMedPubMedCentralCrossRefGoogle Scholar
  142. Lum HD, Horney C, Koets D, Kutner JS, Matlock DD. Availability of heart failure medications in hospice care. Am J Hosp Palliat Care. 2016;33(10):924–8.  https://doi.org/10.1177/1049909115603689.PubMedCrossRefGoogle Scholar
  143. Luo N, Rogers JG, Dodson GC, Patel CB, Galanos AN, Milano CA, et al. Usefulness of palliative care to complement the management of patients on left ventricular assist devices. Am J Cardiol. 2016;118:733–8.  https://doi.org/10.1016/j.amjcard.2016.06.010.PubMedPubMedCentralCrossRefGoogle Scholar
  144. Madan SA, Fida N, Barman P, Sims D, Shin J, Verghese J, et al. Frailty assessment in advanced heart failure. J Card Fail. 2016;22(10):840–4.  https://doi.org/10.1016/j.cardfail.2016.02.003.PubMedCrossRefGoogle Scholar
  145. Martens P, Nijst P, Verbrugge FH, Smeets K, Dupont M, Mullens W. Impact of iron deficiency on exercise capacity and outcome in heart failure with reduced, mid-range and preserved ejection fraction. Acta Cardiol. 2017;21:1–9.  https://doi.org/10.1080/00015385.2017.1351239.CrossRefGoogle Scholar
  146. Mason DT. Congestive heart failure: mechanisms, evaluation and treatment. New York: Yorke Medical Books; 1976.Google Scholar
  147. Matlock DD, Jones J, Nowels CT, Jenkins A, Allen LA, Kutner JS. Evidence of cognitive bias in decision making around implantable-cardioverter defibrillators: a qualitative framework analysis. J Card Fail. 2017;23(11):794–9.  https://doi.org/10.1016/j.cardfail.2017.03.008.PubMedCrossRefGoogle Scholar
  148. McDonagh T, Macdougall IC. Iron therapy for the treatment of iron deficiency in chronic heart failure: intravenous or oral? Eur J Heart Fail. 2015;17(3):248–62.  https://doi.org/10.1002/ejhf.236.PubMedPubMedCentralCrossRefGoogle Scholar
  149. McDonagh TA, Blue L, Clark AL, Dahlström U, Ekman I, Lainscak M, al w. European Society of Cardiology Heart Failure Association standards for delivering heart failure care. Eur J Heart Fail. 2011;13:235–41.  https://doi.org/10.1093/eurjhf/hfq221.PubMedCrossRefGoogle Scholar
  150. McDonagh TA, Gardner RS, Lainscak M, Nielsen OW, Parissis J, Filippatos G, et al. Heart failure Association of the European Society of cardiology specialist heart failure curriculum. Eur J Heart Fail. 2014;16(2): 151–62.  https://doi.org/10.1002/ejhf.41.PubMedCrossRefGoogle Scholar
  151. McDonagh J, Martin L, Ferguson C, Jha SR, Macdonald PS, Davidson PM, et al. Frailty assessment instruments in heart failure: a systematic review. Eur J Cardiovasc Nurs. 2018;17(1):23–35.  https://doi.org/10.1177/1474515117708888.PubMedCrossRefGoogle Scholar
  152. McIIvennan CK, Jones J, Allen LA, Swetz KM, Nowels C, Matlock DD. Bereaved caregiver perspectives on the end-of-life experience of patients with a left ventricular assist device. JAMA Intern Med. 2016;176(4):534–9.  https://doi.org/10.1001/jamainternmed.2015.8528.CrossRefGoogle Scholar
  153. McKelvie RS, Moe GW, Cheung A, Costigan J, Ducharme A, Estrella-Holder E, et al. The 2011 Canadian cardiovascular society heart failure management guidelines update: focus on sleep apnea, renal dysfunction, mechanical circulatory support, and palliative care. Can J Cardiol. 2011;27(3):319–38.  https://doi.org/10.1016/j.cjca.2011.03.011.PubMedCrossRefGoogle Scholar
  154. McKenna M, Clark SC. Palliative care in cardiopulmonary transplantation. BMJ Support Palliat Care. 2015;5(4):427–34.  https://doi.org/10.1136/bmjspcare-2014-000769.PubMedCrossRefGoogle Scholar
  155. Merchant FM, Binney Z, Patel A, Li J, Peddareddy LP, El-Chami MF, et al. Prevalence, predictors, and outcomes of advance directives in implantable cardioverter-defibrillator recipients. Heart Rhythm. 2017;14(6):830–6.  https://doi.org/10.1016/j.hrthm.2017.02.022.PubMedCrossRefGoogle Scholar
  156. Meyers DE, Goodlin SJ. End-of-life decisions and palliative care in advanced heart failure. Can J Cardiol. 2016;32(9):1148–56.  https://doi.org/10.1016/j.cjca.2016.04.015.PubMedCrossRefGoogle Scholar
  157. Moraska AR, Chamberlain AM, Shah ND, Vickers KS, Rummans TA, Dunlay SM, et al. Depression, healthcare utilization, and death in heart failure: a community study. Circ Heart Fail. 2013;6(3):387–94.  https://doi.org/10.1161/CIRCHEARTFAILURE.112.000118.PubMedPubMedCentralCrossRefGoogle Scholar
  158. Moser DK, Lee KS, Wu JR, Mudd-Martin G, Jaarsma T, Huang TY, et al. Identification of symptom clusters among patients with heart failure: an international observational study. Int J Nurs Stud. 2014;51:1366–72.  https://doi.org/10.1016/j.ijnurstu.2014.02.004.PubMedPubMedCentralCrossRefGoogle Scholar
  159. Muhandiramge D, Udeoji DU, Biswas OS, Bharadwaj P, Black LZ, Mulholland KA, et al. Palliative care issues in heart transplant candidates. Curr Opin Support Palliat Care. 2015;9(1):5–13.  https://doi.org/10.1097/SPC.0000000000000112.PubMedCrossRefGoogle Scholar
  160. Munoz-Mendoza J. Competencies in palliative care for cardiology fellows. J Am Coll Cardiol. 2015;65: 750–2.  https://doi.org/10.1016/j.jacc.2014.12.030.PubMedCrossRefGoogle Scholar
  161. Murray SA, Kendall M, Grant E, Boyd K, Barclay S, Sheikh A. Patterns of social, psychological, and spiritual decline toward the end of life in lung cancer and heart failure. J Pain Symptom Manag. 2007;34(4):393–402.  https://doi.org/10.1016/j.jpainsymman.2006.12.009.CrossRefGoogle Scholar
  162. Nakagawa S, Yuzefpolskaya M, Colombo PC, Naka Y, Blinderman CD. Palliative care interventions before left ventricular assist device implantation in both bridge to transplant and destination therapy. J Palliat Med. 2017;20(9):977–83.  https://doi.org/10.1089/jpm.2016.0568.PubMedCrossRefGoogle Scholar
  163. National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand (Chronic Heart Failure Guidelines Expert Writing Panel). Guidelines for the prevention, detection and management of chronic heart failure in Australia. Updated October 2011. Document PRO-119.v2. https://www.heartfoundation.org.au/.../Chronic_Heart_Failure_Guidelines_2011.pdf. Accessed 12 Nov 2017.
  164. Niewald A, Broxterman J, Rosell T, Rigler S. Documented consent process for implantable cardioverter-defibrillators and implications for end-of-life care in older adults. J Med Ethics. 2013;39:94–7.  https://doi.org/10.1136/medethics-2012-100613.PubMedCrossRefGoogle Scholar
  165. O’Leary N, Murphy NF, O’Loughlin C, Tiernan E, McDonald K. A comparative study of the palliative care needs of heart failure and cancer patients. Eur J Heart Fail. 2009;11:406–12.  https://doi.org/10.1093/eurjhf/hfp007.PubMedCrossRefGoogle Scholar
  166. Opasich C, Gualco A, De Feo S, Barbieri M, Cioffi G, Giardini A, et al. Physical and emotional symptom burden of patients with end-stage heart failure: what to measure, how and why. J Cardiovasc Med (Hagerstown). 2008;9(11):1104–8.  https://doi.org/10.2459/JCM.0b013e32830c1b45.CrossRefGoogle Scholar
  167. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med. 2006;355:251–9.  https://doi.org/10.1056/NEJMoa052256.PubMedCrossRefGoogle Scholar
  168. Oxberry SG, Torgerson DT, Bland M, Clark AL, Cleland JG, Johnson MJ. Short-term opioids for breathlessness in stable chronic heart failure: a randomised controlled trial. Eur J Heart Fail. 2011;13:1006–12.  https://doi.org/10.1093/eurjhf/hfr068.PubMedCrossRefGoogle Scholar
  169. Oxberry SG, Bland JM, Clark AL, Cleland JG, Johnson MJ. Repeat dose opioids may be effective for breathlessness in chronic heart failure if given for long enough. J Palliat Med. 2013;16:250–5.  https://doi.org/10.1089/jpm.2012.0270.PubMedCrossRefGoogle Scholar
  170. Padeletti L, Arnar DO, Boncinelli L, Brachman J, Camm JA, Daubert JC, European Heart Rhythm Association, Heart Rhythm Society, et al. EHRA expert consensus statement on the management of cardiovascular implantable electronic devices in patients nearing end of life or requesting withdrawal of therapy. Europace. 2010;12(10):1480–9.  https://doi.org/10.1093/europace/euq275.PubMedCrossRefGoogle Scholar
  171. Palazzuoli A, Ruocco G, Vescovo G, Valle R, Di Somma S, Nuti R. Rationale and study design of intravenous loop diuretic administration in acute heart failure: DIUR-AHF. ESC Heart Fail. 2017;4(4):479–86.  https://doi.org/10.1002/ehf2.12226.PubMedPubMedCentralCrossRefGoogle Scholar
  172. Park J, Johantgen ME. A cross-cultural comparison of symptom reporting and symptom clusters in heart failure. J Transcult Nurs. 2017;28(4):372–80.  https://doi.org/10.1177/1043659616651673.PubMedCrossRefGoogle Scholar
  173. Pasalic D, Gazelka HM, Topazian RJ, Buchhalter LC, Ottenberg AL, Webster TL, et al. Palliative care consultation and associated end-of-life care after pacemaker or implantable cardioverter-defibrillator deactivation. Am J Hosp Palliat Care. 2016;33(10): 966–71.  https://doi.org/10.1177/1049909115595017.PubMedCrossRefGoogle Scholar
  174. Pattenden JF, Mason AR, Lewin RJP. Collaborative palliative care for advanced heart failure: outcomes and costs from the “better together” pilot study. BMJ Support Palliat Care. 2013;3:69–76.  https://doi.org/10.1136/bmjspcare-2012-000251.PubMedCrossRefGoogle Scholar
  175. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62(4):263–71.  https://doi.org/10.1016/j.jacc.2013.02.092.PubMedCrossRefGoogle Scholar
  176. Pitcher D, Soar J, Hogg K, Linker N, Chapman S, Beattie JM, CIED Working Group, et al. Cardiovascular implanted electronic devices in people towards the end of life, during cardiopulmonary resuscitation and after death: guidance from the Resuscitation Council (UK), British Cardiovascular Society and National Council for palliative care. Heart. 2016;102(Suppl 7):A1–A17.  https://doi.org/10.1136/heartjnl-2016-309721.PubMedCrossRefGoogle Scholar
  177. Pocock SJ, Ariti CA, McMurray JJ, Maggioni A, Køber L, Squire IB, Meta-Analysis Global Group In Chronic Heart Failure, et al. Predicting survival in heart failure: a risk score based on 39 372 patients from 30 studies. Eur Heart J. 2013;34(19):1404–13.  https://doi.org/10.1093/eurheartj/ehs337.PubMedCrossRefGoogle Scholar
  178. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the heart failure association (HFA) of the ESC. Eur J Heart Fail. 2016;18(8):891–975.  https://doi.org/10.1002/ejhf.592.PubMedCrossRefGoogle Scholar
  179. Quill TE, Abernethy AP. Generalist plus specialist palliative care – creating a more sustainable model. N Engl J Med. 2013;68(13):1173–5.  https://doi.org/10.1056/NEJMp1215620.CrossRefGoogle Scholar
  180. Raphael C, Briscoe C, Davies J, Whinnett ZI, Manisty C, Sutton R, et al. Limitations of the New York heart association functional classification system and self-reported walking distances in chronic heart failure. Heart. 2007;93(4):476–82.  https://doi.org/10.1136/hrt.2006.089656.PubMedCrossRefGoogle Scholar
  181. Rector TS, Kubo SH, Cohn JN. Patients self-assessment of their congestive heart failure: content, reliability and validity of a new measure, the Minnesota living with heart failure questionnaire. Heart Fail. 1987;3: 198–209.Google Scholar
  182. Rich MW, Chyun DA, Skolnick AH, Alexander KP, Forman DE, Kitzman DW, American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Cardiovascular Surgery and Anesthesia, and Stroke Council, American College of Cardiology, American Geriatrics Society, et al. Knowledge gaps in cardiovascular care of the older adult population: a scientific statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society. Circulation. 2016;133(21):2103–22.  https://doi.org/10.1111/jgs.14576.PubMedCrossRefGoogle Scholar
  183. Riley PL, Arslanian-Engoren C. Cognitive dysfunction and self-care decision making in chronic heart failure: a review of the literature. Eur J Cardiovasc Nurs. 2013;12(6):505–11.  https://doi.org/10.1177/1474515113487463.PubMedCrossRefGoogle Scholar
  184. Riley JP, Beattie JM. Palliative care in heart failure: facts and numbers. ESC Heart Fail. 2017;4(2):81–7.  https://doi.org/10.1002/ehf2.12125.PubMedCrossRefGoogle Scholar
  185. Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646–59.  https://doi.org/10.1161/CIRCRESAHA.113.300268.PubMedPubMedCentralCrossRefGoogle Scholar
  186. Rogers JG, Patel CB, Mentz RJ, Granger BB, Steinhauser KE, Fiuzat M, et al. Palliative care in heart failure the PAL-HF randomized, controlled clinical trial. J Am Coll Cardiol. 2017;70(3):331–41.  https://doi.org/10.1016/j.jacc.2017.05.030.PubMedCrossRefGoogle Scholar
  187. Russ AJ, Kaufman SR. Family perceptions of prognosis, silence, and the “suddenness” of death. Cult Med Psychiatry. 2005;29(1):103–23.PubMedCrossRefGoogle Scholar
  188. Russo AM, Stainback RF, Bailey SR, Epstein AE, Heidenreich PA, Jessup M, et al. ACC/HRS/AHA/ASE/HFSA/SCAI/SCCT/SCMR 2013 appropriate use criteria for implantable cardioverter-defibrillators and cardiac resynchronization therapy: a report of the American College of Cardiology Foundation appropriate use criteria task force, Heart Rhythm Society, American Heart Association, American Society of Echocardiography, Heart Failure Society of America, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. Heart Rhythm. 2013;10(4):e11–58.  https://doi.org/10.1016/j.hrthm.2013.01.008.PubMedCrossRefGoogle Scholar
  189. Rustad JK, Stern TA, Hebert KA, Musselman DL. Diagnosis and treatment of depression in patients with congestive heart failure: a review of the literature. Prim Care Companion CNS Disord. 2013;15(4).  https://doi.org/10.4088/PCC.13r01511.
  190. Ryder M, Beattie JM, O’Hanlon R, McDonald K. Multidisciplinary heart failure management and end of life care. Curr Opin Support Palliat Care. 2011;5(4):317–21.  https://doi.org/10.1097/SPC.0b013e32834d749e.PubMedCrossRefGoogle Scholar
  191. Sagin A, Kirkpatrick JN, Pisani BA, Fahlberg BB, Sundlof AL, O’Connor NR. Emerging collaboration between palliative care specialists and mechanical circulatory support teams: a qualitative study. J Pain Symptom Manag. 2016;52:491–7.  https://doi.org/10.1016/j.jpainsymman.2016.03.017.CrossRefGoogle Scholar
  192. Sartipy U, Dahlström U, Edner M, Lund LH. Predicting survival in heart failure: validation of the MAGGIC heart failure risk score in 51,043 patients from the Swedish heart failure registry. Eur J Heart Fail. 2014;16(2):173–9.  https://doi.org/10.1111/ejhf.32.PubMedCrossRefGoogle Scholar
  193. Schefold JC, Filippatos G, Hasenfuss G, Anker SD, von Haehling S. Heart failure and kidney dysfunction: epidemiology, mechanisms and management. Nat Rev Nephrol. 2016;12(10):610–23.  https://doi.org/10.1038/nrneph.2016.113.PubMedCrossRefGoogle Scholar
  194. Schwarz ER, Baraghoush A, Morrissey RP, Shah AB, Shinde AM, Phan A, et al. Pilot study of palliative care consultation in patients with advanced heart failure referred for cardiac transplantation. J Palliat Med. 2012;15(1):12–15.  https://doi.org/10.1089/jpm.2011.0256.CrossRefGoogle Scholar
  195. Senni M, Santilli G, Parrella P, De Maria R, Alari G, Berzuini C, et al. A novel prognostic index to determine the impact of cardiac conditions and co-morbidities on one-year outcome in patients with heart failure. Am J Cardiol. 2006;98(8):1076–82.  https://doi.org/10.1016/j.amjcard.2006.05.031.PubMedCrossRefGoogle Scholar
  196. Shen L, Jhund PS, Petrie MC, Claggett BL, Barlera S, Cleland JGF, et al. Declining risk of sudden death in heart failure. N Engl J Med. 2017;377(1):41–51.  https://doi.org/10.1056/NEJMoa1609758.PubMedCrossRefGoogle Scholar
  197. Sidebottom AC, Jorgenson A, Richards H, Kirven J, Sillah A. Inpatient palliative care for patients with acute heart failure: outcomes from a randomized trial. J Palliat Med. 2015;18:134–42.  https://doi.org/10.1089/jpm.2014.0192.PubMedCrossRefGoogle Scholar
  198. Siouta N, van Beek K, Preston N, Hasselaar J, Hughes S, Payne S, et al. Towards integration of palliative care in patients with chronic heart failure and chronic obstructive pulmonary disease: a systematic literature review of European guidelines and pathways. BMC Palliat Care. 2016;15:18.  https://doi.org/10.1186/s12904-016-0089-4.PubMedPubMedCentralCrossRefGoogle Scholar
  199. Small N, Gardiner C, Barnes S, Gott M, Payne S, Seamark D, et al. Using a prediction of death in the next 12 months as a prompt for referral to palliative care acts to the detriment of patients with heart failure and chronic obstructive pulmonary disease. Palliat Med. 2010;24(7):740–1.  https://doi.org/10.1177/0269216310375861.PubMedCrossRefGoogle Scholar
  200. Sokoreli I, de Vries JJ, Pauws SC, Steyerberg EW. Depression and anxiety as predictors of mortality among heart failure patients: systematic review and meta-analysis. Heart Fail Rev. 2016;21(1):49–63.  https://doi.org/10.1007/s10741-015-9517-4.PubMedCrossRefGoogle Scholar
  201. Solano JP, Gomez B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manag. 2006;31:58–69.  https://doi.org/10.1016/j.jpainsymman.2005.06.007.CrossRefGoogle Scholar
  202. Spiess JL. Hospice in heart failure: why, when, and what then? Heart Fail Rev. 2017;22(5):593–604.  https://doi.org/10.1007/s10741-017-9595-6.PubMedCrossRefGoogle Scholar
  203. Steiner JM, Cooper S, Kirkpatrick JN. Palliative care in end-stage valvular heart disease. Heart. 2017;103(16): 1233–7.  https://doi.org/10.1136/heartjnl-2016-310538.PubMedPubMedCentralCrossRefGoogle Scholar
  204. Stewart D, McPherson ML. Symptom management challenges in heart failure: pharmacotherapy considerations. Heart Fail Rev. 2017;22(5):525–34.  https://doi.org/10.1007/s10741-017-9632-5.PubMedCrossRefGoogle Scholar
  205. Stewart GC, Weintraub JR, Patibhu PP, Semigran MJ, Camuso JM, Brooks K, et al. Patient expectations from implantable defibrillators to prevent death in heart failure. J Cardiac Fail. 2010;16:106–13.  https://doi.org/10.1016/j.cardfail.2009.09.003.CrossRefGoogle Scholar
  206. Strachan PH, Ross H, Rocker GM, Dodek PM, Heyland DK, Canadian Researchers at the End of Life Network (CARENET). Mind the gap: opportunities for improving end-of-life care for patients with advanced heart failure. Can J Cardiol. 2009;25:635–40.PubMedPubMedCentralCrossRefGoogle Scholar
  207. Strachan PH, de Laat S, Carroll SL, Schwartz L, Vaandering K, Toor GK, et al. Readability and content of patient education material related to implantable cardioverter defibrillators. J Cardiovasc Nurs. 2012;27(6):495–504.  https://doi.org/10.1097/JCN.0b013e31822ad3dd.PubMedPubMedCentralCrossRefGoogle Scholar
  208. Stulak JM, Davis ME, Haglund N, Dunlay S, Cowger J, Shah P, et al. Adverse events in contemporary continuous-flow left ventricular assist devices: a multi-institutional comparison shows significant differences. J Thorac Cardiovasc Surg. 2016;151(1):177–89.  https://doi.org/10.1016/j.jtcvs.2015.09.100.PubMedCrossRefGoogle Scholar
  209. Swetz KM, Freeman MR, AbouEzzeddine OF, Carter KA, Boilson BA, Ottenberg AL, et al. Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy. Mayo Clin Proc. 2011;86(6): 493–500.  https://doi.org/10.4065/mcp.2010.0747.PubMedPubMedCentralCrossRefGoogle Scholar
  210. Taylor GJ, Lee DM, Baicu CF, Zile MR. Palliative care for advanced heart failure in a Department of Veterans Affairs regional hospice program: patient selection, a treatment protocol, and clinical course. J Palliat Med. 2017;20(10):1068–73.  https://doi.org/10.1089/jpm.2017.0035.PubMedCrossRefGoogle Scholar
  211. Testa G, Cacciatore F, Galizia G, Della-Morte D, Mazzella F, Russo S, et al. Charlson comorbidity index does not predict long-term mortality in elderly subjects with chronic heart failure. Age Ageing. 2009;38(6):734–40.  https://doi.org/10.1093/ageing/afp165.PubMedCrossRefGoogle Scholar
  212. Tevendale E, Baxter J. Heart failure comorbidities at the end of life. Curr Opin Support Palliat Care. 2011;5(4):322–6.  https://doi.org/10.1097/SPC.0b013e32834d2ee4.PubMedCrossRefGoogle Scholar
  213. The Criteria Committee of the New York Heart Association. Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. 9th ed. Boston: Little, Brown & Co; 1994. p. 253–6.Google Scholar
  214. Thoonsen B, Engels Y, van Rijswijk E, Verhagen S, van Weel C, Groot M, et al. Early identification of palliative care patients in general practice: development of RADboud indicators for PAlliative care needs (RADPAC). Br J Gen Pract. 2012;62:625–3.  https://doi.org/10.3399/bjgp12X654597.CrossRefGoogle Scholar
  215. Timmons MJ, MacIver J, Alba AC, Tibbles A, Greenwood S, Ross HJ. Using heart failure instruments to determine when to refer heart failure patients to palliative care. J Palliat Care. 2013;29:217–24.PubMedGoogle Scholar
  216. Treece J, Chemchirian H, Hamilton N, Jbara M, Gangadharan V, Paul T, et al. A review of prognostic tools in heart failure. Am J Hosp Palliat Care. 2017.  https://doi.org/10.1177/1049909117709468.
  217. Udelson JE, Stevenson LW. The future of heart failure diagnosis, therapy, and management. Circulation. 2016;133(25):2671–86.  https://doi.org/10.1161/CIRCULATIONAHA.116.023518.PubMedCrossRefGoogle Scholar
  218. University of Colorado. (2016) Patient Decision Aids – Implantable Cardioverter-Defibrillator (ICD). URL: http://www.patientdecisionaid.org Accessed 5 Nov 2017.
  219. van Deursen VM, Urso R, Laroche C, Damman K, Dahlström U, Tavazzi L, et al. Co-morbidities in patients with heart failure: an analysis of the European heart failure pilot survey. Eur J Heart Fail. 2014;16(1):103–11.  https://doi.org/10.1002/ejhf.30.PubMedCrossRefGoogle Scholar
  220. Waller A, Girgis A, Davidson PM, Newton PJ, Lecathelinais C, Macdonald PS, et al. Facilitating needs-based support and palliative care for people with chronic heart failure: preliminary evidence for the acceptability, inter-rater reliability, and validity of a needs assessment tool. J Pain Symptom Manag. 2013;45:912–25.  https://doi.org/10.1016/j.jpainsymman.2012.05.009.CrossRefGoogle Scholar
  221. White N, Kupeli N, Vickerstaff V, Stone P. How accurate is the ‘Surprise Question’ at identifying patients at the end of life? A systematic review and meta-analysis. BMC Med. 2017;15(1):139.  https://doi.org/10.1186/s12916-017-0907-4.PubMedPubMedCentralCrossRefGoogle Scholar
  222. Wilhelm MJ. Long-term outcome following heart transplantation: current perspective. J Thorac Dis. 2015;7(3):549–51.  https://doi.org/10.3978/j.issn.2072-1439.2015.01.46.PubMedPubMedCentralGoogle Scholar
  223. Wilson A, McMillan S. Symptoms experienced by heart failure patients in hospice care. J Hosp Palliat Nurs. 2013;15:13–21.  https://doi.org/10.1097/NJH.0b013e31827ba343.PubMedPubMedCentralCrossRefGoogle Scholar
  224. Wingate S, Bain KT, Goodlin SJ. Availability of data when heart failure patients are admitted to hospice. Congest Heart Fail. 2011;7(6):303–8.  https://doi.org/10.1111/j.1751-7133.2011.00229.x.CrossRefGoogle Scholar
  225. Wong FK, Ng AY, Lee PH, Lam PT, Ng JS, Ng NH, et al. Effects of a transitional palliative care model on patients with end-stage heart failure: a randomised controlled trial. Heart. 2016;102(14): 1100–8.  https://doi.org/10.1136/heartjnl-2015-308638.PubMedPubMedCentralCrossRefGoogle Scholar
  226. Wordingham SE, Kasten RM, Swetz KM. Total artificial heart #296. J Palliat Med. 2015;18(11): 985–6.  https://doi.org/10.1089/jpm.2015.0243.PubMedCrossRefGoogle Scholar
  227. Wordingham SE, McIlvennan CK, Fendler TJ, Behnken AL, Dunlay SM, Kirkpatrick JN, et al. Palliative care clinicians caring for patients before and after continuous flow-left ventricular assist device. J Pain Symptom Manag. 2017;54(4):601–8.  https://doi.org/10.1016/j.jpainsymman.2017.07.007.CrossRefGoogle Scholar
  228. Wright GA, Klein GJ, Gula LJ. Ethical and legal perspective of implantable cardioverter defibrillator deactivation or implantable cardioverter defibrillator generator replacement in the elderly. Curr Opin Cardiol. 2013;28:43–9.  https://doi.org/10.1097/HCO.0b013e32835b0b3b.PubMedCrossRefGoogle Scholar
  229. Xie K, Gelfman L, Horton JR, Goldstein NE. State of research on palliative care in heart failure as evidenced by published literature, conference proceedings, and NIH funding. J Card Fail. 2017;23(2):197–200.  https://doi.org/10.1016/j.cardfail.2016.10.013.PubMedCrossRefGoogle Scholar
  230. Xu J, Nolan MT, Heinze K, Yenokyan G, Hughes MT, Johnson J. Symptom frequency, severity, and quality of life among persons with three disease trajectories: cancer, ALS, and CHF. Appl Nurs Res. 2015;28(4):311–5.  https://doi.org/10.1016/j.apnr.2015.03.005.PubMedPubMedCentralCrossRefGoogle Scholar
  231. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, et al. 2013 ACCF/AHA guideline for the management of heart failure a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol. 2013;62(16):e147–239.  https://doi.org/10.1016/j.jacc.2013.05.019.PubMedCrossRefGoogle Scholar
  232. Yim CK, Barrón Y, Moore S, Murtaugh C, Lala A, Aldridge M, et al. Hospice enrolment in patients with advanced heart failure decreases acute medical service utilization. Circ Heart Fail. 2017;10(3).  https://doi.org/10.1161/CIRCHEARTFAILURE.116.003335.
  233. Yu DS, Li PW, Chong SO. Symptom cluster among patients with advanced heart failure: a review of its manifestations and impacts on health outcomes. Curr Opin Support Palliat Care. 2017.  https://doi.org/10.1097/SPC.0000000000000316.
  234. Zacharias H, Raw J, Nunn A, Parsons S, Johnson M. Is there a role for subcutaneous furosemide in the community and hospice management of end-stage heart failure? Palliat Med. 2011;25:658–63.  https://doi.org/10.1177/0269216311399490.PubMedCrossRefGoogle Scholar
  235. Zambroski C, Moser D, Bhat G, Ziegler C. Impact of symptom prevalence and symptom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs. 2005;4:198–206.  https://doi.org/10.1016/j.ejcnurse.2005.03.010.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Cicely Saunders InstituteKing’s CollegeLondonUK
  2. 2.National Heart and Lung InstituteImperial CollegeLondonUK

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