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Multiple miRNA Regulation of Lipoprotein Lipase

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Handbook of Nutrition, Diet, and Epigenetics

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Abstract

Lipoprotein lipase (LPL) is the key enzyme involved in the intravascular lipolysis of triglyceride (TG)-rich lipoproteins. The regulation of LPL expression and activity is complexed, tightly regulated by hormonal, nutritional, and genetic mechanisms, which remain partially unknown. LPL is highly regulated at a posttranscriptional level that could involve miRNA. miR-27 and miR-29 families are the most studied miRNAs responsible for a decreased LPL expression, mainly in adipose tissue but also in hepatocytes. These miRNAs and several others, miR-467 and miR-590, have been shown to directly target LPL in macrophages and prevent atherosclerosis in animal models. Moreover, a LPL haplotype associated with lower TG was shown to disrupt several miRNA-binding sites. LPL activity can also indirectly be regulated by miRNA which regulates the expression of its cofactors such as APOA5 and ANGPTL3/4.

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Abbreviations

Angptl:

Angiopoietin-like protein

Apo:

Apolipoprotein

FA:

Fatty acids

GPIHBP1:

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1

HTG:

Hypertriglyceridemia

LPL:

Lipoprotein lipase

miRNA:

MicroRNA

SNP:

Single-nucleotide polymorphism

TG:

Triglycerides

TGRL:

Triglyceride-rich lipoproteins

UTR:

Untranslated region

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Authors and Affiliations

  1. Claude Bernard University, Lyon, 1 INSERM UMR1060, France

    Sybil Charriere & Philippe Moulin

  2. Department of endocrinology, diabetology, metabolic diseases and nutrition, Cardiovascular Hospital Louis Pradel, 28 avenue Doyen Lépine, 69677, Bron Cedex, France

    Sybil Charriere & Philippe Moulin

Authors
  1. Sybil Charriere
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  2. Philippe Moulin
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Correspondence to Sybil Charriere .

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Editors and Affiliations

  1. c/o Editorial Board 978-0-387-78665 , Heidelberg, Baden-Württemberg, Germany

    Vinood Patel

  2. Kings College , London, United Kingdom

    Victor Preedy

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Charriere, S., Moulin, P. (2017). Multiple miRNA Regulation of Lipoprotein Lipase. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_98-1

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  • DOI: https://doi.org/10.1007/978-3-319-31143-2_98-1

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  • Print ISBN: 978-3-319-31143-2

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