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Association Between MicroRNA Expression and Vitamin C in Ovarian Cells

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Handbook of Nutrition, Diet, and Epigenetics

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Abstract

Vitamin C (l-ascorbic acid) is an essential, water-soluble micronutrient that exists predominantly as the ascorbate anion under physiological pH conditions and has been implicated in several processes of reproduction of reproductive organ cells. Several studies described the regulatory roles of vitamin C in various cellular developmental processes, via microRNA mechanism, using in vivo and in vitro animal models. To date, some specific microRNAs have been regarded as candidates that have regulatory roles in vitamin C metabolism. Many questions should be further investigated, such as the following: whether and how vitamin C directly regulates epigenetic modifiers, whether vitamin C regulates gene and miRNA promoters through specific signaling pathways, and whether vitamin C-induced DNA demethylation occurs.

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Abbreviations

μM:

Micro molarity

G-cell:

Granulosa cell

GLUT:

Glucose transporters

Gulo:

l-gulono-γ-lactone oxidase

HDL3:

High-density lipoprotein 3

IGF-1:

Insulin-like growth factor 1

IOM:

Institute of Medicine

IVM:

In vitro maturation

mg:

Milligram

MII:

Meiosis II

miRNAs:

MicroRNAs

ODS:

Osteogenic disorder Shionogi

RDA:

Recommended dietary allowances

SVCT:

Sodium-dependent vitamin C transporters

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Korea University Medical College, Korea University Guro Hospital, 148, Gurodong-ro, Guro-gu, 152-703, Seoul, South Korea

    Yong Jin Kim

  2. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital, 28 Yonkeun-dong, Chongno-gu, 110-744, Seoul, South Korea

    Yoon Young Kim & Seung-Yup Ku

Authors
  1. Yong Jin Kim
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  2. Yoon Young Kim
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  3. Seung-Yup Ku
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Correspondence to Seung-Yup Ku .

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Editors and Affiliations

  1. c/o Editorial Board 978-0-387-78665 , Heidelberg, Baden-Württemberg, Germany

    Vinood Patel

  2. Kings College , London, United Kingdom

    Victor Preedy

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Kim, Y.J., Kim, Y.Y., Ku, SY. (2017). Association Between MicroRNA Expression and Vitamin C in Ovarian Cells. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_80-1

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  • DOI: https://doi.org/10.1007/978-3-319-31143-2_80-1

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  • Print ISBN: 978-3-319-31143-2

  • Online ISBN: 978-3-319-31143-2

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