Abstract
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is an essential orchestrator in energy homeostasis, serving as a substantial node linking nutritional signals to metabolism. Recent studies indicate that peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) promoter DNA methylation is associated with various disorders and plays an important role in metabolic programming. Dietary and nutritional disequilibrium is recognized as a crucial factor which influences the process of epigenetic modification. In this article, we summarize the current knowledge on the impact of both prenatal and postnatal nutritional factors on the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) DNA methylation and their relationship to metabolic disorders, and discuss the unresolved questions that warrant further research.
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Abbreviations
- AGA:
-
Appropriate weight for gestational age
- BMI:
-
Body mass index
- BPA:
-
Bisphenol A
- CG-IUGR:
-
IUGR followed by postnatal catch-up/accelerated growth
- DNMT:
-
DNA methyltransferase
- GDM:
-
Gestational diabetes
- HOMA-IR:
-
Homeostasis model assessment of insulin resistance
- IUGR:
-
Intrauterine growth restriction
- LBW:
-
Low birth weight
- LGA:
-
Large for gestational age
- NAFLD:
-
Nonalcoholic fatty liver disease
- NBW:
-
Normal birth weight
- OGTT:
-
Oral glucose tolerance test
- PGC-1α:
-
Peroxisome proliferator-activated receptor-γ coactivator-1α
- RYGB:
-
Roux-en-Y gastric bypass
- SGA:
-
Small for gestational age
- T1DM:
-
Type 1 diabetes
- T2DM:
-
Type 2 diabetes mellitus
- TNF-α:
-
Tumor necrosis factor-alpha
- TSS:
-
Transcription start site
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Xie, X., Luo, X. (2017). Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1Alpha and DNA Methylation as Epigenetic Control. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_75-1
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DOI: https://doi.org/10.1007/978-3-319-31143-2_75-1
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