Abstract
Low-grade tissue inflammation is a key driver for the development of obesity-induced insulin resistance with a remarkable accumulation of various immune cells in adipose tissues. The proinflammatory activations of immune cells play critical roles in exacerbating the tissue inflammation and insulin resistance in obesity. Here, this review features the regulatory roles of microRNAs on the maturation, recruitment, and activation of both innate and adaptive immune cells in response to obesity, which could reveal the mechanisms underlying the pathogenesis of obesity-related metabolic syndrome.
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Abbreviations
- AML1:
-
Acute myeloid leukemia-1
- ANT:
-
Adenine nucleotide translocase
- ARNT:
-
Aryl hydrocarbon nuclear translocator
- ATMs:
-
Adipose tissue macrophages
- BCR:
-
B cell receptor
- BMI:
-
Body mass index
- C/EBPσ:
-
CCAAT/enhancer binding protein-σ
- CCL2:
-
Chemokine (C-C motif) ligand 2
- CDR3:
-
Complementary determining region 3
- Dusp5:
-
Dual-specificity protein phosphatase 5
- ETS1:
-
V-ets erythroblastosis virus E26 oncogene homolog 1 avian
- Foxp3:
-
Forkhead box P3
- HFD:
-
High-fat diet
- HIF1α:
-
Hypoxia-inducible factor 1α
- IL-4:
-
Interleukin-4
- Irak1:
-
IL-1 receptor-associated kinase 1
- IRF4:
-
Interferon regulatory factor 4
- LPS:
-
Lipopolysaccharide
- LTB4:
-
Leukotriene B4
- M-CSFR:
-
Macrophage colony-stimulating factor receptor
- MAX:
-
MYC-associated factor X
- MHC II:
-
Major histocompatibility complex class II
- miRNAs:
-
MicroRNAs
- NFκB:
-
Nuclear factor κB
- Pknox1:
-
PBX/knotted 1 homeobox 1
- Ptpn11:
-
Protein tyrosine phosphatase type 11
- T2DM:
-
Type 2 diabetes mellitus
- Th1:
-
T helper type 1
- Th2:
-
T helper type 2
- Traf6:
-
TNF receptor-associated factor 6
- Tregs:
-
T regulatory cells
- VATs:
-
Obese visceral adipose tissues
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Zhou, B., Ying, W., Li, C., Vella, A.T. (2017). MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_26-1
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DOI: https://doi.org/10.1007/978-3-319-31143-2_26-1
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