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Handbook of Nutrition, Diet, and Epigenetics pp 1–18Cite as

MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue

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Abstract

Low-grade tissue inflammation is a key driver for the development of obesity-induced insulin resistance with a remarkable accumulation of various immune cells in adipose tissues. The proinflammatory activations of immune cells play critical roles in exacerbating the tissue inflammation and insulin resistance in obesity. Here, this review features the regulatory roles of microRNAs on the maturation, recruitment, and activation of both innate and adaptive immune cells in response to obesity, which could reveal the mechanisms underlying the pathogenesis of obesity-related metabolic syndrome.

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Abbreviations

AML1:

Acute myeloid leukemia-1

ANT:

Adenine nucleotide translocase

ARNT:

Aryl hydrocarbon nuclear translocator

ATMs:

Adipose tissue macrophages

BCR:

B cell receptor

BMI:

Body mass index

C/EBPσ:

CCAAT/enhancer binding protein-σ

CCL2:

Chemokine (C-C motif) ligand 2

CDR3:

Complementary determining region 3

Dusp5:

Dual-specificity protein phosphatase 5

ETS1:

V-ets erythroblastosis virus E26 oncogene homolog 1 avian

Foxp3:

Forkhead box P3

HFD:

High-fat diet

HIF1α:

Hypoxia-inducible factor 1α

IL-4:

Interleukin-4

Irak1:

IL-1 receptor-associated kinase 1

IRF4:

Interferon regulatory factor 4

LPS:

Lipopolysaccharide

LTB4:

Leukotriene B4

M-CSFR:

Macrophage colony-stimulating factor receptor

MAX:

MYC-associated factor X

MHC II:

Major histocompatibility complex class II

miRNAs:

MicroRNAs

NFκB:

Nuclear factor κB

Pknox1:

PBX/knotted 1 homeobox 1

Ptpn11:

Protein tyrosine phosphatase type 11

T2DM:

Type 2 diabetes mellitus

Th1:

T helper type 1

Th2:

T helper type 2

Traf6:

TNF receptor-associated factor 6

Tregs:

T regulatory cells

VATs:

Obese visceral adipose tissues

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, 06030, USA

    Beiyan Zhou, Chuan Li & Anthony T. Vella

  2. Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA

    Wei Ying

Authors
  1. Beiyan Zhou
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  2. Wei Ying
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  3. Chuan Li
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  4. Anthony T. Vella
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Correspondence to Beiyan Zhou .

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Editors and Affiliations

  1. c/o Editorial Board 978-0-387-78665 , Heidelberg, Baden-Württemberg, Germany

    Vinood Patel

  2. Kings College , London, United Kingdom

    Victor Preedy

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Zhou, B., Ying, W., Li, C., Vella, A.T. (2017). MicroRNA-Regulated Immune Cell Function in Obese Adipose Tissue. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_26-1

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  • DOI: https://doi.org/10.1007/978-3-319-31143-2_26-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31143-2

  • Online ISBN: 978-3-319-31143-2

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