Abstract
Diet nutrition has been confirmed to influence health for decades. Proper total nutrition intake is beneficial for organisms’ health from yeast, insects, rodents, to humans. Epigenetic factors are considered to be one of the mediators of the dietary effects, which make the effects remembered from one cell generation to the next by marking on the genome. In this chapter, we will review the accumulative evidences about the association between epigenetic factors (including DNA methylation, histone modifications, and other epigenetic factors), and diet nutrition especially dietary restriction, and its implications for humankind. At the same time, we suggest that insects can be employed as efficient models to investigate the fundamental basis of human diseases especially the involvement of epigenetic mechanisms, because insects owe inexpensive cost, easy accessibility, shorter generations, along with conserved epigenetic mechanisms and signaling pathways with humans.
Abbreviations
- 5mC:
-
5-Methylcytosine
- 6mA:
-
N6-Methyladenine
- 10-HDA:
-
(E)-10-hydroxy-2-decenoic acid
- ChIP-seq:
-
Chromatin immunoprecipitation sequencing
- DMGs:
-
Differentiated methylated genes
- Dnmts:
-
DNA methyltransferases
- DR:
-
Dietary restriction
- EGFR:
-
Epidermal growth factor receptor
- H3K27ac:
-
Histone H3 at lysine 27
- HAD:
-
10-hydroxy-2-decenoic acid
- HDAC:
-
Histone deacetylase
- HDACi:
-
Histone deacetylase inhibitor
- LC-MS/MS:
-
Liquid chromatography coupled with tandem mass spectrometry
- lnc-RNAs:
-
Long noncoding RNAs
- LPHC:
-
Low-protein, high-carbohydrate diet
- OCM:
-
One-carbon metabolism
- RJ:
-
Royal jelly
- SAM:
-
S-adenosylmethionine
- Sir2 :
-
Sirtuin-2
- TEs:
-
Transposable elements
- WJ:
-
Worker jelly
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Lian, T., Gaur, U., Yang, M. (2017). Epigenetics, Dietary Restriction, and Insects: Implications for Humankind. In: Patel, V., Preedy, V. (eds) Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. https://doi.org/10.1007/978-3-319-31143-2_25-1
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DOI: https://doi.org/10.1007/978-3-319-31143-2_25-1
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