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Patent Ductus Arteriosus

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Neonatology

Abstract

Patent ductus arteriosus (PDA) continues to be a frequent complication of extremely premature birth, despite the more generalized use of antenatal steroids, postnatal surfactant administration, and the improvement of noninvasive ventilatory strategies. Its incidence is inversely related to gestational age, such that it affects almost 60% of infants less than 28 weeks’ gestation. Spontaneous closure of the ductus occurs in 30% of infants with very low birth weight (<1500 g). When the PDA is hampering the neonate’s well-being, judicious evaluation and tailoring of the best therapeutic strategy should be performed. Ibuprofen actually seems to be the preferred drug for pharmacological treatment because of its favorable risk/benefit ratio; the therapeutic response of the most immature infants however is limited. Surgical ligation of the duct should be considered as a backup treatment due to the risks of serious complications during and after the procedure.

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Author information

Authors and Affiliations

  1. Neonatology Service, Erasmus Hospital Université Libre de Bruxelles, Brussels, Belgium

    Bart Van Overmeire

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  1. Bart Van Overmeire
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Editors and Affiliations

  1. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore

  2. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women’s Hospital Neonatal Unit, Liverpool, UK

    Michael Weindling

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Van Overmeire, B. (2018). Patent Ductus Arteriosus. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-29489-6_219

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  • DOI: https://doi.org/10.1007/978-3-319-29489-6_219

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29487-2

  • Online ISBN: 978-3-319-29489-6

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