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Meconium Aspiration Syndrome

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Neonatology

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Abstract

Meconium aspiration syndrome is a disease characterized by a respiratory insufficiency of variable severity, where lung injury probably starts prenatally. The role of meconium in the pathogenesis of the disease is still partly unknown, while increasing evidence suggests that chronic in utero insults may be responsible for starting lung damage as well as triggering fetal distress and meconium passage into the amniotic fluid. Survival rate has greatly improved over the last three decades with newer and more efficient modalities of treatment. On the other hand, concern exists about the long-term neurodevelopmental and pulmonary outcome of survivors.

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Abbreviations

ECMO:

Extracorporeal membrane oxygenation

HFOV:

High-frequency oscillatory ventilation

iNO:

Inhaled nitric oxide

MAS:

Meconium aspiration syndrome

MSAF:

Meconium-stained amniotic fluid

References

  • ACOG Committee Obstetric Practice (2006) ACOG Committee Opinion Number 346, October 2006: amnioinfusion does not prevent meconium aspiration syndrome. Obstet Gynecol 108:1053

    Article  Google Scholar 

  • ACOG Committee on Obstetric Practice (2007) ACOG Committee Opinion No. 379: Management of delivery of a newborn with meconium-stained amniotic fluid. Obstet Gynecol 110(3):739

    Article  Google Scholar 

  • Cayabyab RG, Kwong K, Jones C et al (2007) Lung inflammation and pulmonary function in infants with meconium aspiration syndrome. Pediatr Pulmonol 42:898–905

    Article  Google Scholar 

  • Chettri S, Adhisivam B, Bhat BV (2015) Endotracheal suction for nonvigorous neonates born through meconium stained amniotic fluid: a randomized controlled trial. J Pediatr 166(5):1208–1213.e1

    Article  Google Scholar 

  • Cleary GM, Wiswell TE (1998) Meconium-stained amniotic fluid and the meconium aspiration syndrome: an update. Pediatr Clin N Am 45:511–529

    Article  CAS  Google Scholar 

  • Dargaville PA, Copnell B, Tingay DG et al (2008) Refining the method of therapeutic lung lavage in meconium aspiration syndrome. Neonatology 94:160–163

    Article  Google Scholar 

  • El Shahed AI, Dargaville P, Ohlsson A, Soll RF (2014) Surfactant for meconium aspiration syndrome in term and late preterm infants. Cochrane Database Syst Rev 12, CD002054

    Google Scholar 

  • Finer NN, Barrington KJ (2006) Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev 4, CD000399

    Google Scholar 

  • Garg N, Choudhary M, Sharma D, Dabi D, Choudhary JS, Choudhary SK (2016) The role of early inhaled budesonide therapy in meconium aspiration in term newborns: a randomized control study. J Matern Fetal Neonatal Med 29(1):36–40

    Article  CAS  Google Scholar 

  • Geiger R, Kleinsasser A, Meier S et al (2008) Intravenous tezosentan improves gas exchange and hemodynamics in acute lung injury secondary to meconium aspiration. Intensive Care Med 34(2):368–376

    Article  CAS  Google Scholar 

  • Ghidini A, Spong CY (2001) Severe meconium aspiration syndrome is not caused by aspiration of meconium. Am J Obstet Gynecol 185:931–938

    Article  CAS  Google Scholar 

  • Hahn S, Choi HJ, Soll R, Dargaville PA (2013) Lung lavage for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev 4, CD003486

    Google Scholar 

  • Herting E, Rauprich P, Stichtenoth G et al (2001) Resistance of different surfactant preparations to inactivation by meconium. Pediatr Res 50:44–49

    Article  CAS  Google Scholar 

  • Kinsella JP, Truog WE, Walsh WF et al (1997) Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 131:55–62

    Article  CAS  Google Scholar 

  • Kugelman A, Gangitano E, Taschuk R et al (2005) Extracorporeal membrane oxygenation in infants with meconium aspiration syndrome: a decade of experience with venovenous ECMO. J Pediatr Surg 40:1082–1089

    Article  Google Scholar 

  • Petrikovsky B (2004) In utero meconium suctioning may prevent meconium aspiration. Fetal Diagn Ther 19:533e5

    Article  Google Scholar 

  • Rais-Bahrami KRO, Seale WR, Short BL (1997) Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant. Crit Care Med 25(10):1744–1747

    Article  CAS  Google Scholar 

  • Singh BS, Clark RH, Powers RJ, Spitzer AR (2009) Meconium aspiration syndrome remains a significant problem in the NICU: outcomes and treatment patterns in term neonates admitted for intensive care during a ten-year period. J Perinatol 29:1–7

    Article  CAS  Google Scholar 

  • Tessler R, Pan J, Holmer Fiori H, Belik J (2008) Human meconium has a pulmonary vascular and airway smooth muscle relaxant effect. Pediatr Res 64(1):24–28

    Article  Google Scholar 

  • Thureen PJ, Hall DM, Hoffenberg A, Tyson RW (1997) Fatal meconium aspiration in spite of appropriate perinatal airway management: pulmonary and placental evidence of prenatal disease. Am J Obstet Gynecol 176:967–975

    Article  CAS  Google Scholar 

  • Tripathi S, Saili A (2007) The effect of steroids on the clinical course and outcome of neonates with meconium aspiration syndrome. J Trop Pediatr 53:8–12

    Article  Google Scholar 

  • Walsh MC, Fanaroff JM (2007) Meconium stained fluid: approach to the mother and the baby. Clin Perinatol 34:653–665

    Article  Google Scholar 

  • Ward M, Sinn J (2003) Steroid therapy for meconium aspiration syndrome in newborn infants. Cochrane Database Syst Rev;(4) CD003485

    Google Scholar 

  • Wiswell TE, Gannon CM, Jacob J et al (2000) Delivery room management of apparently vigorous meconium-stained neonate: results of the multicenter, international trial. Pediatrics 105:1–7

    Article  CAS  Google Scholar 

  • Wyckoff MH, Aziz K, Escobedo MB, Kapadia VS et al (2015) Part 13: neonatal resuscitation: 2015 American Heart Association Guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Pediatrics 136(Suppl 2):S196–S218

    Article  Google Scholar 

  • Xu H, Hofmeyr J, Roy C, Fraser WD (2007) Intrapartum amnioinfusion for meconium-stained fluid: a systematic review of randomised controlled trials. BJOG 114:383–390

    Article  CAS  Google Scholar 

  • Zagariya A, Bhat R, Navale S et al (2006) Inhibition of meconium-induced cytokine expression and cell apoptosis by pre-treatment with captopril. Pediatrics 117(5):1722–1727

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Neonatal Intensive Care Unit, Careggi University Hospital, Florence, Italy

    Simone Pratesi & Carlo Dani

  2. Università degli Studi di Firenze, Florence, Italy

    Carlo Dani

Authors
  1. Simone Pratesi
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  2. Carlo Dani
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Corresponding author

Correspondence to Carlo Dani .

Editor information

Editors and Affiliations

  1. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Giuseppe Buonocore

  2. Department of Pediatrics Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women’s Hospital Neonatal Unit, Liverpool, UK

    Michael Weindling

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Pratesi, S., Dani, C. (2018). Meconium Aspiration Syndrome. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-29489-6_199

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  • DOI: https://doi.org/10.1007/978-3-319-29489-6_199

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-29487-2

  • Online ISBN: 978-3-319-29489-6

  • eBook Packages: MedicineReference Module Medicine

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