Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Hairy Leukoplakia

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_725-1



Oral hairy leukoplakia (OHL) is one of the many new disease entities brought to light by the epidemic of HIV infection. It is an Epstein-Barr virus (EBV)-associated lesion presenting as a unilateral or bilateral, white mucosal plaque, usually located on the lateral border(s) of the tongue, that does not rub off and is histopathologically characterized pattern of hyperkeratosis and hairlike epithelial hyperplasia (Fig. 1). OHL is not exclusive to patients with HIV infection but can also be observed in other immune-compressed patients.
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References and Further Reading

  1. Greenspan, D., & Greenspan, J. S. (1992). Significance of oral hairy leukoplakia. Oral Surgery, Oral Medicine, and Oral Pathology, 73, 151–154.CrossRefPubMedGoogle Scholar
  2. Greenspan, D., & Greenspan, J. S. (1996). HIV-related oral disease. Lancet, 348, 729–733.CrossRefPubMedGoogle Scholar
  3. Greenspan, J. S., Greenspan, D., & Webster-Cyriaque, J. (2016). Hairy leukoplakia; lessons learned: 30-plus years. Oral Diseases, 22, 120–127.CrossRefPubMedGoogle Scholar
  4. Piperi, E., Omlie, J., Koutlas, I. G., & Pambuccian, S. (2010). Oral hairy leukoplakia in HIV-negative patients: Report of 10 cases. International Journal of Surgical Pathology, 18, 177–183.CrossRefPubMedGoogle Scholar
  5. Triantos, D., Porter, S. R., Scully, C., & Teo, C. G. (1997). Oral hairy leukoplakia: Clinicopathologic features, pathogenesis, diagnosis and clinical significance. Clinical Infectious Diseases, 25, 1392–1396.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands