Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Giant Cell Fibroma

  • Jacqueline E. van der Wal
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_714-1


The giant cell fibroma is a benign, fibrous tumor with multiple large fibroblasts, not associated with trauma or chronic irritation. The etiology of the lesion still remains unknown. It presents as a sessile or pedunculated nodule, usually less than 1 cm in diameter with a flat or papillary surface colored similar to the oral mucosa.

Clinical Features


Two to five percent of all oral fibrous proliferations.


Peak incidence in the second decade and 60% in the first three decades.


Slightly more females (female-to-male ratio 1.3:1).


Predilection for the gingiva, mandible/maxilla nearly 2:1, besides, the tongue, palate, buccal mucosa, and lip.


Local surgical excision.


Recurrence is rare.


A mass of loosely arranged vascular fibrous tissue covered by a non-ulcerated mucosa. Within the superficial tissue numerous large, stellate fibroblasts are present in the absence of inflammation. These fibroblasts may contain several nuclei. The...
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References and Further Reading

  1. de Andrade Santos, P. P., Nonaka, C. F. W., Pinto, L. P., & de Souza, L. B. (2011). Immunohistochemical expression of mast cell tryptase in giant cell fibroma and inflammatory fibrous hyperplasia of the oral mucosa. Archives of Oral Biology, 56(3), 231–237.CrossRefGoogle Scholar
  2. de Oliveira, H. C., et al. (2016). MMP-1 and MMP-8 expression in giant cell fibroma and inflammatory fibrous hyperplasia. Pathology Research and Practice, 212, 1108–1112.CrossRefGoogle Scholar
  3. Houston, G. D. (1982). The giant cell fibroma. Oral Surgery, Oral Medicine, and Oral Pathology, 53, 582–587.CrossRefPubMedGoogle Scholar
  4. Magnusson, B. C., & Rasmusson, L. G. (1995). The giant cell fibroma. A review of 103 cases with immunohistochemical findings. Acta Odontologica Scandinavica, 53, 293–296.CrossRefPubMedGoogle Scholar
  5. Souza, L. B., Andrade, E. S. S., Miguel, M. C. C., Freitas, R. A., & Pinto, L. P. (2004). Origin of stellate giant cells in oral fibrous lesions determined by immunohistochemical expression of vimentin, HHF-35, CD68 and factor XIIIa. Pathology, 36, 316–320.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyThe Netherlands Cancer Institute, Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands